Fluoromethyl phenyl sulfone
- Product Name
- Fluoromethyl phenyl sulfone
- CAS No.
- 20808-12-2
- Chemical Name
- Fluoromethyl phenyl sulfone
- Synonyms
- FLUOROMETHYLSULFONYLBENZENE;FLUOROMETHYL PHENYL SULFONE;FluoromethylPhenylSulfone>Phenyl Fluoromethyl Sulfone;Fluoromethanesulfonyl-benzene;Benzene, [(fluoromethyl)sulfonyl]-
- CBNumber
- CB7230066
- Molecular Formula
- C7H7FO2S
- Formula Weight
- 174.19
- MOL File
- 20808-12-2.mol
Fluoromethyl phenyl sulfone Property
- Melting point:
- 53 °C
- Boiling point:
- 151 °C(Press: 0.3 Torr)
- Density
- 1.274±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- soluble in Methanol
- form
- powder to crystal
- color
- White to Almost white
Safety
- Safety Statements
- 24/25
- HS Code
- 29309090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- F0341
- Product name
- Fluoromethyl Phenyl Sulfone
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $217
- Updated
- 2024/03/01
- Product number
- F0341
- Product name
- Fluoromethyl Phenyl Sulfone
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $730
- Updated
- 2024/03/01
- Product number
- F597978
- Product name
- Fluoromethyl Phenyl Sulfone
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- JK267664
- Product name
- Fluoromethyl Phenyl Sulfone
- Purity
- 98%
- Packaging
- 250mg
- Price
- $51
- Updated
- 2021/12/16
- Product number
- 42384
- Product name
- Fluoromethylphenylsulfone,98%(GC)
- Purity
- 98%(GC)
- Packaging
- 5G
- Price
- $713.44
- Updated
- 2021/12/16
Fluoromethyl phenyl sulfone Chemical Properties,Usage,Production
Description
Fluoromethyl phenyl sulfone is a useful nucleophilic monofluoromethylation reagent for the synthesis of fluoromethyl alcohols and amines. In the nucleophilic reaction step, strong bases such as LiHMDS and n-BuLi are used to generate the nucleophilic (phenylsulfonyl)fluoromethyl anion. In the desulfonylation step, sodium/mercury amalgam and magnesium are the commonly used reductive reagents. Besides, the addition reaction between fluoromethyl phenyl sulfone and carbonyls can be used to prepare monofluoroaklenes via acylation–elimination.
Uses
Fluoromethyl phenyl sulfone can be used to prepare monofluoroaklenes and chiral α-Monofluoromethyl Amines. Highly stereoselective nucleophilic monofluoromethylation of (R)-(tert-butanesulfinyl)imines with fluoromethyl phenyl sulfone was achieved to afford α-monofluoromethylamines with a nonchelation-controlled stereoselectivity mode. By using the same chemistry, (R)-(tert-butanesulfinyl)imines bearing a terminal tosylate (OTs) group can be converted to α-monofluoromethylated cyclic secondary amines with high stereoselectivity.
Reactions
(1) Monofluoromethylation of aldehydes and ketones.
(2) Monofluoromethylation of aldimines and ketimines.
(3) Monofluoromethylenation of aldehydes and ketones.
(4) (Phenylsulfonyl)fluoromethylation of esters.
References
[1] YA LI. Stereoselective Nucleophilic Monofluoromethylation of N-(tert-Butanesulfinyl)imines with Fluoromethyl Phenyl Sulfone[J]. Organic Letters, 2006. DOI:10.1021/ol060322t.
[2] M. INBASEKARAN. ChemInform Abstract: A NOVEL AND EFFICIENT SYNTHESIS OF FLUOROMETHYL PHENYL SULFONE AND ITS USE AS A FLUOROMETHYL WITTIG EQUIVALENT[J]. ChemInform, 1985. DOI:10.1002/chin.198536160.
[3] GOUVERNEUR V, LOZANO ó. Preparation of Chiral α-Monofluoromethyl Amines Using Fluoromethyl Phenyl Sulfone[C]. 1900. DOI:10.1055/sos-SD-203-00578.
Fluoromethyl phenyl sulfone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Fluoromethyl phenyl sulfone manufacturers
- Product
- Fluoromethyl phenyl sulfone 20808-12-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-09