Fluoromethyl phenyl sulfone

Product Name: Fluoromethyl phenyl sulfone
CAS No.: 20808-12-2
Chemical Name: Fluoromethyl phenyl sulfone
Synonyms: FLUOROMETHYLSULFONYLBENZENE;FLUOROMETHYL PHENYL SULFONE;FluoromethylPhenylSulfone>Phenyl Fluoromethyl Sulfone;Fluoromethanesulfonyl-benzene;Benzene, [(fluoromethyl)sulfonyl]-
CBNumber: CB7230066
Molecular Formula: C7H7FO2S
Formula Weight: 174.19
MOL File: 20808-12-2.mol

More

Less

Fluoromethyl phenyl sulfone Property

Melting point:: 53 °C
Boiling point:: 151 °C(Press: 0.3 Torr)
Density: 1.274±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: soluble in Methanol
form: powder to crystal
color: White to Almost white

More

Less

Safety

Safety Statements: 24/25
HS Code: 29309090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

More

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: F0341
Product name: Fluoromethyl Phenyl Sulfone
Purity: >98.0%(GC)
Packaging: 1g
Price: $217
Updated: 2024/03/01

TCI Chemical

Product number: F0341
Product name: Fluoromethyl Phenyl Sulfone
Purity: >98.0%(GC)
Packaging: 5g
Price: $730
Updated: 2024/03/01

TRC

Product number: F597978
Product name: Fluoromethyl Phenyl Sulfone
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK267664
Product name: Fluoromethyl Phenyl Sulfone
Purity: 98%
Packaging: 250mg
Price: $51
Updated: 2021/12/16

Apolloscientific

Product number: PC905535
Product name: Fluoromethyl Phenyl Sulfone
Purity: 98%
Packaging: 1g
Price: $115
Updated: 2021/12/16

More

Less

Fluoromethyl phenyl sulfone Chemical Properties,Usage,Production

Description

Fluoromethyl phenyl sulfone is a useful nucleophilic monofluoromethylation reagent for the synthesis of fluoromethyl alcohols and amines. In the nucleophilic reaction step, strong bases such as LiHMDS and n-BuLi are used to generate the nucleophilic (phenylsulfonyl)fluoromethyl anion. In the desulfonylation step, sodium/mercury amalgam and magnesium are the commonly used reductive reagents. Besides, the addition reaction between fluoromethyl phenyl sulfone and carbonyls can be used to prepare monofluoroaklenes via acylation–elimination.

Uses

Fluoromethyl phenyl sulfone can be used to prepare monofluoroaklenes and chiral α-Monofluoromethyl Amines. Highly stereoselective nucleophilic monofluoromethylation of (R)-(tert-butanesulfinyl)imines with fluoromethyl phenyl sulfone was achieved to afford α-monofluoromethylamines with a nonchelation-controlled stereoselectivity mode. By using the same chemistry, (R)-(tert-butanesulfinyl)imines bearing a terminal tosylate (OTs) group can be converted to α-monofluoromethylated cyclic secondary amines with high stereoselectivity.

Reactions

(1) Monofluoromethylation of aldehydes and ketones.

(2) Monofluoromethylation of aldimines and ketimines.

(3) Monofluoromethylenation of aldehydes and ketones.

(4) (Phenylsulfonyl)fluoromethylation of esters.

References

[1] YA LI. Stereoselective Nucleophilic Monofluoromethylation of N-(tert-Butanesulfinyl)imines with Fluoromethyl Phenyl Sulfone[J]. Organic Letters, 2006. DOI:10.1021/ol060322t.
[2] M. INBASEKARAN. ChemInform Abstract: A NOVEL AND EFFICIENT SYNTHESIS OF FLUOROMETHYL PHENYL SULFONE AND ITS USE AS A FLUOROMETHYL WITTIG EQUIVALENT[J]. ChemInform, 1985. DOI:10.1002/chin.198536160.
[3] GOUVERNEUR V, LOZANO ó. Preparation of Chiral α-Monofluoromethyl Amines Using Fluoromethyl Phenyl Sulfone[C]. 1900. DOI:10.1055/sos-SD-203-00578.

Fluoromethyl phenyl sulfone Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Fluoromethyl phenyl sulfone Suppliers

Americas 1 China 77 Europe 1 France 1 Germany 2 India 3 Japan 1 United Kingdom 5 United States 10 Global 101

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

United States Biological

Tel: --
Fax: --
Email: chemicals@usbio.net
Country: United States
ProdList: 6214
Advantage: 80

Combi-Blocks Inc.

Tel: --
Fax: --
Email: sales@combi-blocks.com
Country: United States
ProdList: 6618
Advantage: 69

TCI America

Tel: --
Fax: --
Email: sales@tciamerica.com
Country: United States
ProdList: 6909
Advantage: 75

Frontier Scientific, Inc.

Tel: --
Fax: --
Email: sales@frontiersci.com
Country: United States
ProdList: 6222
Advantage: 86

Matrix Scientific

Tel: --
Fax: --
Email: sales@matrixscientific.com
Country: United States
ProdList: 6632
Advantage: 80

Alfa Chemistry

Tel: --
Fax: --
Email: info@Alfa-Chemistry.com
Country: United States
ProdList: 6814
Advantage: 0

Riedel-de Haen AG

Tel: --
Fax: --
Country: United States
ProdList: 6773
Advantage: 87

Oakwood Products, Inc.

Tel: --
Fax: --
Email: sales@oakwoodchemical.com
Country: United States
ProdList: 6193
Advantage: 74

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6718
Advantage: 47

More

Less

View Lastest Price from Fluoromethyl phenyl sulfone manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: Fluoromethyl phenyl sulfone 20808-12-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-09

20808-12-2, Fluoromethyl phenyl sulfoneRelated Search:

PHENYL VALERATE Chlorodimethylphenylsilane Dimethyl sulfoxide Trimethylphenylammonium chloride Dimethyl sulfone Tetradifon Methyltriphenylphosphonium bromide PHENYL RESIN Phenylacetic acid 2-NITRO-4-(TRIFLUOROMETHYLSULFONYL)ANILINE 4-(TRIFLUOROMETHYLSULFONYL)ANILINE 2-CHLORO-5-(TRIFLUOROMETHYLSULFONYL)ANILINE 4-(TRIFLUOROMETHYLSULFONYL)CHLOBENZENE 4-(DIFLUOROMETHYLSULFONYL)NITROBENZENE 4-(DIFLUOROMETHYLSULFONYL)CHLOROBENZENE Phenyl (trifluoromethyl) sulfone 4-CHLOROPHENYL 2-CHLORO-1,1,2-TRIFLUOROETHYL SULFONE 1-CHLORO-2-NITRO-4-TRIFLUOROMETHANESULFONYL-BENZENE

Fluoromethanesulfonyl-benzene

FLUOROMETHYL PHENYL SULFONE

FLUOROMETHYLSULFONYLBENZENE

Phenyl Fluoromethyl Sulfone

FluoromethylPhenylSulfone&gt

Benzene, [(fluoromethyl)sulfonyl]-

20808-12-2

Reagents for Oligosaccharide Synthesis

Fluorinated Building Blocks

Sulfur Compounds (for Synthesis)

Fluorinating Reagents & Building Blocks for Fluorinated Biochemical Compounds

Biochemistry

Fluorinated Building Blocks

Fluorinating Reagents & Building Blocks for Fluorinated Biochemical Compounds

Reagents for Oligosaccharide Synthesis

Sulfur Compounds (for Synthesis)

Synthetic Organic Chemistry