REMODULIN
- Product Name
- REMODULIN
- CAS No.
- 81846-19-7
- Chemical Name
- REMODULIN
- Synonyms
- TREPROSTINIL;Orenitram;2-(((1R,2R,3aS,9aS)-2-hydroxy-1-((S)-3-hydroxyoctyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-5-yl)oxy)acetic acid;UT-15;LRX 15;BW 15AU;U 62840;15AU-81;Uniprost;Ruidulin
- CBNumber
- CB7231250
- Molecular Formula
- C23H34O5
- Formula Weight
- 390.51
- MOL File
- 81846-19-7.mol
REMODULIN Property
- Melting point:
- 121-123°
- Boiling point:
- 587.1±50.0 °C(Predicted)
- Density
- 1.158±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- Chloroform (Slightly, Heated), Methanol (Slightly, Heated)
- form
- Solid
- pka
- 3.19±0.10(Predicted)
- color
- Off-White to Beige
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H311Toxic in contact with skin
H331Toxic if inhaled
H361Suspected of damaging fertility or the unborn child
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313IF exposed or concerned: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 10162
- Product name
- Treprostinil
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $97
- Updated
- 2024/03/01
- Product number
- 10162
- Product name
- Treprostinil
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $433
- Updated
- 2024/03/01
- Product number
- 10162
- Product name
- Treprostinil
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $768
- Updated
- 2024/03/01
- Product number
- 5349
- Product name
- Treprostinil
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $270
- Updated
- 2021/12/16
- Product number
- T719500
- Product name
- Treprostinil
- Packaging
- 10mg
- Price
- $615
- Updated
- 2021/12/16
REMODULIN Chemical Properties,Usage,Production
Uses
Synthetic analog of Prostacyclin (P839060). Antihypertensive. Treprostinil, marketed under the trade name Remodulin is a medication used to treat pulmonary arterial hypertension (PAH).
Definition
ChEBI: Treprostinil is a carboxylic acid and a carbotricyclic compound. It has a role as a platelet aggregation inhibitor, a vasodilator agent, an antihypertensive agent, a cardiovascular drug, a vitamin K antagonist and a human blood serum metabolite.
Pharmacokinetics
Treprostinil is rapidly absorbed from the subcutaneous site of infusion, with an almost 100% bioavailability and a mean half-life of 85 minutes (34 minutes for the IV infusion). The IV solution must be diluted with normal saline or sterile water before starting the infusion. Unlike epoprostenol, treprostinil is stable at room temperature for up to 5 years, with vasodilation action lasting from 4 to 6 hours, compared with the short, 2- to 3-minute action for epoprostenol. Because of its long life in the body, it can be administered under the skin with a microinfusion subcutaneous infusion pump rather than into the bloodstream and, thus, without hospitalization, as contrasted with the central IV infusion of epoprostenol.
Clinical Use
Treprostinil is a synthetic, stable form of prostacyclin for the treatment for advanced pulmonary hypertension with NYHA class III or IV symptoms as well as for late-stage peripheral vascular disease (PVD). Its sodium salt injectable form is administered either as a continuous subcutaneous infusion directly into the skin or, if the subcutaneous infusion is not tolerated, as a continuous IV infusion without an implanted catheter.
Side effects
Side effects include jaw pain, headaches, nausea, diarrhea, flushing, and localized pain at the delivery site under the skin. This pain has been reported as slight to severe irritation. Patients using the drug seem to ex-perience improvement in their condition, including decreased fatigue, decreased shortness of breath, and decreased pulmonary artery pressures, as well as overall improvement in quality of life.
storage
Store at -20°C
REMODULIN Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from REMODULIN manufacturers
- Product
- REMODULIN 81846-19-7
- Price
- US $68.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2023-03-24
- Product
- REMODULIN 81846-19-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-06-11
- Product
- REMODULIN 81846-19-7
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2020-02-18