KIFUNENSINE
- Product Name
- KIFUNENSINE
- CAS No.
- 109944-15-2
- Chemical Name
- KIFUNENSINE
- Synonyms
- FR 900494;Kifunensin;KIFUNENSINE;Kifunensine min. 99%;[5R-(5α,6β,7α,8α,8aα)]-;Kifunensine, (+)- - FR 900494;KIFUNENSINE, KITASATOSPORIA KIFUNENSE;Kifunensine, Kitasatosporia kifunense;Kifunensine, class I alpha-mannosidase inhibitor;Kifunensine, Kitasatosporia kifunense - CAS 109944-15-2 - Calbiochem
- CBNumber
- CB7233173
- Molecular Formula
- C8H12N2O6
- Formula Weight
- 232.19
- MOL File
- 109944-15-2.mol
KIFUNENSINE Property
- Melting point:
- >280°C
- Density
- 1.85±0.1 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- water, double-distilled: soluble50MM
- form
- White solid
- pka
- 9.61±0.70(Predicted)
- color
- White
- biological source
- synthetic (organic)
- Water Solubility
- Soluble to 5 mM in water with sonication
- Stability:
- Desiccate and Store at -20°C
Safety
- WGK Germany
- 3
- HS Code
- 2939800000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- K1140
- Product name
- Kifunensine
- Purity
- mannosidase inhibitor
- Packaging
- 1mg
- Price
- $263
- Updated
- 2024/03/01
- Product number
- 422500
- Product name
- Kifunensine
- Purity
- A potent alkaloid inhibitor of mannosidase I.
- Packaging
- 1mg
- Price
- $390
- Updated
- 2024/03/01
- Product number
- 10009437
- Product name
- Kifunensine
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $65
- Updated
- 2024/03/01
- Product number
- 10009437
- Product name
- Kifunensine
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $179
- Updated
- 2024/03/01
- Product number
- 10009437
- Product name
- Kifunensine
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $260
- Updated
- 2024/03/01
KIFUNENSINE Chemical Properties,Usage,Production
Description
Historically isolated from Kitasatosporia kifunense.1?Kifunensine (CAS 109944-15-2) is an inhibitor of class I α-mannosidases which inhibit glycoprotein processing. Inhibits human endoplasmic reticulum α-1,2-mannosidase I and Golgi Class I mannosidases IA, IB and IC with Ki values of 130 and 23 nM respectively.2 Inhibition of endoplasmic reticulum a-mannosidase I activity rescues the human a-sarcoglycan R77C mutation suggesting a new pharmacological approach for limb girdle muscular dystrophy type 2D patients carrying mutations that impair a-sarcoglycan trafficking.3 Improves maturation of misfolded proteins.4
Chemical Properties
White Powder
Uses
Kifunensine is an alkaloid produced by the fungus, Kitasatosporia kifunense, and has been shown to be a weak inhibitor of aryl mannosidase. It is a unique oxamide derivative of mannojirimycin and a potent inhibitor of the glycoprotein processing enzyme mannosidase I. Kifunenesine is ineffective in inhibiting either mannosidase II or the endoplasmic reticulum (ER) a-mannosidase. It also possesses immunomodulating properties based on chemical, physicochemical and x-ray crystallographic analysis.When tested in cell culture using influenza virus-infected MDCK cells, kifunensine, at 1 mg/ml or less, caused almost complete inhibition of complex chain formation with the accumulation of Man9(GlcNAc)2. Thus, kifunensine was proven to be 50 to 100 times more effective than deoxymannojirimycin.Ph
General Description
A potent alkaloid inhibitor of mannosidase I. Does not affect mannosidase II and the endoplasmic reticulum α-mannosidase.
Biological Activity
Inhibitor of class I α -mannosidases that inhibits glycoprotein processing. Inhibits human endoplasmic reticulum α -1,2-mannosidase I and Golgi Class I mannosidases IA, IB and IC with K i values of 130 and 23 nM respectively.
Biochem/physiol Actions
Product does not compete with ATP.
storage
Store at -20°C
References
1)?Iwami et al. (1987), A new immunomodulator, FR-900494: taxonomy, fermentation, isolation, and physico-chemical and biological characteristics; J.Antibiot. (Tokyo) 40 612 2)?Elbein et al. (1990), Kifunensine, a potent inhibitor of the glycoprotein processing mannosidase I; ?J.Biol.Chem. 265 15599 3)?Bartoli et al. (2008), Mannosidase I inhibition rescues the human alpha-sarcoglycan R77C recurrent mutation; ?Hum.Mol.Genet. 17 1214 4)?Wang et al. (2011), Inhibition of endoplasmic reticulum-associated degradation rescues native folding in loss of function protein misfolding diseases; J.Biol.Chem. 286 43454
KIFUNENSINE Preparation Products And Raw materials
Raw materials
Preparation Products
KIFUNENSINE Suppliers
- Tel
- 010-82848833 400-666-7788
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 821-50328103-801 18930552037
- Fax
- 86-21-50328109
- 3bsc@sina.com
- Country
- China
- ProdList
- 15839
- Advantage
- 69
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32321
- Advantage
- 50
- Tel
- +86 21 61551611
- Fax
- +86 21 50676805
- Country
- China
- ProdList
- 9891
- Advantage
- 58
- Tel
- 400-6206333 1316706386
- Fax
- 021-50323701
- anhua.mao@aladdin-e.com
- Country
- China
- ProdList
- 25003
- Advantage
- 65
- Tel
- 13816107857
- Fax
- qq: 276312098
- sales@fortunechem-sh.com
- Country
- China
- ProdList
- 825
- Advantage
- 58
- Tel
- 18149758185 18149758185
- sales-cpd@caerulumpharma.com
- Country
- China
- ProdList
- 3466
- Advantage
- 58
- Tel
- 15221275939
- Fax
- 021-50706099
- shenlinxing@macklin.cn
- Country
- China
- ProdList
- 16166
- Advantage
- 55
- Tel
- 021-61415566 800-8193336
- orderCN@merckgroup.com
- Country
- China
- ProdList
- 51456
- Advantage
- 80
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9803
- Advantage
- 58
- Tel
- +86-400-002-6226 +86-13028896684;
- sales@rrkchem.com
- Country
- China
- ProdList
- 57422
- Advantage
- 58
- Tel
- +1-2135480471 +1-2135480471
- sales@sarms4muscle.com
- Country
- China
- ProdList
- 10473
- Advantage
- 58
- Tel
- 18818260767
- Fax
- QQ 3610331285
- sales@chemegen.com
- Country
- China
- ProdList
- 11218
- Advantage
- 58
- Tel
- 0371-55289822 18737195735
- Fax
- QQ:483339295
- 483339295@qq.com
- Country
- China
- ProdList
- 7134
- Advantage
- 58
- Tel
- 020-82000279 18988968278
- Fax
- QQ：3283937693
- sales@ubiochem.com
- Country
- China
- ProdList
- 4297
- Advantage
- 58
- Tel
- 025-85560043 15850508050
- Fax
- 025-85563444
- info@synzest.com
- Country
- China
- ProdList
- 9286
- Advantage
- 58
- Tel
- 021-58432009 400-005-6266
- Fax
- 021-58436166
- marketing1@energy-chemical.com
- Country
- China
- ProdList
- 44811
- Advantage
- 58
- Tel
- 021-69568360 18916172912
- order@med-bio.cn
- Country
- China
- ProdList
- 8140
- Advantage
- 58
- Tel
- 13675144456
- Fax
- 025-85563444
- sean.lv@synzest.com
- Country
- China
- ProdList
- 10784
- Advantage
- 58
- Tel
- 0519-85524369
- 3477467573@qq.com
- Country
- China
- ProdList
- 8617
- Advantage
- 58
- Tel
- 15865264761
- 486064515@qq.com
- Country
- China
- ProdList
- 4988
- Advantage
- 58
- Tel
- 010-60605840 15801484223;
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 29774
- Advantage
- 58
- Tel
- 13774214275
- zhouzz@univ-bio.com
- Country
- China
- ProdList
- 25000
- Advantage
- 58
- Tel
- 027-59626688 18771149750
- sales@amyjet.com
- Country
- China
- ProdList
- 3002
- Advantage
- 58
- Tel
- 0731-85561037 15386497078
- yunbang@yunbangapi.com
- Country
- China
- ProdList
- 4808
- Advantage
- 58
- Tel
- 4008200310
- marketing@tsbiochem.com
- Country
- China
- ProdList
- 24641
- Advantage
- 58
- Tel
- 010-61241352 18901327973
- 834537306@qq.com
- Country
- China
- ProdList
- 5206
- Advantage
- 58
- Tel
- 17717235263
- cindy.yang@lgcgroup.com
- Country
- China
- ProdList
- 17730
- Advantage
- 58
- Tel
- 18621169109
- market03@meryer.com
- Country
- China
- ProdList
- 27987
- Advantage
- 58
- Tel
- 18014399201
- sales@chemlab-tachizaki.com
- Country
- China
- ProdList
- 2667
- Advantage
- 58
- Tel
- 021-67187366 19901745723
- info@bwtlab.com
- Country
- China
- ProdList
- 9384
- Advantage
- 58
- Tel
- 028-81700200 13308200041
- 2851167782@qq.com
- Country
- China
- ProdList
- 11183
- Advantage
- 58
- Tel
- 15317051735
- sales@wytsci.com
- Country
- China
- ProdList
- 9731
- Advantage
- 58
- Tel
- 18003437475 18003437475
- Fax
- 1-612-656-4400
- rdname@qq.com
- Country
- China
- ProdList
- 35960
- Advantage
- 58
- Tel
- 800-3649897
- Caymanname@qq.com
- Country
- China
- ProdList
- 21643
- Advantage
- 58
- Tel
- 80-Enzo Biochem Inc. 18009420430
- info-usa@enzolifesciences.com
- Country
- China
- ProdList
- 124812
- Advantage
- 58
- Tel
- (+86) 21 2033 8288
- sigmaname@qq.com
- Country
- CHINA
- ProdList
- 292394
- Advantage
- 58
- Tel
- +8613817748580
- Fax
- 021-50175322
- cooperation@kean-chem.com
- Country
- China
- ProdList
- 40066
- Advantage
- 58
- Tel
- +86-18621343501; +undefined18621343501
- product@acmec-e.com
- Country
- China
- ProdList
- 33338
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@neobioscience.com
- Country
- CHINA
- ProdList
- 6207
- Advantage
- 58
- Tel
- --
- Fax
- --
- chenjw@absin.cn
- Country
- CHINA
- ProdList
- 6207
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@zzsrm.com
- Country
- CHINA
- ProdList
- 6650
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@wheybio.com
- Country
- CHINA
- ProdList
- 4398
- Advantage
- 58
- Tel
- --
- Fax
- --
- 2453006496@qq.com
- Country
- CHINA
- ProdList
- 6184
- Advantage
- 58
- Tel
- --
- Fax
- --
- 596799915@QQ.COM
- Country
- CHINA
- ProdList
- 2905
- Advantage
- 58
- Tel
- --
- Fax
- --
- service@neobioscience.com
- Country
- CHINA
- ProdList
- 6151
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@xarxbio.com
- Country
- China
- ProdList
- 1774
- Advantage
- 50
- Tel
- --
- Fax
- --
- 1562893815@qq.com
- Country
- CHINA
- ProdList
- 6936
- Advantage
- 58
- Tel
- --
- Fax
- --
- 344843571@qq.com
- Country
- CHINA
- ProdList
- 6318
- Advantage
- 58
- Tel
- --
- Fax
- --
- Country
- CHINA
- ProdList
- 6973
- Advantage
- 58