ChemicalBook > CAS DataBase List > TERT-BUTYL N-(1-BENZYL-2-HYDRAZINO-2-OXOETHYL)CARBAMATE

TERT-BUTYL N-(1-BENZYL-2-HYDRAZINO-2-OXOETHYL)CARBAMATE

Product Name
TERT-BUTYL N-(1-BENZYL-2-HYDRAZINO-2-OXOETHYL)CARBAMATE
CAS No.
30189-48-1
Chemical Name
TERT-BUTYL N-(1-BENZYL-2-HYDRAZINO-2-OXOETHYL)CARBAMATE
Synonyms
-tert-Butyl (1-hydrazinyl-1-oxo-3-phenylpropan-2-yl);N-(TERT-BUTOXYCARBONYL)-L-PHENYLALANINE ACID HYDRAZIDE;TERT-BUTYL N-(1-BENZYL-2-HYDRAZINO-2-OXOETHYL)CARBAMATE;(2S)-2-[(tert-Butoxycarbonyl)amino]-3-phenylpropanohydrazide;L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-, hydrazide;Tert-Butyl N-(1-Hydrazinyl-1-Oxo-3-PhenylpropaN-2-Yl)Carbamate;(S)-tert-Butyl (1-hydrazinyl-1-oxo-3-phenylpropan-2-yl)carbamate
CBNumber
CB7233946
Molecular Formula
C14H21N3O3
Formula Weight
279.33
MOL File
30189-48-1.mol
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TERT-BUTYL N-(1-BENZYL-2-HYDRAZINO-2-OXOETHYL)CARBAMATE Property

Melting point:
131-136°C
Boiling point:
505.3±50.0 °C(Predicted)
Density 
1.146±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
pka
11.42±0.46(Predicted)
form 
solid
color 
Off white
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
Hazard Note 
Irritant
HS Code 
2922500090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Ark Pharm
Product number
AK487096
Product name
(S)-tert-Butyl(1-hydrazinyl-1-oxo-3-phenylpropan-2-yl)carbamate
Purity
97%
Packaging
1g
Price
$40
Updated
2021/12/16
SynQuest Laboratories
Product number
4658-1-Z7
Product name
N-(tert-Butoxycarbonyl)-L-phenylalanine acid hydrazide
Packaging
1g
Price
$79
Updated
2021/12/16
Ark Pharm
Product number
AK487096
Product name
(S)-tert-Butyl(1-hydrazinyl-1-oxo-3-phenylpropan-2-yl)carbamate
Purity
97%
Packaging
5g
Price
$139
Updated
2021/12/16
AK Scientific
Product number
7204BA
Product name
Tert-butylN-(1-hydrazinyl-1-oxo-3-phenylpropan-2-yl)carbamate
Packaging
1g
Price
$142
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0032287
Product name
TERT-BUTYL N-(1-BENZYL-2-HYDRAZINO-2-OXOETHYL)CARBAMATE
Purity
95.00%
Packaging
1G
Price
$647.36
Updated
2021/12/16
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TERT-BUTYL N-(1-BENZYL-2-HYDRAZINO-2-OXOETHYL)CARBAMATE Chemical Properties,Usage,Production

Synthesis

51987-73-6

30189-48-1

General procedure for the synthesis of tert-butyl (S)-(1-hydrazino-1-oxo-3-phenylpropan-2-yl)carbamate from N-Boc-L-phenylalanine methyl ester: Hydrazine hydrate (170 μL, 3.44 mmol) was added to a methanol (5.4 mL) solution of N-Boc-L-phenylalanine methyl ester (300 mg, 1.07 mmol). The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the solvent was concentrated under reduced pressure by rotary evaporator. The resulting residue was first ground with hexane (2×) and then with a minimum volume of 2:3 hexane/methanol solvent mixture (2×) to afford the target product (S)-(1-hydrazino-1-oxo-3-phenylpropan-2-yl)carbamic acid tert-butyl ester in white solid form (195 mg, 65% yield). The structure of the product was confirmed by 1H NMR (CDCl3) δ 7.41-7.25 (m, 3H), 7.20 (d, J = 6.8 Hz, 2H), 4.39-4.21 (m, 1H), 3.07 (d, J = 7.0 Hz, 2H), 1.42 (s, 9H) and mass spectrometry (ESI+) m/z 280.3 ([M+H]+).

References

[1] New Journal of Chemistry, 2018, vol. 42, # 6, p. 4344 - 4351
[2] Journal of Organic Chemistry, 1995, vol. 60, # 10, p. 3112 - 3120
[3] Angewandte Chemie - International Edition, 2016, vol. 55, # 32, p. 9422 - 9426
[4] Angew. Chem., 2016, vol. 55, # 32, p. 9569 - 9574,6
[5] Patent: WO2013/192286, 2013, A1. Location in patent: Paragraph 00281

TERT-BUTYL N-(1-BENZYL-2-HYDRAZINO-2-OXOETHYL)CARBAMATE Preparation Products And Raw materials

Raw materials

Preparation Products

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TERT-BUTYL N-(1-BENZYL-2-HYDRAZINO-2-OXOETHYL)CARBAMATE Suppliers

Belgium 1 China 17 Germany 1 India 1 United Kingdom 2 United States 6 Global 28
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
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86-10-82849933
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jkinfo@jkchemical.com
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China
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ChengDu TongChuangYuan Pharmaceutical Co.Ltd
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028-83379370 13880556291
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028-87747383
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tcy@tcypharm.com
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Amadis Chemical Company Limited
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571-89925085
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0086-571-89925065
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sales@amadischem.com
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Aikon International Limited
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025-58851090 15955137747
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(6)02557626880
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Shang Hai Muse Health Tech Co., Ltd.
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021-021-61069951-8018 13262285760
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China
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Labnetwork lnc.
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+86-27-50766799 +8618062016861
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contact@labnetwork.com
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Hefei Hirisun Pharmatech Co., Ltd
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+8615056975894
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86-0551-62678551
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shawn@hirisunpharm.com
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CHINA
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Zhejiang Lianshuo Biotechnology Co., Ltd.
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18616526224
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lianshuo@vip.126.com
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Baimei Jihua (Henan) Pharmaceutical Technology Co., Ltd
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037188900765 18037465274
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QQ3430974218
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enyawanglei@sina.cn
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China
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Block Chemical Technology (Shanghai) Co., LTD
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021-20432219 13918097649
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li_jinfei@acblock-lab.com
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CONIER CHEM AND PHARMA LIMITED
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sales@conier.com
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Energy Chemical
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021-58432009 400-005-6266
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021-58436166
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marketing1@energy-chemical.com
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Bide Pharmatech Ltd.
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400-1647117 13681763483
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Guangdong Fangxin Biotechnology Co., Ltd.
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0751-2838688 13376594225
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Santa Cruz Biotechnology Inc
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021-60936350
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scbt@scbt.com
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China
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Absin Bioscience Inc.
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Atomax Chemicals Co., Ltd
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info@atomaxchem.com
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China
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30189-48-1, TERT-BUTYL N-(1-BENZYL-2-HYDRAZINO-2-OXOETHYL)CARBAMATERelated Search:

N-(tert-Butoxycarbonyl)-L-phenylalanine Boc-Glycine hydrazide H-PHE-NHNH2 TERT-BUTYL N-(1-BENZYL-2-HYDRAZINO-2-OXOETHYL)CARBAMATE

  • N-(TERT-BUTOXYCARBONYL)-L-PHENYLALANINE ACID HYDRAZIDE
  • TERT-BUTYL N-(1-BENZYL-2-HYDRAZINO-2-OXOETHYL)CARBAMATE
  • Tert-Butyl N-(1-Hydrazinyl-1-Oxo-3-PhenylpropaN-2-Yl)Carbamate
  • (2S)-2-[(tert-Butoxycarbonyl)amino]-3-phenylpropanohydrazide
  • (S)-tert-Butyl (1-hydrazinyl-1-oxo-3-phenylpropan-2-yl)carbamate
  • -tert-Butyl (1-hydrazinyl-1-oxo-3-phenylpropan-2-yl)
  • L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-, hydrazide
  • 30189-48-1