Ginsenoside Rb1

Product Name: Ginsenoside Rb1
CAS No.: 41753-43-9
Chemical Name: Ginsenoside Rb1
Synonyms: GYPENOSIDE;GINSENOSIDE GINSENOSIDE-RB1;(3beta,12beta)-20-[(6-o-beta-d-glucopyranosyl-beta-d-glucopyranosyl)oxy]-12-hydroxydammar-24-en-3-yl2-o-beta-d-glucopyranosyl-beta-d-glucopyranoside;NSC 310103;Gypenoside I;arasaponine1;gynosaponinc;Gypenoside Ⅲ;gypenosideiii;panaxsaponine
CBNumber: CB7237661
Molecular Formula: C54H92O23
Formula Weight: 1109.29
MOL File: 41753-43-9.mol

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Ginsenoside Rb1 Property

Melting point:: 197.5°C
Boiling point:: 766.35°C (rough estimate)
Density: 1.0971 (rough estimate)
refractive index: 1.6500 (estimate)
storage temp.: 2-8°C
solubility: methanol: soluble9.80 - 10.20 mg/mL, clear, colorless to faintly yellow
form: Solid
pka: 12.85±0.70(Predicted)
color: Off-White to Pale Beige
Stability:: Hygroscopic
InChI: InChI=1/C54H92O23/c1-23(2)10-9-14-54(8,77-48-44(69)40(65)37(62)29(74-48)22-70-46-42(67)38(63)34(59)26(19-55)71-46)24-11-16-53(7)33(24)25(58)18-31-51(5)15-13-32(50(3,4)30(51)12-17-52(31,53)6)75-49-45(41(66)36(61)28(21-57)73-49)76-47-43(68)39(64)35(60)27(20-56)72-47/h10,24-49,55-69H,9,11-22H2,1-8H3/t24-,25+,26+,27+,28+,29+,30-,31+,32-,33-,34+,35+,36+,37+,38-,39-,40-,41-,42+,43+,44+,45+,46+,47-,48-,49-,51-,52+,53+,54-/s3
InChIKey: GZYPWOGIYAIIPV-VOKNSFSUNA-N
SMILES: [C@]12([H])C[C@H]([C@]3([H])[C@]([H])(CC[C@@]3(C)[C@]1(C)CC[C@@]1([H])C(C)(C)[C@@H](O[C@@H]3O[C@@H]([C@@H](O)[C@H](O)[C@H]3O[C@H]3[C@H](O)[C@H]([C@H](O)[C@@H](CO)O3)O)CO)CC[C@]21C)[C@](C)(CC/C=C(\C)/C)O[C@H]1[C@H](O)[C@H]([C@H](O)[C@@H](CO[C@H]2[C@H](O)[C@H]([C@H](O)[C@@H](CO)O2)O)O1)O)O |&1:0,3,4,6,10,12,16,21,23,25,26,28,30,32,33,35,36,38,47,49,58,59,61,62,64,67,68,70,71,73,r|
LogP: 2.900 (est)
CAS DataBase Reference: 41753-43-9(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,Xi,T,F
Risk Statements: 20/21/22-39/23/24/25-23/24/25-11
Safety Statements: 26-36-45-36/37-16-7
WGK Germany: 3
RTECS: LZ5856000
HS Code: 29389090
Toxicity: oms-rat-ipr 50 mg/kg CPBTAL 24,2400,76

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: G0777
Product name: Ginsenoside-Rb1 from Panax ginseng (Korean ginseng) root
Purity: triterpenoid saponin
Packaging: 5mg
Price: $652
Updated: 2024/03/01

Sigma-Aldrich

Product number: 00170580
Product name: Ginsenoside Rb1
Purity: primary pharmaceutical reference standard
Packaging: 10mg
Price: $766
Updated: 2024/03/01

Cayman Chemical

Product number: 15319
Product name: Ginsenoside Rb1
Purity: ≥98%
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 15319
Product name: Ginsenoside Rb1
Purity: ≥98%
Packaging: 10mg
Price: $176
Updated: 2024/03/01

Sigma-Aldrich

Product number: Y0001347
Product name: Ginsenoside Rb1
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: y0001347
Price: $220
Updated: 2024/03/01

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Ginsenoside Rb1 Chemical Properties,Usage,Production

Description

Ginsenoside Rb1, a glycosylated PPD type ginsenoside with two sugars linked to C-3 and two sugars linked to C-20, is the major active constituent of American ginseng. Studies have demonstrated the anti-aging effects of ginsenoside Rb1 at both animal and cell levels. 20-O-β-D-glucopyranosyl-20(S)-protopanaxadiol (20GPPD) is the major ingredient of ginsenoside Rb1, which has been shown to increase HAS2 expression by phosphorylating ERK and AKT signaling in human keratinocytes in a dose-dependent manner in vitro.

Uses

A major bioactive component of panax ginseng that promotes neurotransmitter release by modulating phosphorylation of synapsins through a cAMP-dependent protein kinase pathway. It has been reported to display immunostimulatory and anticancer effects.

Uses

Reference standard in the analysis of herbal medicinal products.

Definition

ChEBI: Ginsenoside Rb1 is a ginsenoside found in Panax ginseng and Panax japonicus var. major that is ginsenoside Rd in which the beta-D-glucopyranoside group at position 20 is replaced by a beta-D-glucopyranosyl-beta-D-glucopyranoside group. It has a role as a neuroprotective agent, an anti-obesity agent, an anti-inflammatory drug, an apoptosis inhibitor, a radical scavenger and a plant metabolite. It is a ginsenoside, a glycoside and a tetracyclic triterpenoid. It is functionally related to a ginsenoside Rd.

benefits

Ginsenoside Rb1 (G-Rb1) is a tetracyclic triterpenoid mainly obtained from the roots or stems of Panax notoginseng and ginseng by extraction and purification. It is one of the main bioactive compounds of ginseng with minimal toxicity and neurotrophic and neuroprotective effects on brain injury. G-Rb1 promotes hippocampal nerve regeneration, enhances learning and memory, and has anti-aging and anti-fatigue effects. In addition, it activates antioxidants, stimulates the immune system, has anti-apoptotic activity, and maintains cell adenosine triphosphate (ATP) levels[1].

General Description

Ginsenoside Rb1 (Gypenoside Ⅲ) is a protopanaxadiol that has diverse in vitro and in vivo effects, including neuroprotective, anti-inflammatory, and anti-obesity actions. Ginsenoside Rb1, a main constituent of the root of Panax ginseng, inhibits Na+, K+-ATPase activity with IC50 of 6.3±1.0 μM. Ginsenoside also inhibits IRAK-1 activation and phosphorylation of NF-κB p65. Ginsenoside Rb1 reduces the expressions of TLR3, TLR4 and TRAF-6, and down-regulates the levels of TNF-α, IFN-β and iNOS.

Biochem/physiol Actions

Triterpene saponin found in ginseng.

Safety Profile

Poison by intravenous route. Moderately toxic by intraperitoneal route. Mutation data reported. Whenheated to decomposition it emits acrid smoke and irritating fumes.

target

p38MAPK | JNK | GLUT | Akt | IFN-γ | IL Receptor | GSK-3 | HO-1 | PKA | Estrogen receptor | Progestogen receptor

References

[1] Shan Wen. “Ginsenoside Rb1 improves energy metabolism after spinal cord injury.” Neural Regeneration Research 18 6 (2023): 1332–1338.

Ginsenoside Rb1 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Ginsenoside Rb1 manufacturers

Shaanxi Cuikang Pharmaceutical Technology Co., Ltd

Product: Ginsenoside Rb1 41753-43-9
Price: US $0.00/kg
Min. Order: 0.1kg
Purity: 50%-98% HPLC
Supply Ability: 100kg
Release date: 2024-03-14

Shaanxi Haibo Biotechnology Co., Ltd

Product: Ginsenoside Rb1 41753-43-9
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 2000ton
Release date: 2023-08-21

Henan Fengda Chemical Co., Ltd

Product: Ginsenoside Rb1 41753-43-9
Price: US $34.00-1.40/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-03-26

41753-43-9, Ginsenoside Rb1 Related Search:

Ginsenoside Rg2 TRIBULOSIDE GINSENOSIDE RE Ginsenoside Rg1 Ginsenoside Re Ginsenoside Rh2 GinsenosideRo 20(R)-Ginsenoside Rg3 Ginsenoside Rd Ginsenoside Rb3 (CAS#68403-26-8),GINSENOSIDE RB3 GINSENOSIDE RB2,GINSENOSIDE Rb2 hplc,GINSENOSIDE RB2 WITH HPLC Panaxadiol Panaxatriol Ginsenoside Rg3 Ginsenoside-Rg5 Ginsenoside Rh1 Ginsenoside Rk3 GINSENOSIDEF1

GINSENOSIDE GINSENOSIDE-RB1

GINSENOSIDE RB1

GINSENOSIDE RBL

(3beta,12beta)-20-[(6-o-beta-d-glucopyranosyl-beta-d-glucopyranosyl)oxy]-12-hydroxydammar-24-en-3-yl2-o-beta-d-glucopyranosyl-beta-d-glucopyranoside

2-O-beta-glucopyranosyl-(3beta,12beta)-20-[(6-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]-12-hydroxydammar-24-en-3-yl-beta-D-glucopyranoside

Ginsenoside Rb1 std.

ginsenoside-rb1from panax quinquefolium (american ginseng)root

Ginsenoside Rb1 (CAS# 41753-43-9)

GinsenosideRB1,SanchinosideE1

GINSENOSIDE Rb1 hplc

Gensenoside Rb1

GINSENOSIDE RB1 WITH HPLC

glucopyranosyl-β-D-glucopyranosyl)oxy]-12-

hydroxydammar-24-en-3-yl2-O-β-D-glucopyra

Notoginsenoside Rb1

Panaxoside Rb1

β-D-Glucopyranoside, (3β,12β)-20-[(6-O-β-D-

Gypenoside I

hydroxydammar-24-en-3-yl O-6-deoxy-α-L-

mannopyranosyl-(1→6)-O-[β-D-

(20S)-3β-[2-O-(β-D-Glucopyranosyl)-β-D-glucopyranosyloxy]-20-[6-O-(β-D-glucopyranosyl)-β-D-glucopyranosyloxy]dammara-24-ene-12β-ol

[20-[(6-O-β-D-Glucopyranosyl-β-D-glucopyranosyl)oxy]-12β-hydroxydammar-24-en-3β-yl]2-O-β-D-glucopyranosyl-β-D-glucopyranoside

3β-[2-O-(β-D-Glucopyranosyl)-β-D-glucopyranosyloxy]-20-[6-O-(β-D-glucopyranosyl)-β-D-glucopyranosyloxy]dammara-24-ene-12β-ol

ginsenoside-Rb1 standard

Ginsenoside Rb1 41753-43-9

(3-beta,12-beta)-20-((6-o-beta-d-glucopyranosyl-beta-d-beta-d-glucopyranosid

arasaponine1

glucopyranosyl)oxy)-12-hydroxydammar-24-en-3-yl2-o-beta-d-glucopyranosyl-

gynosaponinc

gypenosideiii

panaxsaponine

pseudoginsenosided

SANCHINOSIDE E1

GYPENOSIDE

Ginsenoside Rb1 ,98%

(3β,12β)-20-[(6-O-β-D-Glucopyranosyl-β-D-glucopyranosyl)oxy]-12-hydroxydaMMar-24-en-3-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside

Purity of Ginsenoside Rg1

NSC 310103

Sanchinoside Rb1

Ginsenoside Rb1, froM Panax ginseng

Ginsenoside Rb1 (saponin of panax ginseng)

Ginsenoside-Rb1 from Panax ginseng (Korean ginseng) root

2-O-β-Glucopyranosyl-(3β,12β)-20-[(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-12-hydroxydammar-24-en-3-yl β-D-glucopyranoside

Ginsenoside Rb1, 98%, from Panax ginseng C. A. Mey.

(3beta,12beta)-20-[(6-O-beta-D-Glucopyranosyl-beta-D-glucopyranosyl)oxy]-12-hydroxydammar-24-en-3-yl2-O-beta-D-glucopyranosyl-beta-D-glucopyranosi

Ginsenoside Rb1 CRS

Ginsenoside Rb1 RS

Gypenoside Ⅲ

β-D-Glucopyranoside, (3β,12β)-20-[(6-O-β-D-glucopyranosyl-β-D-glucopyranosyl)oxy]-12-hydroxydammar-24-en-3-yl 2-O-β-D-glucopyranosyl-

(2R,3R,4S,5S,6R)-2-[[(2R,3S,4S,5R,6S)-6-[(2S)-2-[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-3-[(2R,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-12-hydroxy-4,4,8,10,14-pentamethyl-2,3,

(2R,3R,4S,5S,6R)-2-[[(2R,3S,4S,5R,6S)-6-[(2S)-2-[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-3-[(2R,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-12-hydroxy-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-methylhept-5-en-2-yl]oxy-3,4,5-trihydroxyoxan-2-yl]methoxy]-6-(hydroxymethyl)oxane-3,4,5-triol

(2S,3R,4S,5S,6R)-2-(((2R,3R,4S,5S,6R)-4,5-Dihydroxy-2-(((3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-hydroxy-4,4,8,10,14-pentamethyl-17-((S)-6-methyl-2-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-((((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)hept-5-en-2-yl)hexadecahydro-1H-cyclopenta[a]phenanthren-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

Rb1 Ginsenoside Rb1

Ginsenoside Rb1-RM

Ginsenoside Rb1(AS)

Ginsenoside Rb1(P)

41753-43-9

41753-53-9