Levomefolic Acid
Description Mechanism Medical application Storage- Product Name
- Levomefolic Acid
- CAS No.
- 31690-09-2
- Chemical Name
- Levomefolic Acid
- Synonyms
- 5-MTHF;L-5-Methyltetrahydrofolate;L-5-Methyltetrahydrofolic acid;(6S)-5-Methyltetrahydrofolic acid;N-[4-[[[(6S)-2-Amino-5-methyl-1,4,5,6,7,8-hexahydro-4-oxopteridine-6-yl]methyl]amino]benzoyl]-L-glutamic acid;l-N5;L-methyl acid;5lLCH3-folateH4;Unii-8S95dh25xc;Levomefolic acid
- CBNumber
- CB72379121
- Molecular Formula
- C20H25N7O6
- Formula Weight
- 459.46
- MOL File
- 31690-09-2.mol
Levomefolic Acid Property
- Melting point:
- 215-218oC
- Density
- 1.62
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Aqueous Base (Slightly, Heated, Sonicated), DMSO (Slightly)
- pka
- 3.51±0.10(Predicted)
- form
- Solid
- color
- Off-White to Light Green
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- L0335
- Product name
- Levomefolic Acid
- Packaging
- 50MG
- Price
- $214
- Updated
- 2024/03/01
- Product number
- L0335
- Product name
- Levomefolic Acid
- Packaging
- 250MG
- Price
- $644
- Updated
- 2024/03/01
- Product number
- 015555
- Product name
- Levomefolic Acid
- Packaging
- 5mg
- Price
- $496
- Updated
- 2021/12/16
- Product number
- 281235
- Product name
- Levomefolic acid
- Packaging
- 10g
- Price
- $1238
- Updated
- 2021/12/16
- Product number
- I0785-77
- Product name
- L-N5-
- Packaging
- 1mg
- Price
- $355
- Updated
- 2021/12/16
Levomefolic Acid Chemical Properties,Usage,Production
Description
Levomefolic Acid is a natural, active form of folic acid used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine among other functions. It is a coenzymated form of folic acid. It has been proposed for treatment of cardiovascular disease.
Mechanism
It is synthesized in the absorptive cells of the small intestine from polyglutamylated dietary folate. It is a methylated derivative of tetrahydrofolate. Levomefolic acid is generated by methylenetetrahydrofolate reductase (MTHFR) from 5,10-methylenetetrahydrofolate (MTHF) and used to recycle homocysteine back to methionine by methionine synthase (MS).
Medical application
Levomefolic acid (5-MTHF) is the natural, active form of folic acid used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine among other functions. IC50 value: Target: Folate analogLevomefolic acid has been proposed for treatment of cardiovascular disease and advanced cancers such as breast and colorectal cancers. Levomefolic acid (5-MTHF) has the prominent antioxidant activity. A high dose of 5-MTHF or folic acid does not influence Natural killer (NK) cell function in vitro.
Preliminary research suggests that levomefolic acid (L-methylfolate) taken with a first-line antidepressant may provide an adjunctive antidepressant effect for individuals who do not respond or have only a partial therapeutic response to SSRI or SNRI medication,and might be a more cost-effective adjunctive agent than second-generation antipsychotics.
Storage
Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
Uses
A natural, active form of folic acid used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine among other functions. It is a coenzymated form of folic acid. It has been proposed for treatment of cardiovascular disease.
Uses
As a natural, active form of folic acid, Levomefolic Acid can be used at the cellular level for DNA reproduction, the cysteine cycle and the regulation of homocysteine among other functions. It is a coenzymated form of folic acid and a more bioavailable alternative in dietary supple
Definition
ChEBI: 5-methyltetrahydrofolic acid is a tetrahydrofolic acid that is 5,6,7,8-tetrahydrofolic acid substituted by a methyl group at position 5. It has a role as a human metabolite. It is functionally related to a 5,6,7,8-tetrahydrofolic acid. It is a conjugate acid of a 5-methyltetrahydrofolate(2-).
Levomefolic Acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Levomefolic Acid manufacturers
- Product
- Levomefolic Acid 31690-09-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 3000kg
- Release date
- 2023-12-08
- Product
- Levomefolic Acid 31690-09-2
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99.6%
- Supply Ability
- 100000
- Release date
- 2024-04-25
- Product
- L-5-Methyltetrahydrofolate 31690-09-2
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 2000ton
- Release date
- 2023-09-04