4-AMINO-6-CHLOROPYRIMIDINE-5-CARBONITRILE

Product Name: 4-AMINO-6-CHLOROPYRIMIDINE-5-CARBONITRILE
CAS No.: 60025-09-4
Chemical Name: 4-AMINO-6-CHLOROPYRIMIDINE-5-CARBONITRILE
Synonyms: EOS-61673;4-amino-6-chloro-pyrimidi...;4-Amino-6-chloro-5-cyanopyrimidine;4-AMINO-6-CHLOROPYRIMIDINE-5-CARBONITRIL;4-AMINO-6-CHLOROPYRIMIDINE-5-CARBONITRILE;4-Amino-6-chloro-5-pyrimidinecarbonitrile;5-Pyrimidinecarbonitrile, 4-amino-6-chloro-;4-Amino-6-chloro-5-cyanopyrimidine, 4-Amino-6-chloro-5-cyano-1,3-diazine
CBNumber: CB72448629
Molecular Formula: C5H3ClN4
Formula Weight: 154.56
MOL File: 60025-09-4.mol

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4-AMINO-6-CHLOROPYRIMIDINE-5-CARBONITRILE Property

Melting point:: 200℃ (DEC.)
Boiling point:: 402.4±45.0 °C(Predicted)
Density: 1.53
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: -0.58±0.10(Predicted)
Appearance: White to yellow Solid
InChI: InChI=1S/C5H3ClN4/c6-4-3(1-7)5(8)10-2-9-4/h2H,(H2,8,9,10)
InChIKey: MAVMFCKRFRCMLE-UHFFFAOYSA-N
SMILES: C1=NC(Cl)=C(C#N)C(N)=N1

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Safety

HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Usbiological

Product number: 260039
Product name: 4-Amino-6-chloropyrimidine-5-carbonitrile
Packaging: 100mg
Price: $359
Updated: 2021/12/16

TRC

Product number: A617688
Product name: 4-Amino-6-chloropyrimidine-5-carbonitrile
Packaging: 100mg
Price: $75
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA33037
Product name: 4-Amino-6-chloropyrimidine-5-carbonitrile
Packaging: 1g
Price: $367.5
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0344400
Product name: 4-AMINO-6-CHLOROPYRIMIDINE-5-CARBONITRILE
Purity: 95.00%
Packaging: 5MG
Price: $496.74
Updated: 2021/12/16

Matrix Scientific

Product number: 068912
Product name: 4-Amino-6-chloropyrimidine-5-carbonitrile
Purity: >95%
Packaging: 1g
Price: $499
Updated: 2021/12/16

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4-AMINO-6-CHLOROPYRIMIDINE-5-CARBONITRILE Chemical Properties,Usage,Production

Uses

4-Amino-6-chloropyrimidine-5-carbonitrile is a useful research reagent for organic synthesis and other chemical processes.

Synthesis

5305-45-3

60025-09-4

The general procedure for the synthesis of 4-amino-6-chloropyrimidine-5-carbonitrile using 4,6-dichloropyrimidine-5-carbonitrile as starting material was as follows: 4,6-dichloropyrimidine-5-carbonitrile (4.8 g, 27.59 mmol) was suspended in 30 mL of dioxane and the mixture was cooled to 0 °C in an ice bath. A methanol solution of ammonia (7 N, 20 mL, 140 mmol) was added slowly and dropwise over a period of 20 minutes. After the dropwise addition, the reaction mixture was continued to be stirred at 0 °C for 30 min. After completion of the reaction, the solvent was removed by rotary evaporator. The crude product was redissolved in tetrahydrofuran, at which point a precipitate was generated, and the precipitate was collected by filtration and washed with additional tetrahydrofuran. The organic solvent was again removed under reduced pressure by rotary evaporator. Finally, the residue was purified using the SP1 purification system (eluent: 20%-80% hexane-ethyl acetate gradient) to afford 2.38 g (56% yield) of the target compound, 4-amino-6-chloropyrimidine-5-carbonitrile, as a white solid with 100% purity.LRMS (m/z): 155 (M + 1)+.

References

[1] Patent: WO2014/60432, 2014, A1. Location in patent: Page/Page column 159
[2] Patent: WO2010/151735, 2010, A2. Location in patent: Page/Page column 57
[3] Patent: US2011/152296, 2011, A1. Location in patent: Page/Page column 15
[4] Patent: US2011/245257, 2011, A1. Location in patent: Page/Page column 15
[5] Patent: WO2012/68343, 2012, A1. Location in patent: Page/Page column 29

4-AMINO-6-CHLOROPYRIMIDINE-5-CARBONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-AMINO-6-CHLOROPYRIMIDINE-5-CARBONITRILE Suppliers

China 127 India 1 United Kingdom 2 United States 6 Global 136

Wuhan Luyi New Material Co., Ltd.

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Tongchuang Pharma(Suzhou). Co., Ltd.

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View Lastest Price from 4-AMINO-6-CHLOROPYRIMIDINE-5-CARBONITRILE manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 4-AMINO-6-CHLOROPYRIMIDINE-5-CARBONITRILE 60025-09-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-26

Shaanxi Dideu Medichem Co. Ltd

Product: 4-AMINO-6-CHLOROPYRIMIDINE-5-CARBONITRILE 60025-09-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20T
Release date: 2020-05-15

Career Henan Chemical Co

Product: 4-AMINO-6-CHLOROPYRIMIDINE-5-CARBONITRILE 60025-09-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2019-06-24

60025-09-4, 4-AMINO-6-CHLOROPYRIMIDINE-5-CARBONITRILERelated Search:

4-AMINO-6-CHLORO-PYRIMIDINE-5-CARBALDEHYDE 4-Amino-6-chloropyrimidine 4-CHLORO-2-(METHYLTHIO)-6-(4-METHYLPHENYLAMINO)PYRIMIDINE-5-CARBONITRILE 4-AMINO-6-CHLORO-2-METHYLPYRIMIDINE-5-CARBONITRILE 4-CHLORO-2-(METHYLTHIO)-6-[3-(TRIFLUOROMETHYL)ANILINO]PYRIMIDINE-5-CARBONITRILE 4-CHLORO-2-METHYLSULFANYL-6-PHENYLAMINO-PYRIMIDINE-5-CARBONITRILE 4-CHLORO-6-(4-CHLOROANILINO)-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE 4-AMINO-6-CHLOROPYRIMIDINE-5-CARBONITRILE

4-AMINO-6-CHLOROPYRIMIDINE-5-CARBONITRILE

4-amino-6-chloro-pyrimidi...

4-Amino-6-chloro-5-cyanopyrimidine, 4-Amino-6-chloro-5-cyano-1,3-diazine

4-Amino-6-chloro-5-cyanopyrimidine

5-Pyrimidinecarbonitrile, 4-amino-6-chloro-

4-Amino-6-chloro-5-pyrimidinecarbonitrile

EOS-61673

4-AMINO-6-CHLOROPYRIMIDINE-5-CARBONITRIL

60025-09-4

Heterocycle-Pyrimidine series