ChemicalBook > CAS DataBase List > 4-AMINO-6-CHLOROPYRIMIDINE-5-CARBONITRILE
4-AMINO-6-CHLOROPYRIMIDINE-5-CARBONITRILE
- Product Name
- 4-AMINO-6-CHLOROPYRIMIDINE-5-CARBONITRILE
- CAS No.
- 60025-09-4
- Chemical Name
- 4-AMINO-6-CHLOROPYRIMIDINE-5-CARBONITRILE
- Synonyms
- EOS-61673;4-amino-6-chloro-pyrimidi...;4-Amino-6-chloro-5-cyanopyrimidine;4-AMINO-6-CHLOROPYRIMIDINE-5-CARBONITRIL;4-AMINO-6-CHLOROPYRIMIDINE-5-CARBONITRILE;4-Amino-6-chloro-5-pyrimidinecarbonitrile;5-Pyrimidinecarbonitrile, 4-amino-6-chloro-;4-Amino-6-chloro-5-cyanopyrimidine, 4-Amino-6-chloro-5-cyano-1,3-diazine
- CBNumber
- CB72448629
- Molecular Formula
- C5H3ClN4
- Formula Weight
- 154.56
- MOL File
- 60025-09-4.mol
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4-AMINO-6-CHLOROPYRIMIDINE-5-CARBONITRILE Property
- Melting point:
- 200℃ (DEC.)
- Boiling point:
- 402.4±45.0 °C(Predicted)
- Density
- 1.53
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- -0.58±0.10(Predicted)
- Appearance
- White to yellow Solid
- InChI
- InChI=1S/C5H3ClN4/c6-4-3(1-7)5(8)10-2-9-4/h2H,(H2,8,9,10)
- InChIKey
- MAVMFCKRFRCMLE-UHFFFAOYSA-N
- SMILES
- C1=NC(Cl)=C(C#N)C(N)=N1
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Safety
- HS Code
- 2933599590
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Usbiological
- Product number
- 260039
- Product name
- 4-Amino-6-chloropyrimidine-5-carbonitrile
- Packaging
- 100mg
- Price
- $359
- Updated
- 2021/12/16
TRC
- Product number
- A617688
- Product name
- 4-Amino-6-chloropyrimidine-5-carbonitrile
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FA33037
- Product name
- 4-Amino-6-chloropyrimidine-5-carbonitrile
- Packaging
- 1g
- Price
- $367.5
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- HCH0344400
- Product name
- 4-AMINO-6-CHLOROPYRIMIDINE-5-CARBONITRILE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.74
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 068912
- Product name
- 4-Amino-6-chloropyrimidine-5-carbonitrile
- Purity
- >95%
- Packaging
- 1g
- Price
- $499
- Updated
- 2021/12/16
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4-AMINO-6-CHLOROPYRIMIDINE-5-CARBONITRILE Chemical Properties,Usage,Production
Uses
4-Amino-6-chloropyrimidine-5-carbonitrile is a useful research reagent for organic synthesis and other chemical processes.
Synthesis
5305-45-3
60025-09-4
The general procedure for the synthesis of 4-amino-6-chloropyrimidine-5-carbonitrile using 4,6-dichloropyrimidine-5-carbonitrile as starting material was as follows: 4,6-dichloropyrimidine-5-carbonitrile (4.8 g, 27.59 mmol) was suspended in 30 mL of dioxane and the mixture was cooled to 0 °C in an ice bath. A methanol solution of ammonia (7 N, 20 mL, 140 mmol) was added slowly and dropwise over a period of 20 minutes. After the dropwise addition, the reaction mixture was continued to be stirred at 0 °C for 30 min. After completion of the reaction, the solvent was removed by rotary evaporator. The crude product was redissolved in tetrahydrofuran, at which point a precipitate was generated, and the precipitate was collected by filtration and washed with additional tetrahydrofuran. The organic solvent was again removed under reduced pressure by rotary evaporator. Finally, the residue was purified using the SP1 purification system (eluent: 20%-80% hexane-ethyl acetate gradient) to afford 2.38 g (56% yield) of the target compound, 4-amino-6-chloropyrimidine-5-carbonitrile, as a white solid with 100% purity.LRMS (m/z): 155 (M + 1)+.
References
[1] Patent: WO2014/60432, 2014, A1. Location in patent: Page/Page column 159
[2] Patent: WO2010/151735, 2010, A2. Location in patent: Page/Page column 57
[3] Patent: US2011/152296, 2011, A1. Location in patent: Page/Page column 15
[4] Patent: US2011/245257, 2011, A1. Location in patent: Page/Page column 15
[5] Patent: WO2012/68343, 2012, A1. Location in patent: Page/Page column 29
4-AMINO-6-CHLOROPYRIMIDINE-5-CARBONITRILE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-AMINO-6-CHLOROPYRIMIDINE-5-CARBONITRILE manufacturers
Henan Aochuang Chemical Co.,Ltd.
- Product
- 4-AMINO-6-CHLOROPYRIMIDINE-5-CARBONITRILE 60025-09-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-26
Shaanxi Dideu Medichem Co. Ltd
- Product
- 4-AMINO-6-CHLOROPYRIMIDINE-5-CARBONITRILE 60025-09-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2020-05-15
Career Henan Chemical Co
- Product
- 4-AMINO-6-CHLOROPYRIMIDINE-5-CARBONITRILE 60025-09-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2019-06-24
60025-09-4, 4-AMINO-6-CHLOROPYRIMIDINE-5-CARBONITRILERelated Search:
4-AMINO-6-CHLORO-PYRIMIDINE-5-CARBALDEHYDE
4-Amino-6-chloropyrimidine
4-CHLORO-2-(METHYLTHIO)-6-(4-METHYLPHENYLAMINO)PYRIMIDINE-5-CARBONITRILE
4-AMINO-6-CHLORO-2-METHYLPYRIMIDINE-5-CARBONITRILE
4-CHLORO-2-(METHYLTHIO)-6-[3-(TRIFLUOROMETHYL)ANILINO]PYRIMIDINE-5-CARBONITRILE
4-CHLORO-2-METHYLSULFANYL-6-PHENYLAMINO-PYRIMIDINE-5-CARBONITRILE
4-CHLORO-6-(4-CHLOROANILINO)-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE
4-AMINO-6-CHLOROPYRIMIDINE-5-CARBONITRILE