2-CHLORO-5-IODO-3-(TRIFLUOROMETHYL)-PYRIDINONE

Product Name: 2-CHLORO-5-IODO-3-(TRIFLUOROMETHYL)-PYRIDINONE
CAS No.: 887707-25-7
Chemical Name: 2-CHLORO-5-IODO-3-(TRIFLUOROMETHYL)-PYRIDINONE
Synonyms: 2-Chloro-5-iodo-3-(trifluoromethyl);Pyridine, 2-chloro-5-iodo-3-(trifluoromethyl)-;2-CHLORO-5-IODO-3-(TRIFLUOROMETHYL)-PYRIDINONE;6-chloro-3-iodo-5-(trifluoroMethyl)pyridin-4(3H)-one;2-CHLORO-5-IODO-3-(TRIFLUOROMETHYL)-PYRIDINONE ISO 9001：2015 REACH
CBNumber: CB72449646
Molecular Formula: C6H2ClF3IN
Formula Weight: 307.44
MOL File: 887707-25-7.mol

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2-CHLORO-5-IODO-3-(TRIFLUOROMETHYL)-PYRIDINONE Property

Melting point:: 43℃
Boiling point:: 261℃
Density: 2.046
Flash point:: 112℃
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
form: Solid
pka: -3.82±0.10(Predicted)
Water Solubility: Slightly soluble in water.
Sensitive: Light Sensitive

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Safety

HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: C381645
Product name: 2-Chloro-5-iodo-3-(trifluoromethyl)pyridine
Packaging: 500mg
Price: $75
Updated: 2021/12/16

AK Scientific

Product number: W9181
Product name: 2-Chloro-5-iodo-3-(trifluoromethyl)pyridine
Packaging: 5g
Price: $102
Updated: 2021/12/16

Matrix Scientific

Product number: 057412
Product name: 2-Chloro-5-iodo-3-(trifluoromethyl)pyridine
Purity: 95%
Packaging: 1g
Price: $103
Updated: 2021/12/16

Oakwood

Product number: 092503
Product name: 2-Chloro-5-iodo-3-(trifluoromethyl)pyridine
Packaging: 25g
Price: $250
Updated: 2021/12/16

Apolloscientific

Product number: PC450103
Product name: 2-Chloro-5-iodo-3-(trifluoromethyl)pyridine
Packaging: 250mg
Price: $40
Updated: 2021/12/16

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2-CHLORO-5-IODO-3-(TRIFLUOROMETHYL)-PYRIDINONE Chemical Properties,Usage,Production

Uses

It is used as pharmaceutical intermediate and as an advanced chemical intermediate.

Synthesis

887707-23-5

887707-25-7

General procedure for the synthesis of 2-chloro-5-iodo-3-(trifluoromethyl)pyridine from 2-hydroxy-5-iodo-3-(trifluoromethyl)pyridine: In a microwave reaction vial, 5-iodo-3-trifluoromethyl-2-pyridinol (1 g, 3.47 mmol) was added to a pre-cooled mixture of POCl3 (1.60 mL) and DMF (1 mL). After sealing the vial, the reaction was heated at 110 °C for 20 min. Upon completion of the reaction, the mixture was cooled to room temperature and slowly poured into ice water. At this point, the product precipitated as a precipitate. The precipitate was collected by filtration, washed with cold water and dried to give 661 mg of the product in the form of a light brown powder in 62% yield. The structure of the product was determined by 1H NMR (500 MHz, CDCl3) δ 8.32 (d, J = 2.0 Hz, 1H), 8.81 (d, J = 2.0 Hz, 1H) and 13C NMR (250 MHz, CDCl3) δ 89.4, 121.2 (q, JC-F = 273.3 Hz), 126.8 (q, JC-F = 33.6 Hz), 144.34, 148.5, 158.7 for confirmation.

References

[1] Patent: WO2015/100613, 2015, A1. Location in patent: Page/Page column 17; 18
[2] Patent: WO2015/100617, 2015, A1. Location in patent: Page/Page column 36; 37
[3] Patent: WO2008/119015, 2008, A2. Location in patent: Page/Page column 48-49
[4] Patent: JP2016/11315, 2016, A. Location in patent: Paragraph 0084
[5] Patent: US9388159, 2016, B2. Location in patent: Page/Page column 20; 21

2-CHLORO-5-IODO-3-(TRIFLUOROMETHYL)-PYRIDINONE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-CHLORO-5-IODO-3-(TRIFLUOROMETHYL)-PYRIDINONE Suppliers

Canada 1 China 102 India 3 United Kingdom 2 United States 10 Global 118

Apollo Scientific Ltd.

Tel: --
Fax: --
Email: sales@apolloscientific.co.uk
Country: United Kingdom
ProdList: 6084
Advantage: 88

Fluorochem Ltd.

Tel: --
Fax: --
Email: enquiries@fluorochem.co.uk
Country: United Kingdom
ProdList: 6401
Advantage: 74

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View Lastest Price from 2-CHLORO-5-IODO-3-(TRIFLUOROMETHYL)-PYRIDINONE manufacturers

Suzhou Nordica Biopharma CO.,LTD

Product: 2-chloro-5-iodo-3-(trifluoromethyl)pyridine 887707-25-7
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 1 tons
Release date: 2024-11-15

Dideu Industries Group Limited

Product: 2-CHLORO-5-IODO-3-(TRIFLUOROMETHYL)-PYRIDINONE 887707-25-7
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-08-30

Career Henan Chemical Co

Product: 2-CHLORO-5-IODO-3-(TRIFLUOROMETHYL)-PYRIDINONE 887707-25-7
Price: US $5.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2020-01-12

887707-25-7, 2-CHLORO-5-IODO-3-(TRIFLUOROMETHYL)-PYRIDINONERelated Search:

3-IODO-1H-PYRIDIN-4-ONE 2-CHLORO-5-IODO-3-(TRIFLUOROMETHYL)-PYRIDINONE

2-CHLORO-5-IODO-3-(TRIFLUOROMETHYL)-PYRIDINONE

6-chloro-3-iodo-5-(trifluoroMethyl)pyridin-4(3H)-one

2-Chloro-5-iodo-3-(trifluoromethyl)

Pyridine, 2-chloro-5-iodo-3-(trifluoromethyl)-

2-CHLORO-5-IODO-3-(TRIFLUOROMETHYL)-PYRIDINONE ISO 9001：2015 REACH

887707-25-7

C6H2ClF3INO

Fluorine series