2-AMINO-6-BROMOTHIAZOLO[4,5-B]PYRAZINE

Product Name: 2-AMINO-6-BROMOTHIAZOLO[4,5-B]PYRAZINE
CAS No.: 112342-72-0
Chemical Name: 2-AMINO-6-BROMOTHIAZOLO[4,5-B]PYRAZINE
Synonyms: 2-AMINO-6-BROMOTHIAZOLO[4,5-B]PYRAZINE;Thiazolo[4,5-b]pyrazin-2-amine, 6-bromo-
CBNumber: CB72452796
Molecular Formula: C5H3BrN4S
Formula Weight: 231.07
MOL File: 112342-72-0.mol

More

Less

2-AMINO-6-BROMOTHIAZOLO[4,5-B]PYRAZINE Property

Boiling point:: 366℃
Density: 2.078
Flash point:: 175℃
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: -3.63±0.50(Predicted)
Appearance: Off-white to yellow Solid

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

TRC

Product number: A595130
Product name: 2-Amino-6-bromothiazolo[4,5-b]pyrazine
Packaging: 10g
Price: $1865
Updated: 2021/12/16

AK Scientific

Product number: X9005
Product name: 2-Amino-6-bromothiazolo[4,5-b]pyrazine
Packaging: 250mg
Price: $174
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA153730
Product name: 2-Amino-6-bromothiazolo[4,5-b]pyrazine
Packaging: 25mg
Price: $200
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA153730
Product name: 2-Amino-6-bromothiazolo[4,5-b]pyrazine
Packaging: 50mg
Price: $300
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA153730
Product name: 2-Amino-6-bromothiazolo[4,5-b]pyrazine
Packaging: 100mg
Price: $400
Updated: 2021/12/16

More

Less

2-AMINO-6-BROMOTHIAZOLO[4,5-B]PYRAZINE Chemical Properties,Usage,Production

Uses

2-Amino-6-bromothiazolo[4,5-b]pyrazine is derived from 2-Amino-3,5-dibromopyrazine (A604635), which is used in the preparation of conjugated polymers for neurotoxin detection and is an intermediate in the preparation of rho kinase (ROCK) inhibitors.

Synthesis

112342-70-8

112342-72-0

General procedure for the synthesis of 6-bromothiazolo[4,5-b]pyrazin-2-amine from ethyl (6-bromothiazolo[4,5-b]pyrazin-2-yl)carbamate: 2 N aqueous sodium hydroxide (7.91) was added to a methanolic (8 mL) suspension of ethyl (6-bromothiazolo[4,5-b]pyrazin-2-yl)carbamate (480 mg, 1.58 mmol). mL, 15.83 mmol). The mixture was heated under reflux conditions for 5 hours. Upon completion of the reaction, the mixture was acidified with 2 N HCl to pH < 7. Subsequently, the reaction mixture was neutralized with saturated sodium bicarbonate solution and extracted with ethyl acetate (3 × 10 mL). The organic layers were combined, washed sequentially with saturated sodium bicarbonate solution and saturated aqueous sodium chloride solution, and dried over anhydrous sodium sulfate. The organic phase was concentrated under reduced pressure to give the crude product. The precipitate was collected by filtration to afford 6-bromothiazolo[4,5-b]pyrazin-2-amine (334 mg, 91.0% yield) as a pale yellow solid.1H-NMR (DMSO-d6) δ: 8.37 (s, 1H), 8.59 (brs, 2H).

References

[1] Patent: EP2351744, 2011, A1. Location in patent: Page/Page column 74
[2] Heterocycles, 1987, vol. 26, # 3, p. 689 - 697

2-AMINO-6-BROMOTHIAZOLO[4,5-B]PYRAZINE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

2-AMINO-6-BROMOTHIAZOLO[4,5-B]PYRAZINE Suppliers

China 54 India 1 Switzerland 1 United Kingdom 2 United States 6 Global 64

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10186
Advantage: 62

skychemical Co.Ltd

Tel: 021-20958197 20965099
Fax: 021-20960837
Email: sales@skychemical.com
Country: China
ProdList: 1183
Advantage: 57

Kohn & Shawn Pharmatech Co.,Ltd

Tel: 0931-4190454 13893344397
Fax: +86-931-8506154
Email: sales@kyxpharma.com
Country: China
ProdList: 310
Advantage: 55

Shanghai Keepontech Co.,Ltd

Tel: 021-54849683 13601642561
Fax: +86-21-54375689
Email: sales@keepontech.com
Country: China
ProdList: 998
Advantage: 59

Aloespharm Co., Ltd.

Tel: 021-20960837
Fax: 021-20960837
Email: market@aloespharm.com
Country: China
ProdList: 1302
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Nantong Bosu Pharmaceutical Technology Co., Ltd.

Tel: 0513-0513-51005092 13390947892
Fax: 0513-51005092
Email: tashiyxy@163.com
Country: China
ProdList: 839
Advantage: 58

NovoChemy Ltd.

Tel: 86-(0)21-31261262 373522135
Fax: 86-(0)21-33250524
Email: sales@novochemy.com
Country: China
ProdList: 6498
Advantage: 58

Yancheng Schiemann Biological Technology Co.,Ltd

Tel: 515-88280676 18921872653
Email: sales@ximanbio.com
Country: China
ProdList: 1524
Advantage: 56

Shanghai Chenzhu Pharmaceutical Co., Ltd.

Tel: 13162380607
Fax: QQ:1696175688
Email: 1696175688@qq.com
Country: China
ProdList: 817
Advantage: 55

112342-72-0, 2-AMINO-6-BROMOTHIAZOLO[4,5-B]PYRAZINERelated Search:

(6-aminopyridin-2-yl)methanol 6-Methoxypyrazinamine 6-FLUOROQUINOLIN-2-AMINE 2-Amino-6-Iodobenzothiazole 6-BROMOBENZOXAZOLE ethyl 2-amino-6-chloroisonicotinate 2-amino-6-chloropyridine-4-carboxylic acid 2-Amino-6-chloro-3-pyridinecarboxaldehyde 2-Amino-6-trifluoromethylquinoxaline 2-AMINO-6-BROMOPYRIDO[2,3-D]PYRIMIDIN-4(3H)-ONE 2-Amino-benzothiazole-6-carbonitrile 2-Amino-6-methylpyrazine 2-Amino-5-chloropyridine-3-carboxylic acid ETHYL 2-AMINO-6-CHLOROBENZOATE 2-Amino-6-bromo-pyridine-3-carbaldehyde 6-bromo-3-methoxypyridin-2-amine 2-AMINO-6-BROMO-1,8-NAPHTHYRIDINE 2-AMINO-6-BROMOTHIAZOLO[4,5-B]PYRAZINE

2-AMINO-6-BROMOTHIAZOLO[4,5-B]PYRAZINE

Thiazolo[4,5-b]pyrazin-2-amine, 6-bromo-

112342-72-0