(5-CHLOROPYRAZIN-2-YL)METHANOL
- Product Name
- (5-CHLOROPYRAZIN-2-YL)METHANOL
- CAS No.
- 72788-94-4
- Chemical Name
- (5-CHLOROPYRAZIN-2-YL)METHANOL
- Synonyms
- C90112;5-Chloro-2-pyrazineMethanol;5-Chloro-2-pyrazineMethan...;2-Pyrazinemethanol, 5-chloro-;(5-CHLOROPYRAZIN-2-YL)METHANOL;(5-Chloro-2-pyrazinyl)methanol;2-Chloro-5-(hydroxyMethyl)pyrazine;2-Hydroxymethyl-5-chloropyrazine 98%;2-HydroxyMethyl-5-chloropyrazine/(5-chloropyrazin-2-yl)Methanol
- CBNumber
- CB72456037
- Molecular Formula
- C5H5ClN2O
- Formula Weight
- 144.56
- MOL File
- 72788-94-4.mol
(5-CHLOROPYRAZIN-2-YL)METHANOL Property
- Melting point:
- 62-63 °C
- Boiling point:
- 255.7±35.0 °C(Predicted)
- Density
- 1.422±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 12.39±0.10(Predicted)
- Appearance
- Off-white to light yellow Solid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H413May cause long lasting harmful effects to aquatic life
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C381815
- Product name
- (5-Chloropyrazin-2-yl)methanol
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- W8125
- Product name
- (5-Chloropyrazin-2-yl)methanol
- Packaging
- 250mg
- Price
- $78
- Updated
- 2021/12/16
- Product number
- FC143804
- Product name
- (5-Chloropyrazin-2-yl)methanol
- Packaging
- 500mg
- Price
- $85
- Updated
- 2021/12/16
- Product number
- 4H01-5-62
- Product name
- 2-Hydroxymethyl-5-chloropyrazine
- Packaging
- 250mg
- Price
- $125
- Updated
- 2021/12/16
- Product number
- FC143804
- Product name
- (5-Chloropyrazin-2-yl)methanol
- Packaging
- 1g
- Price
- $151
- Updated
- 2021/12/16
(5-CHLOROPYRAZIN-2-YL)METHANOL Chemical Properties,Usage,Production
Synthesis
33332-25-1
72788-94-4
1. Methylation reaction: 5-chloropyrazine-2-carboxylic acid (3.21 g, 20.3 mmol) was dissolved in a solvent mixture of ether (20 mL) and methanol (20.0 mL), and 2M trimethylsilyl diazomethane ether solution (20.3 mL, 40.5 mmol) was added slowly. Intense bulging was observed at the beginning of the reaction, and the completion of the reaction was confirmed by LCMS analysis after 30 min. The reaction mixture was concentrated to give methyl 5-chloropyrazine-2-carboxylate (3.53 g, 20.5 mmol, 101% yield) as a tan solid.NMR analysis showed that the product was >95% pure and could be used directly in the next step of the reaction.1H NMR (400 MHz, CDCl3) δ (ppm): 9.09 (s, 1H), 8.70 (s, 1H), 4.04 (s, 3H). 4.04 (s, 3H). 2. 2. Reduction reaction: To a solution of methyl 5-chloropyrazine-2-carboxylate (3.50 g, 20.3 mmol) in tetrahydrofuran (101 mL) was added dropwise 1M diisobutylaluminum hydride in tetrahydrofuran (42.6 mL, 42.6 mmol) at 0 °C. The reaction was stirred for 2 hours. The reaction was stirred at 0 °C for 2 h and then quenched by the addition of methanol (2 mL). Subsequently, saturated potassium sodium tartrate solution was added and the reaction mixture was extracted with ethyl acetate (3 x 100 mL), the organic phase was dried over anhydrous sodium sulfate, filtered and concentrated to give a brown residue. Purification by silica gel column chromatography (Luknova 120 g, 20 mL/min) with an elution gradient of 30 to 100% ethyl acetate in hexane solution over 60 min gave (5-chloropyrazin-2-yl)methanol (1.45 g, 10.0 mmol, 50% yield) as a tan solid.1H NMR (400 MHz, CDCl3) δ (ppm): 8.56 (s, 1H NMR): 8.56 (s, 1H NMR). ): 8.56 (s, 1H), 8.45 (s, 1H), 4.84 (s, 2H), 2.79 (br.s, 1H). 3. Methylsulfonylation: To a solution of (5-chloropyrazin-2-yl)methanol (648 mg, 4.48 mmol) in dichloromethane (12 mL) was added triethylamine (1.87 mL, 13.5 mmol) followed by dropwise addition of methanesulfonyl chloride (0.699 mL, 8.97 mmol) at 0 °C. After 20 min, LCMS analysis showed the reaction was completely converted to the methanesulfonate product. The reaction mixture was concentrated to afford (5-chloropyrazin-2-yl) methyl methanesulfonate (787 mg, 3.53 mmol, 79% yield) as an oil, which could be used in subsequent steps without further purification.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 23, p. 5674 - 5678
[2] Patent: WO2012/88469, 2012, A1. Location in patent: Page/Page column 151-152
[3] Patent: WO2018/93569, 2018, A1. Location in patent: Page/Page column 195; 196
[4] Patent: WO2008/130320, 2008, A2. Location in patent: Page/Page column 151
[5] Patent: WO2012/81736, 2012, A1. Location in patent: Page/Page column 44
(5-CHLOROPYRAZIN-2-YL)METHANOL Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (5-CHLOROPYRAZIN-2-YL)METHANOL manufacturers
- Product
- (5-CHLOROPYRAZIN-2-YL)METHANOL 72788-94-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2019-12-30