5-(2-PYRIDYL)-1,2-DIHYDROPYRIDIN-2-ONE

Product Name: 5-(2-PYRIDYL)-1,2-DIHYDROPYRIDIN-2-ONE
CAS No.: 381233-78-9
Chemical Name: 5-(2-PYRIDYL)-1,2-DIHYDROPYRIDIN-2-ONE
Synonyms: [2,3'-BIPYRIDIN]-6'(1'H)-ONE;3'-bipyridin]-6'-ol;Perampanel Impurity 1;2,3'-bipyridin]-6'-ol;Pyronoprene Impurity 47;5-(2-PYRIDYL)-2-PYRIDONE;Perampanel Intermediate 1;2,3'-Bipyridin]-6'(1'H)-one;5-(2-Pyridyl)pyridin-2(1H)-one;2-Hydroxy-5-(2-pyridyl)pyridine
CBNumber: CB72456451
Molecular Formula: C10H8N2O
Formula Weight: 172.18
MOL File: 381233-78-9.mol

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5-(2-PYRIDYL)-1,2-DIHYDROPYRIDIN-2-ONE Property

Melting point:: 71-75°C
Boiling point:: 434.3±45.0 °C(Predicted)
Density: 1.221±0.06 g/cm3 (20 ºC 760 Torr)
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka: 10.85±0.10(Predicted)
form: Solid
color: White
InChI: InChI=1S/C10H8N2O/c13-10-5-4-8(7-12-10)9-3-1-2-6-11-9/h1-7H,(H,12,13)
InChIKey: NHWKTZWOSIVHOL-UHFFFAOYSA-N
SMILES: C1(C2C=CC(=O)NC=2)=NC=CC=C1

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Safety

HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: P991805
Product name: 5-(2-Pyridyl)-1,2-dihydropyridin-2-one
Packaging: 1g
Price: $180
Updated: 2021/12/16

TRC

Product number: P991805
Product name: 5-(2-Pyridyl)-1,2-dihydropyridin-2-one
Packaging: 2.5g
Price: $325
Updated: 2021/12/16

AK Scientific

Product number: 4908AB
Product name: [2,3'-Bipyridin]-6'(1'H)-one
Packaging: 1g
Price: $188
Updated: 2021/12/16

Matrix Scientific

Product number: 089188
Product name: 5-(Pyridin-2-yl)-1,2-dihydropyridin-2-one
Purity: >97%
Packaging: 500mg
Price: $408
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0387658
Product name: [2,3'-BIPYRIDIN]-6'(1'-H)-ONE
Purity: 95.00%
Packaging: 5MG
Price: $498.76
Updated: 2021/12/16

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5-(2-PYRIDYL)-1,2-DIHYDROPYRIDIN-2-ONE Chemical Properties,Usage,Production

Uses

5-(2-Pyridyl)-1,2-dihydropyridin-2-one is used in the synthesis of AMPA receptor antagonists in the treatment of neurological diseases causing dysfunction of glutamatergic neurotransmission.

Synthesis

109-04-6

1054483-78-1

381233-78-9

The general procedure for the synthesis of [2,3'-bipyridin]-6'(1'H)-ones from 2-bromopyridine and 2-hydroxypyridine-5-boronic acid pinacol ester was carried out as follows: firstly, the synthesis of [2,3'-bipyridin]-6'(1'H)-one was carried out by Suzuki coupling reaction of 2-bromopyridine (18) with 6-hydroxypyridine-3-boronic acid pinacol ester catalyzed by Pd(PPh3)4, with Na2CO3 as the base and CH3CN/H2O ( 1/1) as solvent and reacted at 75 °C to afford intermediate 20 in 70% yield. Subsequently, intermediate 20 was converted to thio analog 21 in 71% yield by reaction with P2S5 in pyridine at 120 °C. Finally, intermediate 21 was alkylated with 2-methylbenzyl bromide in DMF in the presence of K2CO3 to give the target product 22 in 76% yield. This synthetic route is also suitable for the preparation of other analogs for assessing the effect of phenyl and pyridyl substituents on the pyridazine ring.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 19, p. 5774 - 5777
[2] Patent: WO2013/19938, 2013, A1. Location in patent: Page/Page column 34; 35

5-(2-PYRIDYL)-1,2-DIHYDROPYRIDIN-2-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-(2-PYRIDYL)-1,2-DIHYDROPYRIDIN-2-ONE Suppliers

China 170 India 8 United Kingdom 2 United States 5 Global 185

Sichuan Lancent Medical Devices Co., Ltd.

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View Lastest Price from 5-(2-PYRIDYL)-1,2-DIHYDROPYRIDIN-2-ONE manufacturers

Shanghai Joiny Pharmaceutical Co.,LTD

Product: 5-(2-Pyridyl)-1,2-dihydropyridin-2-one 381233-78-9
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 25kg
Release date: 2022-02-17

Henan Fengda Chemical Co., Ltd

Product: 5-(2-PYRIDYL)-1,2-DIHYDROPYRIDIN-2-ONE 381233-78-9
Price: US $8.00-2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-24

Hangzhou ICH Biofarm Co., Ltd

Product: 5-(2-PYRIDYL)-1,2-DIHYDROPYRIDIN-2-ONE 381233-78-9
Price: US $0.00-0.00/kg
Min. Order: 0.1kg
Purity: 99.0%min
Supply Ability: 200kg
Release date: 2023-06-09

381233-78-9, 5-(2-PYRIDYL)-1,2-DIHYDROPYRIDIN-2-ONERelated Search:

4-HYDROXYPYRIDINE 5'-broMo-1'-phenyl-[2,3'-bipyridin]-6'(1'H)-one 2-(1,3,2-DIOXABOROLAN-2-YL)BENZONITRILE 5-Bromo-2-methoxypyridine 2,5-Dibromopyridine 2-(2-cyanophenyl)benzonitrile 2-Bromobenzonitrile 1-Phenyl-5-(pyridin-2-yl)-1,2-dihydropyridin-2-one 3,5-Dimethoxypyridine Phenylboronic acid 2-Cyanophenylboronic acid PeraMpanel 3,5-Dibromopyridine 6'-Methoxy-2,3'-bipyridine PeraMpanel PRMWGUBFXWROHD-MYWHSQMISA-N 5'-(2-cyanophenyl)-6'-oxo-1'-phenyl-1',6'-dihydro-[2,3'-bipyridine] 1-oxide 4-(6'-oxo-1'-phenyl-1',6'-dihydro-[2,3'-bipyridin]-5'-yl)benzonitrile

[2,3'-BIPYRIDIN]-6'(1'H)-ONE

5-(2-PYRIDYL)-1,2-DIHYDROPYRIDIN-2-ONE

5-(Pyridin-2-yl)-2(1H)-pyridone

5-(Pyridin-2-yl)-1,2-dihydropyridin-2-one

5-(Pyridin-2-yl)pyridin-2(1H)-one

5-(2-Pyridyl)pyridin-2(1H)-one

5-pyridin-2-yl-1H-pyridin-2-one

5-(2-PYRIDYL)-2-PYRIDONE

2-Hydroxy-5-(2-pyridyl)pyridine

5-(2-pyridyl)-1,2-dihydropyridine-2-one

Perampanel Impurity 1

3'-bipyridin]-6'-ol

2,3'-bipyridin]-6'-ol

Perampanel Intermediate 1

2,3'-Bipyridin]-6'(1'H)-one (9CI, ACI)

2,3'-Bipyridin]-6'(1'H)-one

Pyronoprene Impurity 47

381233-78-9

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