PIPERLONGUMINE

Product Name: PIPERLONGUMINE
CAS No.: 20069-09-4
Chemical Name: PIPERLONGUMINE
Synonyms: ong;PPLGM;umine;PiperL;ongumine;acryloyl);Piplartin;PIPLARTINE;PIPERLONGUMIN;Piperlorgumia
CBNumber: CB7246450
Molecular Formula: C17H19NO5
Formula Weight: 317.34
MOL File: 20069-09-4.mol

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PIPERLONGUMINE Property

Melting point:: 124°C
Boiling point:: 475.6±45.0 °C(Predicted)
Density: 1.223±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: ≥5mg/mL at warmed to 60°C
form: powder
pka: -1.88±0.20(Predicted)
color: white to beige
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
LogP: 2.340 (est)

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Safety

WGK Germany: 3
RTECS: UU7785850
HS Code: 2932209090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H320Causes eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0221
Product name: Piperlongumine
Purity: ≥97% (HPLC)
Packaging: 5mg
Price: $77.4
Updated: 2024/03/01

Sigma-Aldrich

Product number: 528124
Product name: Piperlongumine
Packaging: 25mg
Price: $85.2
Updated: 2024/03/01

TCI Chemical

Product number: P2361
Product name: Piperlongumine
Purity: >97.0%(HPLC)
Packaging: 25mg
Price: $98
Updated: 2024/03/01

TCI Chemical

Product number: P2361
Product name: Piperlongumine
Purity: >97.0%(HPLC)
Packaging: 100mg
Price: $313
Updated: 2021/12/16

Cayman Chemical

Product number: 11006
Product name: Piperlongumine
Purity: ≥98%
Packaging: 25mg
Price: $44
Updated: 2024/03/01

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PIPERLONGUMINE Chemical Properties,Usage,Production

Description

A piperidinone alkaloid present in Piper longum, the structure has been shown to be N-(3:4:5-trimethoxycinnamoyl)-Lls-piperidin-2-one. In the plant, the base occurs mainly in the roots.

Uses

Piperlongumine has been used to study the regulation of protein regulator of cytokinesis 1 (PRC1) expression. It has also been used to investigate its anti-tumor effects on human melanoma cells in vitro.

Uses

anti-asthma, antibronchitis

Uses

Piperlongumine (PL), a new alkaloid abundantly present in Piper longum fruits strongly inhibited platelet cell aggregation. It may have anti-cancer properties. It selectively targets and kills cancer cells but leaving normal cells unharmed.

Definition

ChEBI: Piplartine is a member of cinnamamides and a dicarboximide.

General Description

Piperlongumine is an alkaloid, which is extracted from Piper longum Linn. It exhibits anti-atherosclerotic, anxiolytic, antidiabetic, antidepressant, antibacterial, anti-platelet, aggregation, anxiolytic and anti-inflammatory properties. Piperlongumine prevents the production of tumor necrosis factor-α and interleukin-6. It blocks the activation of nuclear factor-κB (NF-κB) against proinflammatory responses. Piperlongumine inhibits plaque formation and inhibits vascular smooth muscle cell migration. It is used to treat cough, respiratory infections and stomach-ache.

Biochem/physiol Actions

Piperlongumine selectively kills cancer cells regardless of p53 status without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1). It increases the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells with little effect on either rapidly or slowly dividing primary normal cells. Piperlongumine showed significant antitumour effects in a variety of mouse tumour models and inhibited growth of spontaneously formed malignant breast tumours and their associated metastases.

target

P450 (e.g. CYP17) | Antifection

References

Chatterjee, Dutta., Tetrahedron, 23, 1769 (1967)

PIPERLONGUMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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PIPERLONGUMINE Suppliers

Canada 3 China 187 Germany 2 India 8 Japan 1 Switzerland 1 United Kingdom 8 United States 22 Global 232

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View Lastest Price from PIPERLONGUMINE manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd

Product: PIPERLONGUMINE 20069-09-4
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: 5000
Release date: 2024-12-11

Wuhan Nutra Biotechnology Co.,Ltd

Product: Piplartine powder ;Piperlongumine 20069-09-4
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 100kgs
Release date: 2021-05-23

Hebei Weibang Biotechnology Co., Ltd

Product: PIPERLONGUMINE 20069-09-4
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100 mt
Release date: 2024-10-29

20069-09-4, PIPERLONGUMINERelated Search:

Daurinoline 2-[2-(Methylamino)benzoyl]-3,4-dihydro-β-carboline-1(2H)-one VERATRIDINE Xanthiside menisdaurin 5-PROPENYL-1,2,3-TRIMETHOXY N,N-DIETHYLACRYLAMIDE Cintramide PIPERLONGUMINE N-ALLYLACRYLAMIDE SINAPINALDEHYDE 1-METHYL-1,2,3,6-TETRAHYDROPYRIDINE CHEMBRDG-BB 9070763 CHEMBRDG-BB 9071121 4-HYDROXY-3-METHOXYCINNAMIDE PIPERLONGUMINE(RG) CINNAMAMIDE, N-ALLYL-, (E)- 3,4,5-TRIMETHOXYCINNAMALDEHYDE

PIPERLONGUMIN

PIPERLONGUMINE

PIPLARTINE

5,6-DIHYDRO-1-[1-OXO-3-3,4,5-TRIMETHOXYPHENYL-TRANS-2-PROPENYL]-21H-PYRIDINONE

piperlongumine from long pepper

(E)-1-(3-(3,4,5-trimethoxyphenyl)acryloyl)-5,6-dihydropyridin-2(1H)-one

PPLGM

1-[(E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]-2,3-dihydropyridin-6-one

-1-(3-(3,4,5-Trimethoxyphenyl)

-5,6-dihydropyridin-2(1H)

acryloyl)

5,6-Dihydro-1-[1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propenyl]pyridin-2(1H)-one

(E)-1-(3-(3,4,5-TRIMETHOXYPHENYL)ACRYLOYL)PIPERIDIN-2-ONE

5,6-dihydro-1-[1-oxo-3-(3,4,5-triMethoxyphenyl)-allyl]-2(1H)-pyridinone

(E)-5,6-Dihydro-1-[1-oxo-3-(3,4,5-triMethoxyphenyl)-2-propenyl]-2(1H)-pyridinone

5,6-Dihydro-1-(3,4,5-triMethoxycinnaMoyl)-2(1H)-pyridone

5,6-Dihydro-1-[(2E)-1-oxo-3-(3,4,5-triMethoxyphenyl)-2-propen-1-yl]-2(1H)-pyridinone

Piplartin

PIPERLONGUMINE(P)

Piperlongumine - Piplartine

Piperlongumine - CAS 20069-09-4 - Calbiochem

ong

PiperL

umine

Piperlangamine

2(1H)-Pyridinone, 5,6-dihydro-1-[(2E)-1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propen-1-yl]-

ongumine

Piplartine powder

Piperlorgumine (natural )

Piperlorgumia

PIPERLONGUMINE98%

Piperlongumine, alkaloid from Piper longum L.

20069-09-4

20069-09-0

C17H19NO5

Building Blocks

C9 to C46

Heterocyclic Building Blocks

Pyridines

Aromatics

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals