ChemicalBook > CAS DataBase List > (E)-TERT-BUTYL 3-((DIMETHYLAMINO)METHYLENE)-4-OXOPYRROLIDINE-1-CARBOXYLATE

(E)-TERT-BUTYL 3-((DIMETHYLAMINO)METHYLENE)-4-OXOPYRROLIDINE-1-CARBOXYLATE

Product Name
(E)-TERT-BUTYL 3-((DIMETHYLAMINO)METHYLENE)-4-OXOPYRROLIDINE-1-CARBOXYLATE
CAS No.
157327-42-9
Chemical Name
(E)-TERT-BUTYL 3-((DIMETHYLAMINO)METHYLENE)-4-OXOPYRROLIDINE-1-CARBOXYLATE
Synonyms
tert-Butyl 3-((dimethylamino)methylene)-4-oxo...;1-Boc-3-((dimethylamino)methylene)-4-oxopyrrolidine;3-((dimethylamino)methylene)-4-oxopyrrolidine-1-carboxylate;tert-butyl 3-((dimethylamino)methylene)-4-oxopyrrolidine-1-c...;tert-Butyl 3-((diMethylaMino)Methylene)-4-oxopyrrolidine-1-carboxylate;(E)-TERT-BUTYL 3-((DIMETHYLAMINO)METHYLENE)-4-OXOPYRROLIDINE-1-CARBOXYLATE;tert-butyl (Z)-3-((dimethylamino)methylene)-4-oxopyrrolidine-1-carboxylate;3-DiMethylaMinoMethylene-4-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester;3-(diMethylaMinoMethylidene)-4-oxo-1-pyrrolidinecarboxylic acid tert-butyl ester;1-Pyrrolidinecarboxylic acid, 3-[(dimethylamino)methylene]-4-oxo-, 1,1-dimethylethyl ester
CBNumber
CB72465563
Molecular Formula
C12H20N2O3
Formula Weight
240.3
MOL File
157327-42-9.mol
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(E)-TERT-BUTYL 3-((DIMETHYLAMINO)METHYLENE)-4-OXOPYRROLIDINE-1-CARBOXYLATE Property

Boiling point:
341.0±42.0 °C(Predicted)
Density 
1.175±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
5.25±0.20(Predicted)
Appearance
Light yellow to yellow Solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Biosynth Carbosynth
Product number
FB154418
Product name
tert-Butyl3-((dimethylamino)methylene)-4-oxopyrrolidine-1-carboxylate
Packaging
500mg
Price
$55
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB154418
Product name
tert-Butyl3-((dimethylamino)methylene)-4-oxopyrrolidine-1-carboxylate
Packaging
1g
Price
$99
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB154418
Product name
tert-Butyl3-((dimethylamino)methylene)-4-oxopyrrolidine-1-carboxylate
Packaging
2g
Price
$172
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB154418
Product name
tert-Butyl3-((dimethylamino)methylene)-4-oxopyrrolidine-1-carboxylate
Packaging
5G
Price
$344
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0394047
Product name
TERT-BUTYL-3-((DIMETHYLAMINO)METHYLENE)-4-OXOPYRROLIDINE-1-CARBOXYLATE
Purity
95.00%
Packaging
5MG
Price
$496.56
Updated
2021/12/16
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(E)-TERT-BUTYL 3-((DIMETHYLAMINO)METHYLENE)-4-OXOPYRROLIDINE-1-CARBOXYLATE Chemical Properties,Usage,Production

Synthesis

4637-24-5

101385-93-7

157327-42-9

Step 1: Synthesis of tert-butyl 3-((dimethylamino)methylene)-4-oxopyrrolidine-1-carboxylate. 1-tert-butoxycarbonyl-3-pyrrolidinone (10 g, 54.05 mmol) was suspended in N,N-dimethylformamide dimethyl acetal (120 mL) and the reaction was stirred at 105 °C for 1 hour. Upon completion of the reaction, the reaction mixture was cooled to 0 °C. Subsequently, the solvent was removed by distillation under reduced pressure at room temperature. The residue was purified by silica gel column chromatography (eluent: dichloromethane/methanol = 60/1 to 20/1) to afford the target product tert-butyl 3-((dimethylamino)methylene)-4-oxopyrrolidine-1-carboxylate (10.78 g, 83% yield). The product was analyzed by ESI-LCMS showing m/z: 241.2 [M+1]+; 1H NMR (400 MHz, CDCl3) δppm: 7.26 (s, 1H), 4.57 (s, 2H), 3.86 (s, 2H), 3.09 (s, 6H), 1.48 (s, 9H).

References

[1] Patent: WO2016/44641, 2016, A2. Location in patent: Paragraph 00377
[2] Heterocycles, 2002, vol. 56, # 1-2, p. 257 - 264
[3] Patent: US2013/237538, 2013, A1. Location in patent: Paragraph 0308
[4] Patent: US2013/237537, 2013, A1. Location in patent: Paragraph 0292-0293
[5] Patent: WO2007/97931, 2007, A2. Location in patent: Page/Page column 32

(E)-TERT-BUTYL 3-((DIMETHYLAMINO)METHYLENE)-4-OXOPYRROLIDINE-1-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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(E)-TERT-BUTYL 3-((DIMETHYLAMINO)METHYLENE)-4-OXOPYRROLIDINE-1-CARBOXYLATE Suppliers

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View Lastest Price from (E)-TERT-BUTYL 3-((DIMETHYLAMINO)METHYLENE)-4-OXOPYRROLIDINE-1-CARBOXYLATE manufacturers

Nanjing Fred Technology Co., Ltd
Product
(E)-tert-butyl 3-((dimethylamino)methylene)-4-oxopyrrolidine-1-carboxylate 157327-42-9
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1 ton
Release date
2024-01-02
Career Henan Chemical Co
Product
(E)-TERT-BUTYL 3-((DIMETHYLAMINO)METHYLENE)-4-OXOPYRROLIDINE-1-CARBOXYLATE 157327-42-9
Price
US $1.00/KG
Min. Order
1KG
Purity
98% HPLC
Supply Ability
10 tons/month
Release date
2020-01-08

157327-42-9, (E)-TERT-BUTYL 3-((DIMETHYLAMINO)METHYLENE)-4-OXOPYRROLIDINE-1-CARBOXYLATERelated Search:


  • (E)-TERT-BUTYL 3-((DIMETHYLAMINO)METHYLENE)-4-OXOPYRROLIDINE-1-CARBOXYLATE
  • 3-(diMethylaMinoMethylidene)-4-oxo-1-pyrrolidinecarboxylic acid tert-butyl ester
  • 3-DiMethylaMinoMethylene-4-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester
  • tert-Butyl 3-((diMethylaMino)Methylene)-4-oxopyrrolidine-1-carboxylate
  • 3-((dimethylamino)methylene)-4-oxopyrrolidine-1-carboxylate
  • tert-butyl (Z)-3-((dimethylamino)methylene)-4-oxopyrrolidine-1-carboxylate
  • tert-Butyl 3-((dimethylamino)methylene)-4-oxo...
  • 1-Pyrrolidinecarboxylic acid, 3-[(dimethylamino)methylene]-4-oxo-, 1,1-dimethylethyl ester
  • tert-butyl 3-((dimethylamino)methylene)-4-oxopyrrolidine-1-c...
  • 1-Boc-3-((dimethylamino)methylene)-4-oxopyrrolidine
  • 157327-42-9