(E)-TERT-BUTYL 3-((DIMETHYLAMINO)METHYLENE)-4-OXOPYRROLIDINE-1-CARBOXYLATE

Product Name: (E)-TERT-BUTYL 3-((DIMETHYLAMINO)METHYLENE)-4-OXOPYRROLIDINE-1-CARBOXYLATE
CAS No.: 157327-42-9
Chemical Name: (E)-TERT-BUTYL 3-((DIMETHYLAMINO)METHYLENE)-4-OXOPYRROLIDINE-1-CARBOXYLATE
Synonyms: tert-Butyl 3-((dimethylamino)methylene)-4-oxo...;1-Boc-3-((dimethylamino)methylene)-4-oxopyrrolidine;3-((dimethylamino)methylene)-4-oxopyrrolidine-1-carboxylate;tert-butyl 3-((dimethylamino)methylene)-4-oxopyrrolidine-1-c...;tert-Butyl 3-((diMethylaMino)Methylene)-4-oxopyrrolidine-1-carboxylate;(E)-TERT-BUTYL 3-((DIMETHYLAMINO)METHYLENE)-4-OXOPYRROLIDINE-1-CARBOXYLATE;tert-butyl (Z)-3-((dimethylamino)methylene)-4-oxopyrrolidine-1-carboxylate;3-DiMethylaMinoMethylene-4-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester;3-(diMethylaMinoMethylidene)-4-oxo-1-pyrrolidinecarboxylic acid tert-butyl ester;1-Pyrrolidinecarboxylic acid, 3-[(dimethylamino)methylene]-4-oxo-, 1,1-dimethylethyl ester
CBNumber: CB72465563
Molecular Formula: C12H20N2O3
Formula Weight: 240.3
MOL File: 157327-42-9.mol

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(E)-TERT-BUTYL 3-((DIMETHYLAMINO)METHYLENE)-4-OXOPYRROLIDINE-1-CARBOXYLATE Property

Boiling point:: 341.0±42.0 °C(Predicted)
Density: 1.175±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 5.25±0.20(Predicted)
Appearance: Light yellow to yellow Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FB154418
Product name: tert-Butyl3-((dimethylamino)methylene)-4-oxopyrrolidine-1-carboxylate
Packaging: 500mg
Price: $55
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB154418
Product name: tert-Butyl3-((dimethylamino)methylene)-4-oxopyrrolidine-1-carboxylate
Packaging: 1g
Price: $99
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB154418
Product name: tert-Butyl3-((dimethylamino)methylene)-4-oxopyrrolidine-1-carboxylate
Packaging: 2g
Price: $172
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB154418
Product name: tert-Butyl3-((dimethylamino)methylene)-4-oxopyrrolidine-1-carboxylate
Packaging: 5G
Price: $344
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0394047
Product name: TERT-BUTYL-3-((DIMETHYLAMINO)METHYLENE)-4-OXOPYRROLIDINE-1-CARBOXYLATE
Purity: 95.00%
Packaging: 5MG
Price: $496.56
Updated: 2021/12/16

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(E)-TERT-BUTYL 3-((DIMETHYLAMINO)METHYLENE)-4-OXOPYRROLIDINE-1-CARBOXYLATE Chemical Properties,Usage,Production

Synthesis

4637-24-5

101385-93-7

157327-42-9

Step 1: Synthesis of tert-butyl 3-((dimethylamino)methylene)-4-oxopyrrolidine-1-carboxylate. 1-tert-butoxycarbonyl-3-pyrrolidinone (10 g, 54.05 mmol) was suspended in N,N-dimethylformamide dimethyl acetal (120 mL) and the reaction was stirred at 105 °C for 1 hour. Upon completion of the reaction, the reaction mixture was cooled to 0 °C. Subsequently, the solvent was removed by distillation under reduced pressure at room temperature. The residue was purified by silica gel column chromatography (eluent: dichloromethane/methanol = 60/1 to 20/1) to afford the target product tert-butyl 3-((dimethylamino)methylene)-4-oxopyrrolidine-1-carboxylate (10.78 g, 83% yield). The product was analyzed by ESI-LCMS showing m/z: 241.2 [M+1]+; 1H NMR (400 MHz, CDCl3) δppm: 7.26 (s, 1H), 4.57 (s, 2H), 3.86 (s, 2H), 3.09 (s, 6H), 1.48 (s, 9H).

References

[1] Patent: WO2016/44641, 2016, A2. Location in patent: Paragraph 00377
[2] Heterocycles, 2002, vol. 56, # 1-2, p. 257 - 264
[3] Patent: US2013/237538, 2013, A1. Location in patent: Paragraph 0308
[4] Patent: US2013/237537, 2013, A1. Location in patent: Paragraph 0292-0293
[5] Patent: WO2007/97931, 2007, A2. Location in patent: Page/Page column 32

(E)-TERT-BUTYL 3-((DIMETHYLAMINO)METHYLENE)-4-OXOPYRROLIDINE-1-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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(E)-TERT-BUTYL 3-((DIMETHYLAMINO)METHYLENE)-4-OXOPYRROLIDINE-1-CARBOXYLATE Suppliers

China 57 Germany 1 India 1 United Kingdom 1 United States 3 Global 63

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View Lastest Price from (E)-TERT-BUTYL 3-((DIMETHYLAMINO)METHYLENE)-4-OXOPYRROLIDINE-1-CARBOXYLATE manufacturers

Nanjing Fred Technology Co., Ltd

Product: (E)-tert-butyl 3-((dimethylamino)methylene)-4-oxopyrrolidine-1-carboxylate 157327-42-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1 ton
Release date: 2024-01-02

Career Henan Chemical Co

Product: (E)-TERT-BUTYL 3-((DIMETHYLAMINO)METHYLENE)-4-OXOPYRROLIDINE-1-CARBOXYLATE 157327-42-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98% HPLC
Supply Ability: 10 tons/month
Release date: 2020-01-08

157327-42-9, (E)-TERT-BUTYL 3-((DIMETHYLAMINO)METHYLENE)-4-OXOPYRROLIDINE-1-CARBOXYLATERelated Search:

(E)-TERT-BUTYL 3-((DIMETHYLAMINO)METHYLENE)-4-OXOPYRROLIDINE-1-CARBOXYLATE

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157327-42-9