(E)-TERT-BUTYL 3-((DIMETHYLAMINO)METHYLENE)-4-OXOPYRROLIDINE-1-CARBOXYLATE
- Product Name
- (E)-TERT-BUTYL 3-((DIMETHYLAMINO)METHYLENE)-4-OXOPYRROLIDINE-1-CARBOXYLATE
- CAS No.
- 157327-42-9
- Chemical Name
- (E)-TERT-BUTYL 3-((DIMETHYLAMINO)METHYLENE)-4-OXOPYRROLIDINE-1-CARBOXYLATE
- Synonyms
- tert-Butyl 3-((dimethylamino)methylene)-4-oxo...;1-Boc-3-((dimethylamino)methylene)-4-oxopyrrolidine;3-((dimethylamino)methylene)-4-oxopyrrolidine-1-carboxylate;tert-butyl 3-((dimethylamino)methylene)-4-oxopyrrolidine-1-c...;tert-Butyl 3-((diMethylaMino)Methylene)-4-oxopyrrolidine-1-carboxylate;(E)-TERT-BUTYL 3-((DIMETHYLAMINO)METHYLENE)-4-OXOPYRROLIDINE-1-CARBOXYLATE;tert-butyl (Z)-3-((dimethylamino)methylene)-4-oxopyrrolidine-1-carboxylate;3-DiMethylaMinoMethylene-4-oxo-pyrrolidine-1-carboxylic acid tert-butyl ester;3-(diMethylaMinoMethylidene)-4-oxo-1-pyrrolidinecarboxylic acid tert-butyl ester;1-Pyrrolidinecarboxylic acid, 3-[(dimethylamino)methylene]-4-oxo-, 1,1-dimethylethyl ester
- CBNumber
- CB72465563
- Molecular Formula
- C12H20N2O3
- Formula Weight
- 240.3
- MOL File
- 157327-42-9.mol
(E)-TERT-BUTYL 3-((DIMETHYLAMINO)METHYLENE)-4-OXOPYRROLIDINE-1-CARBOXYLATE Property
- Boiling point:
- 341.0±42.0 °C(Predicted)
- Density
- 1.175±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 5.25±0.20(Predicted)
- Appearance
- Light yellow to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- FB154418
- Product name
- tert-Butyl3-((dimethylamino)methylene)-4-oxopyrrolidine-1-carboxylate
- Packaging
- 500mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- FB154418
- Product name
- tert-Butyl3-((dimethylamino)methylene)-4-oxopyrrolidine-1-carboxylate
- Packaging
- 1g
- Price
- $99
- Updated
- 2021/12/16
- Product number
- FB154418
- Product name
- tert-Butyl3-((dimethylamino)methylene)-4-oxopyrrolidine-1-carboxylate
- Packaging
- 2g
- Price
- $172
- Updated
- 2021/12/16
- Product number
- FB154418
- Product name
- tert-Butyl3-((dimethylamino)methylene)-4-oxopyrrolidine-1-carboxylate
- Packaging
- 5G
- Price
- $344
- Updated
- 2021/12/16
- Product number
- CHM0394047
- Product name
- TERT-BUTYL-3-((DIMETHYLAMINO)METHYLENE)-4-OXOPYRROLIDINE-1-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.56
- Updated
- 2021/12/16
(E)-TERT-BUTYL 3-((DIMETHYLAMINO)METHYLENE)-4-OXOPYRROLIDINE-1-CARBOXYLATE Chemical Properties,Usage,Production
Synthesis
4637-24-5
101385-93-7
157327-42-9
Step 1: Synthesis of tert-butyl 3-((dimethylamino)methylene)-4-oxopyrrolidine-1-carboxylate. 1-tert-butoxycarbonyl-3-pyrrolidinone (10 g, 54.05 mmol) was suspended in N,N-dimethylformamide dimethyl acetal (120 mL) and the reaction was stirred at 105 °C for 1 hour. Upon completion of the reaction, the reaction mixture was cooled to 0 °C. Subsequently, the solvent was removed by distillation under reduced pressure at room temperature. The residue was purified by silica gel column chromatography (eluent: dichloromethane/methanol = 60/1 to 20/1) to afford the target product tert-butyl 3-((dimethylamino)methylene)-4-oxopyrrolidine-1-carboxylate (10.78 g, 83% yield). The product was analyzed by ESI-LCMS showing m/z: 241.2 [M+1]+; 1H NMR (400 MHz, CDCl3) δppm: 7.26 (s, 1H), 4.57 (s, 2H), 3.86 (s, 2H), 3.09 (s, 6H), 1.48 (s, 9H).
References
[1] Patent: WO2016/44641, 2016, A2. Location in patent: Paragraph 00377
[2] Heterocycles, 2002, vol. 56, # 1-2, p. 257 - 264
[3] Patent: US2013/237538, 2013, A1. Location in patent: Paragraph 0308
[4] Patent: US2013/237537, 2013, A1. Location in patent: Paragraph 0292-0293
[5] Patent: WO2007/97931, 2007, A2. Location in patent: Page/Page column 32
(E)-TERT-BUTYL 3-((DIMETHYLAMINO)METHYLENE)-4-OXOPYRROLIDINE-1-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
(E)-TERT-BUTYL 3-((DIMETHYLAMINO)METHYLENE)-4-OXOPYRROLIDINE-1-CARBOXYLATE Suppliers
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- Fax
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- sales@ajchem.in
- Country
- India
- ProdList
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- Advantage
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View Lastest Price from (E)-TERT-BUTYL 3-((DIMETHYLAMINO)METHYLENE)-4-OXOPYRROLIDINE-1-CARBOXYLATE manufacturers
- Product
- (E)-tert-butyl 3-((dimethylamino)methylene)-4-oxopyrrolidine-1-carboxylate 157327-42-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1 ton
- Release date
- 2024-01-02
- Product
- (E)-TERT-BUTYL 3-((DIMETHYLAMINO)METHYLENE)-4-OXOPYRROLIDINE-1-CARBOXYLATE 157327-42-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98% HPLC
- Supply Ability
- 10 tons/month
- Release date
- 2020-01-08