Methyl 4-chloro-6-methylnicotinate
- Product Name
- Methyl 4-chloro-6-methylnicotinate
- CAS No.
- 53277-47-7
- Chemical Name
- Methyl 4-chloro-6-methylnicotinate
- Synonyms
- Methyl 4-chloro-6-methylnicotinate;Methyl 2-chloro-6-methylnicotinate;METHYL6-METHYL-2-CHLOROPYRIDINE-3-CARBOXYLATE;2-Chloro-6-methyl-3-pyridinecarboxylic acid methyl ester;3-Pyridinecarboxylic acid, 2-chloro-6-Methyl-, Methyl ester;Methyl 2-chloro-6-methylpyridine-3-carboxylate, 2-Chloro-3-(methoxycarbonyl)-6-methylpyridine
- CBNumber
- CB72470208
- Molecular Formula
- C8H8ClNO2
- Formula Weight
- 185.61
- MOL File
- 53277-47-7.mol
Methyl 4-chloro-6-methylnicotinate Property
- Melting point:
- 27-28℃
- Boiling point:
- 253℃
- Density
- 1.247
- Flash point:
- 107℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -0.43±0.10(Predicted)
- Appearance
- Colorless to off-white <27°C Solid,>28°C Liquid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- M340420
- Product name
- Methyl2-Chloro-6-methylnicotinate
- Packaging
- 500mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- 4H23-5-X7
- Product name
- Methyl 2-chloro-6-methylnicotinate
- Packaging
- 1g
- Price
- $87
- Updated
- 2021/12/16
- Product number
- 7556AB
- Product name
- Methyl2-chloro-6-methylnicotinate
- Packaging
- 1g
- Price
- $131
- Updated
- 2021/12/16
- Product number
- HCH0369186
- Product name
- METHYL-2-CHLORO-6-METHYLNICOTINATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.94
- Updated
- 2021/12/16
- Product number
- 7556AB
- Product name
- Methyl2-chloro-6-methylnicotinate
- Packaging
- 25g
- Price
- $797
- Updated
- 2021/12/16
Methyl 4-chloro-6-methylnicotinate Chemical Properties,Usage,Production
Synthesis
67-56-1
30529-70-5
53277-47-7
The general procedure for the synthesis of methyl 2-chloro-6-methylpyridine-3-carboxylate from methanol and 2-chloro-6-methylnicotinic acid was as follows: a. Oxalyl chloride (9.3 mL) was slowly added to a solution of dichloromethane (500 mL) containing 2-chloro-6-methylnicotinic acid (9 g). The reaction mixture was stirred at room temperature for 30 min before the solvent was removed by concentration under reduced pressure to give the crude product. Subsequently, the crude product was dissolved in methanol (500 mL) and processed at 0 °C with stirring. After the reaction mixture was continued to be stirred at room temperature overnight, the solvent was again removed by concentration under reduced pressure to give the residue. The residue was diluted with water and ethyl acetate (EA), neutralized with saturated aqueous sodium bicarbonate solution and subsequently extracted three times with ethyl acetate. The organic layers were combined, washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give methyl 2-chloro-6-methylpyridine-3-carboxylate (9.7 g, 99% yield). The product was characterized by 1H NMR (400 MHz, chloroform-d): δ 2.60 (s, 3H), 3.95 (s, 3H), 7.17 (d, J = 7.8 Hz, 1H), 8.09 (d, J = 7.8 Hz, 1H).
References
[1] Patent: US2011/152312, 2011, A1. Location in patent: Page/Page column 35
[2] Patent: WO2009/100171, 2009, A1. Location in patent: Page/Page column 82
[3] Patent: US2010/144760, 2010, A1. Location in patent: Page/Page column 30; 31
[4] Patent: WO2010/72722, 2010, A1. Location in patent: Page/Page column 50
[5] Patent: WO2006/25783, 2006, A1. Location in patent: Page/Page column 65-66
Methyl 4-chloro-6-methylnicotinate Preparation Products And Raw materials
Raw materials
Preparation Products
Methyl 4-chloro-6-methylnicotinate Suppliers
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- United Kingdom
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View Lastest Price from Methyl 4-chloro-6-methylnicotinate manufacturers
- Product
- Methyl 4-chloro-6-methylnicotinate 53277-47-7
- Price
- US $1.00/KG
- Min. Order
- 1IU
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-02