ChemicalBook > CAS DataBase List > 2-Chloro-5-iodo-4-pyridinamine

2-Chloro-5-iodo-4-pyridinamine

Application

Product Name: 2-Chloro-5-iodo-4-pyridinamine
CAS No.: 800402-12-4
Chemical Name: 2-Chloro-5-iodo-4-pyridinamine
Synonyms: 2-Chloro-5-iodo-4-pyridylamine;2-Chloro-5-iodo-4-pyridinamine;2-chloro-4-amino-5-iodopyridine;2-CHL0R0-5-I0D0-4- PYRIDINAMINE;4-Amino-5-iodo-2-chloropyridine;4-Amino-2-chloro-5-iodopyridine;4-Pyridinamine, 2-chloro-5-iodo-;2-Chloro-5-iodo-pyridin-4-ylamine;4-Amino-2-chloro-5-iodopyridine,95%
CBNumber: CB72484052
Molecular Formula: C5H4ClIN2
Formula Weight: 254.46
MOL File: 800402-12-4.mol

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2-Chloro-5-iodo-4-pyridinamine Property

Melting point:: 126-127°
Boiling point:: 367.8±42.0 °C(Predicted)
Density: 2.139±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
form: solid
pka: 2.96±0.42(Predicted)
Appearance: White to off-white Solid
Sensitive: Light Sensitive
InChI: InChI=1S/C5H4ClIN2/c6-5-1-4(8)3(7)2-9-5/h1-2H,(H2,8,9)
InChIKey: DEJUUKULVAIMNF-UHFFFAOYSA-N
SMILES: C1(Cl)=NC=C(I)C(N)=C1

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Safety

Hazard Codes: Xi
Risk Statements: 22-41
Safety Statements: 26-39
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 765856
Product name: 4-Amino-2-chloro-5-iodopyridine
Purity: 97%
Packaging: 1g
Price: $84
Updated: 2023/06/20

TRC

Product number: C349543
Product name: 2-Chloro-5-iodo-4-pyridinamine
Packaging: 500mg
Price: $130
Updated: 2021/12/16

Matrix Scientific

Product number: 048673
Product name: 2-Chloro-5-iodo-4-pyridinamine
Purity: >95%
Packaging: 500mg
Price: $46
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA57882
Product name: 4-Amino-2-chloro-5-iodopyridine
Packaging: 250mg
Price: $60
Updated: 2021/12/16

Matrix Scientific

Product number: 048673
Product name: 2-Chloro-5-iodo-4-pyridinamine
Purity: >95%
Packaging: 1g
Price: $69
Updated: 2021/12/16

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2-Chloro-5-iodo-4-pyridinamine Chemical Properties,Usage,Production

Application

2-Chloro-5-iodo-4-pyridinamine can be used as an organic intermediate and a pharmaceutical intermediate, mainly in laboratory research and development processes and chemical and pharmaceutical analysis processes.

Synthesis

14432-12-3

800402-12-4

Under nitrogen protection, 2-chloro-4-aminopyridine (15 g, 0.116 mol, 1.0 equiv) was dissolved in acetonitrile (200 mL) and heated to 70 °C in an oil bath. N-iodosuccinimide (NIS, 33 g, 0.139 mol, 1.2 equiv) was slowly added and the reaction mixture was stirred at 70 °C for 16 hours. After completion of the reaction, the reaction was cooled to room temperature and the pH of the reaction system was adjusted to 9-10 by addition of saturated aqueous sodium carbonate. the reaction mixture was extracted with ethyl acetate (500 mL) and the organic phase was separated. The organic phase was washed twice with saturated saline (100 mL) and dried with anhydrous sodium sulfate. The organic phase was concentrated under reduced pressure to give 2-chloro-5-iodo-4-pyridinamine (23 g, 78.1% yield).

References

[1] Patent: CN105622638, 2016, A. Location in patent: Paragraph 0194
[2] Patent: WO2015/38417, 2015, A1. Location in patent: Page/Page column 73; 74
[3] Journal of Medicinal Chemistry, 2012, vol. 55, # 22, p. 10229 - 10240
[4] Journal of Medicinal Chemistry, 2016, vol. 59, # 11, p. 5221 - 5237
[5] Patent: WO2014/207260, 2014, A1. Location in patent: Page/Page column 77

2-Chloro-5-iodo-4-pyridinamine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Chloro-5-iodo-4-pyridinamine manufacturers

Henan Fengda Chemical Co., Ltd

Product: 4-Chloro-2-fluoro-5-iodopyridine 800402-12-4
Price: US $200.00-1.00/KG
Min. Order: 1KG
Purity: 99%, 99.5% Sublimated
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-31

Career Henan Chemical Co

Product: 2-Chloro-5-iodo-4-pyridinamine 800402-12-4
Price: US $1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: Customized
Release date: 2018-12-18

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