2-Chloro-5-iodo-4-pyridinamine
Application- Product Name
- 2-Chloro-5-iodo-4-pyridinamine
- CAS No.
- 800402-12-4
- Chemical Name
- 2-Chloro-5-iodo-4-pyridinamine
- Synonyms
- 2-Chloro-5-iodo-4-pyridylamine;2-Chloro-5-iodo-4-pyridinamine;2-chloro-4-amino-5-iodopyridine;2-CHL0R0-5-I0D0-4- PYRIDINAMINE;4-Amino-5-iodo-2-chloropyridine;4-Amino-2-chloro-5-iodopyridine;4-Pyridinamine, 2-chloro-5-iodo-;2-Chloro-5-iodo-pyridin-4-ylamine;4-Amino-2-chloro-5-iodopyridine,95%
- CBNumber
- CB72484052
- Molecular Formula
- C5H4ClIN2
- Formula Weight
- 254.46
- MOL File
- 800402-12-4.mol
2-Chloro-5-iodo-4-pyridinamine Property
- Melting point:
- 126-127°
- Boiling point:
- 367.8±42.0 °C(Predicted)
- Density
- 2.139±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- solid
- pka
- 2.96±0.42(Predicted)
- Appearance
- White to off-white Solid
- Sensitive
- Light Sensitive
- InChI
- InChI=1S/C5H4ClIN2/c6-5-1-4(8)3(7)2-9-5/h1-2H,(H2,8,9)
- InChIKey
- DEJUUKULVAIMNF-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=C(I)C(N)=C1
N-Bromosuccinimide Price
- Product number
- 765856
- Product name
- 4-Amino-2-chloro-5-iodopyridine
- Purity
- 97%
- Packaging
- 1g
- Price
- $84
- Updated
- 2023/06/20
- Product number
- C349543
- Product name
- 2-Chloro-5-iodo-4-pyridinamine
- Packaging
- 500mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- 048673
- Product name
- 2-Chloro-5-iodo-4-pyridinamine
- Purity
- >95%
- Packaging
- 500mg
- Price
- $46
- Updated
- 2021/12/16
- Product number
- FA57882
- Product name
- 4-Amino-2-chloro-5-iodopyridine
- Packaging
- 250mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 048673
- Product name
- 2-Chloro-5-iodo-4-pyridinamine
- Purity
- >95%
- Packaging
- 1g
- Price
- $69
- Updated
- 2021/12/16
2-Chloro-5-iodo-4-pyridinamine Chemical Properties,Usage,Production
Application
2-Chloro-5-iodo-4-pyridinamine can be used as an organic intermediate and a pharmaceutical intermediate, mainly in laboratory research and development processes and chemical and pharmaceutical analysis processes.
Synthesis
14432-12-3
800402-12-4
Under nitrogen protection, 2-chloro-4-aminopyridine (15 g, 0.116 mol, 1.0 equiv) was dissolved in acetonitrile (200 mL) and heated to 70 °C in an oil bath. N-iodosuccinimide (NIS, 33 g, 0.139 mol, 1.2 equiv) was slowly added and the reaction mixture was stirred at 70 °C for 16 hours. After completion of the reaction, the reaction was cooled to room temperature and the pH of the reaction system was adjusted to 9-10 by addition of saturated aqueous sodium carbonate. the reaction mixture was extracted with ethyl acetate (500 mL) and the organic phase was separated. The organic phase was washed twice with saturated saline (100 mL) and dried with anhydrous sodium sulfate. The organic phase was concentrated under reduced pressure to give 2-chloro-5-iodo-4-pyridinamine (23 g, 78.1% yield).
References
[1] Patent: CN105622638, 2016, A. Location in patent: Paragraph 0194
[2] Patent: WO2015/38417, 2015, A1. Location in patent: Page/Page column 73; 74
[3] Journal of Medicinal Chemistry, 2012, vol. 55, # 22, p. 10229 - 10240
[4] Journal of Medicinal Chemistry, 2016, vol. 59, # 11, p. 5221 - 5237
[5] Patent: WO2014/207260, 2014, A1. Location in patent: Page/Page column 77
2-Chloro-5-iodo-4-pyridinamine Preparation Products And Raw materials
Raw materials
Preparation Products
2-Chloro-5-iodo-4-pyridinamine Suppliers
- Tel
- +49 5662 408730
- Fax
- +49 5662 4087320
- info@synchem.de
- Country
- Germany
- ProdList
- 4705
- Advantage
- 70
View Lastest Price from 2-Chloro-5-iodo-4-pyridinamine manufacturers
- Product
- 4-Chloro-2-fluoro-5-iodopyridine 800402-12-4
- Price
- US $200.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%, 99.5% Sublimated
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-31
- Product
- 2-Chloro-5-iodo-4-pyridinamine 800402-12-4
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2018-12-18