ChemicalBook > CAS DataBase List > 3-Fluoro-4-Bromoobenzyl Cyanide
3-Fluoro-4-Bromoobenzyl Cyanide
Uses- Product Name
- 3-Fluoro-4-Bromoobenzyl Cyanide
- CAS No.
- 499983-13-0
- Chemical Name
- 3-Fluoro-4-Bromoobenzyl Cyanide
- Synonyms
- 3-Fluoro-4-broMobenzyl cyanide;4-Bromo-3-fluorobenzyl cyanide;3-Fluoro-4-Bromoobenzyl Cyanide;4-Bromo-3-fluorophenylacetonitrile;4-Bromo-3-fluorobenzeneacetonitrile;3-Fluoro-4-bromophenyl acetonitrile;Benzeneacetonitrile, 4-bromo-3-fluoro-;2-(4-BroMo-3-fluorophenyl)acetonitrile
- CBNumber
- CB72485635
- Molecular Formula
- C8H5BrFN
- Formula Weight
- 214.03
- MOL File
- 499983-13-0.mol
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3-Fluoro-4-Bromoobenzyl Cyanide Property
- Boiling point:
- 279℃
- Density
- 1.573
- Flash point:
- 122℃
- storage temp.
- 2-8°C
- Appearance
- Off-white to light yellow Solid
- InChI
- InChI=1S/C8H5BrFN/c9-7-2-1-6(3-4-11)5-8(7)10/h1-2,5H,3H2
- InChIKey
- CGDCFGJXTOGEGD-UHFFFAOYSA-N
- SMILES
- C1(CC#N)=CC=C(Br)C(F)=C1
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Safety
- RIDADR
- 3439
- HazardClass
- 6.1
- PackingGroup
- Ⅲ
- HS Code
- 2926907090
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H319Causes serious eye irritation
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
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N-Bromosuccinimide Price
TRC
- Product number
- B677853
- Product name
- 2-(4-Bromo-3-fluorophenyl)acetonitrile
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
AK Scientific
- Product number
- J98092
- Product name
- 4-Bromo-3-fluorophenylacetonitrile
- Packaging
- 5g
- Price
- $60
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 3637-B-X4
- Product name
- 4-Bromo-3-fluorophenylacetonitrile
- Packaging
- 1g
- Price
- $64
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FB105504
- Product name
- 2-(4-bromo-3-fluorophenyl)acetonitrile
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
AK Scientific
- Product number
- J98092
- Product name
- 4-Bromo-3-fluorophenylacetonitrile
- Packaging
- 10g
- Price
- $100
- Updated
- 2021/12/16
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3-Fluoro-4-Bromoobenzyl Cyanide Chemical Properties,Usage,Production
Uses
3-Fluoro-4-bromophenylacetonitrile is a commonly used chemical intermediate, prepared by cyanidation.
Chemical Properties
Off-white powder
Synthesis
127425-73-4
773837-37-9
499983-13-0
A mixture of 3-fluoro-4-bromobenzyl bromide (27 mmol) and sodium cyanide (2.38 g, 54 mmol, 2.0 eq.) in ethanol (100 mL) was heated and reacted at 80 °C for 2 hours. Upon completion of the reaction, the mixture was concentrated to dryness under vacuum, followed by suspension of the residue in water and extraction with ethyl acetate. The organic phase was washed with brine and dried over anhydrous sodium sulfate. The solvent was removed under reduced pressure to give the crude product as a heavy oil. Purification by silica gel column chromatography (eluent gradient: 2%→12% ethyl acetate/hexane) resulted in 3-fluoro-4-bromophenylacetonitrile as white acicular crystals (1.96 g, 35% overall yield in two steps).
References
[1] Patent: WO2011/15287, 2011, A2. Location in patent: Page/Page column 13; 14
[2] Patent: US2011/39934, 2011, A1. Location in patent: Page/Page column 5
[3] Patent: EP2700643, 2014, A1. Location in patent: Paragraph 0235
[4] Patent: US2015/368278, 2015, A1. Location in patent: Paragraph 1263
[5] Patent: WO2017/98440, 2017, A1. Location in patent: Page/Page column 184
3-Fluoro-4-Bromoobenzyl Cyanide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Fluoro-4-Bromoobenzyl Cyanide manufacturers
R&D Scientific Inc.
- Product
- 4-Bromo-3-fluorophenylacetonitrile 499983-13-0
- Price
- US $500.00/g
- Min. Order
- 1g
- Purity
- 98
- Supply Ability
- 500 Kg
- Release date
- 2024-02-12
Career Henan Chemical Co
- Product
- 3-Fluoro-4-Bromoobenzyl Cyanide 499983-13-0
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2020-02-17
499983-13-0, 3-Fluoro-4-Bromoobenzyl CyanideRelated Search:
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