ChemicalBook > CAS DataBase List > PD 153035 HYDROCHLORIDE

PD 153035 HYDROCHLORIDE

Product Name
PD 153035 HYDROCHLORIDE
CAS No.
153436-54-5
Chemical Name
PD 153035 HYDROCHLORIDE
Synonyms
A -1517;PD153035HCl;AG-1517 HCl;Zinc00600292;PD 153035(AG-1517);PD 153035 HYDROCHLORIDE;PD153035;ZM 252868; AG 1517;PD153035 (Tyrphostin AG 1517);PD153035;AG1517;PD-153035;AG-1517;4-Pyrimidinol,2-methoxy-10-methyl-
CBNumber
CB7249204
Molecular Formula
C16H14BrN3O2
Formula Weight
360.21
MOL File
153436-54-5.mol
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PD 153035 HYDROCHLORIDE Property

Melting point:
189-190 °C
Boiling point:
472.1±45.0 °C(Predicted)
Density 
1.499±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
Soluble in DMSO (up to 5 mg/ml).
form 
White to off-white solid.
pka
5.55±0.30(Predicted)
color 
White or off-white
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
18080
Product name
PD 153035
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
18080
Product name
PD 153035
Purity
≥98%
Packaging
5mg
Price
$109
Updated
2024/03/01
Cayman Chemical
Product number
18080
Product name
PD 153035
Purity
≥98%
Packaging
10mg
Price
$184
Updated
2024/03/01
Cayman Chemical
Product number
18080
Product name
PD 153035
Purity
≥98%
Packaging
25mg
Price
$381
Updated
2024/03/01
Tocris
Product number
1037
Product name
PD153035 hydrochloride
Packaging
10
Price
$154
Updated
2021/12/16
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PD 153035 HYDROCHLORIDE Chemical Properties,Usage,Production

Description

AG-1517 HCl (153436-54-5) is an ultra-potent inhibitor of epidermal growth factor receptor tyrosine kinase (EGFR), with an IC50 of 25 pM. Inhibits other tyrosine kinases at micromolar or higher concentrations. It selectively blocks EGF-mediated cellular processes including mitogenesis, early gene expression and oncogenic transformation.1?Inhibits the growth of a number of cancer cell lines.2?AG-1517 HCl is an extremely useful tool for exploring EGF-mediated cellular signaling.3

Chemical Properties

Yellowish solid

Uses

PD 153035 is an extremely potent and specific inhibitor of EGFR tyrosine kinase activity.

Uses

PD153035 is an inhibitor of EGFR, competitive with ATP. EGF Receptor: IC50 = 25 pM (Ki = 6 pM).

Definition

ChEBI: A member of the class of quinazolines carrying a 3-bromophenylamino substituent at position 4 and two methoxy substituents at positions 6 and 7.

Biological Activity

An extremely potent inhibitor of epidermal growth factor (EGF) receptor tyrosine kinase, with an IC 50 of 25 pM. Inhibits other purified tyrosine kinases only at micromolar or higher concentrations.

target

EGFR

References

1) Fry et al. (1994), A specific inhibitor of the epidermal growth factor receptor tyrosine kinase; Science, 265 1093 2) Bos et al. (1997), PD153035, a tyrosine kinase inhibitor, prevents epidermal growth factor receptor activation and inhibits growth of cancer cells in a receptor number-dependent manner; Clin. Cancer Res., 3 2099 3) Tetreault et al. (2008), Specific signaling cascades involved in cell spreading during healing of micro-wounded gastric epithelial monolayers; J. Cell. Biochem., 105 1240

PD 153035 HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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PD 153035 HYDROCHLORIDE Suppliers

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View Lastest Price from PD 153035 HYDROCHLORIDE manufacturers

Career Henan Chemical Co
Product
PD 153035 HYDROCHLORIDE 153436-54-5
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
20kg
Release date
2019-09-05

153436-54-5, PD 153035 HYDROCHLORIDERelated Search:

TCPOBOP TYRPHOSTIN AG 1296 Cantharidin Brefeldin A (1-Bromoethyl)benzene 1-(2-BROMOPHENYL)-2-THIOUREA PD 153035 HYDROCHLORIDE JAK3 INHIBITOR II 4-(3',5'-DIBROMO-4-HYDROXYPHENYL)AMINO-6,7-DIMETHOXYQUINAZOLINE 4-[(3-BROMOPHENYL)AMINO]-6,7-DIETHOXYQUINAZOLINE

  • 4-[(3-BROMOPHENYL)AMINO]-6,7-DIMETHOXYQUINAZOLINE HYDROCHLORIDE
  • PD 153035 HYDROCHLORIDE
  • PD153035HCl
  • PD153035;AG1517;PD-153035;AG-1517;ZM 252868;TYRPHOSTIN AG 1517;SU 5271
  • 4-(3-Bromphenylamino)-6,7-bis(methoxy)quinazoline
  • 4-(3-Bromphenylamino)-6,7-dimethylquinazoline
  • 4-Quinazolinamine, N-(3-bromphenyl)-6,7-dimethoxy-
  • Zinc00600292
  • 4-(3-Bromo-benzyl)-6,7-dimethoxy-quinazoline
  • N-(3-bromophenyl)-6,7-dimethoxyquinazolin-4-amine
  • PD 153035(AG-1517)
  • PD153035;ZM 252868; AG 1517
  • PD153035 (Tyrphostin AG 1517)
  • PD153035;AG1517;PD-153035;AG-1517
  • AG-1517 HCl
  • Phenol,2,2'-[1,7-ethanediylbis[nitrilo(E)methylidyne]]bis-
  • 4-Pyrimidinol,2-methoxy-10-methyl-
  • A -1517
  • 153436-54-5
  • C16H14BrN3O2HCl
  • C16H14BrN3O2
  • Inhibitors
  • Inhibitor