2,5-Difluoro-4-iodopyridine
- Product Name
- 2,5-Difluoro-4-iodopyridine
- CAS No.
- 1017793-20-2
- Chemical Name
- 2,5-Difluoro-4-iodopyridine
- Synonyms
- 2,5-Difluoro-4-iodopyridine;Pyridine, 2,5-difluoro-4-iodo-;2,5-Difluoro-4-iodopyridine ISO 9001：2015 REACH
- CBNumber
- CB72500701
- Molecular Formula
- C5H2F2IN
- Formula Weight
- 240.98
- MOL File
- 1017793-20-2.mol
2,5-Difluoro-4-iodopyridine Property
- Boiling point:
- 209.7±35.0 °C(Predicted)
- Density
- 2.129±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- -4.24±0.18(Predicted)
- Appearance
- Light yellow to light brown Solid
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- D451928
- Product name
- 2,5-Difluoro-4-iodopyridine
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- CS-0005562
- Product name
- 2,5-Difluoro-4-iodopyridine
- Purity
- 98.51%
- Packaging
- 5g
- Price
- $82
- Updated
- 2021/12/16
- Product number
- PC53341
- Product name
- 2,5-Difluoro-4-iodopyridine
- Packaging
- 1g
- Price
- $85
- Updated
- 2021/12/16
- Product number
- 059330
- Product name
- 2,5-Difluoro-4-iodopyridine
- Purity
- 97%
- Packaging
- 5g
- Price
- $89
- Updated
- 2021/12/16
- Product number
- Z6412
- Product name
- 2,5-Difluoro-4-iodopyridine
- Packaging
- 1g
- Price
- $89
- Updated
- 2021/12/16
2,5-Difluoro-4-iodopyridine Chemical Properties,Usage,Production
Synthesis
84476-99-3
1017793-20-2
Preparative Example 2: Synthesis of 2,5-difluoro-4-iodopyridine Diisopropylamine (17 mL, 122 mmol) was added to tetrahydrofuran (220 mL) under nitrogen protection, and the mixture was cooled to -20 °C. Slowly n-butyllithium (49 mL, 122.5 mmol) was added dropwise, and after the drop was completed, the reaction mixture was stirred at -20 °C for 0.5 h and subsequently cooled to -78 °C. At this temperature, a tetrahydrofuran (30 mL) solution of 2,5-difluoropyridine (13.3 g, 115 mmol) was slowly added and the reaction temperature was maintained at -78 °C with stirring for 4 hours. Iodine (32 g, 126 mmol) was dissolved in tetrahydrofuran (100 mL) and slowly added to the above reaction solution and continued to stir at -78 °C for 1 hour. After the reaction was completed, water (10 mL) and tetrahydrofuran (30 mL) were added and slowly warmed to room temperature. The reaction was quenched by the addition of saturated sodium thiosulfate solution. The organic phase was separated and the aqueous phase was extracted with ethyl acetate (3 x 100 mL). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and the filtrate was concentrated. Purification by silica gel column chromatography (eluent: petroleum ether/ethyl acetate=50:1) afforded the target product 2,5-difluoro-4-iodopyridine (13.5 g, 48% yield).
References
[1] Patent: CN104910137, 2017, B. Location in patent: Paragraph 0213-0216
[2] Patent: EP3091008, 2016, A1. Location in patent: Paragraph 0167; 0168
[3] Patent: WO2011/73845, 2011, A1. Location in patent: Page/Page column 116-117
2,5-Difluoro-4-iodopyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,5-Difluoro-4-iodopyridine manufacturers
- Product
- 2,5-Difluoro-4-iodopyridine 1017793-20-2
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-09-01
- Product
- 2,5-Difluoro-4-iodopyridine 1017793-20-2
- Price
- US $6.60/KG
- Min. Order
- 500g
- Purity
- 98%
- Supply Ability
- 1KG, 50KG, 100KG
- Release date
- 2019-12-25