ChemicalBook > CAS DataBase List > 2-[[(1R)-1-[7-methyl-2-(4-morpholinyl)-4-oxo-4h-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid

2-[[(1R)-1-[7-methyl-2-(4-morpholinyl)-4-oxo-4h-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid

Product Name
2-[[(1R)-1-[7-methyl-2-(4-morpholinyl)-4-oxo-4h-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid
CAS No.
1173900-33-8
Chemical Name
2-[[(1R)-1-[7-methyl-2-(4-morpholinyl)-4-oxo-4h-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid
Synonyms
S1462;KIN-193;AZD 6482;AZD6482(r);AZD6482, >=98%;AZD-6482/AZD6482;KIN 193|||AZD6482;AZD 6482 - KIN-193;AZD6482; AZD-6482; AZD 6482.;AZD6482(PI3-kinase β inhibitor)
CBNumber
CB72500943
Molecular Formula
C22H24N4O4
Formula Weight
408.45
MOL File
1173900-33-8.mol
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2-[[(1R)-1-[7-methyl-2-(4-morpholinyl)-4-oxo-4h-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid Property

Boiling point:
635.5±65.0 °C(Predicted)
Density 
1.36
storage temp. 
Store at -20°C
solubility 
insoluble in H2O; ≥20.4 mg/mL in DMSO; ≥6.36 mg/mL in EtOH
form 
solid
pka
3.90±0.50(Predicted)
color 
White to light yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
15250
Product name
AZD6482
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
15250
Product name
AZD6482
Purity
≥98%
Packaging
5mg
Price
$131
Updated
2024/03/01
Cayman Chemical
Product number
15250
Product name
AZD6482
Purity
≥98%
Packaging
10mg
Price
$243
Updated
2024/03/01
Cayman Chemical
Product number
15250
Product name
AZD6482
Purity
≥98%
Packaging
25mg
Price
$533
Updated
2024/03/01
Tocris
Product number
4839
Product name
AZD6482
Purity
≥98%
Packaging
50
Price
$1184
Updated
2021/12/16
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2-[[(1R)-1-[7-methyl-2-(4-morpholinyl)-4-oxo-4h-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid Chemical Properties,Usage,Production

Definition

ChEBI: 2-[[(1R)-1-[7-methyl-2-(4-morpholinyl)-4-oxo-9-pyrido[1,2-a]pyrimidinyl]ethyl]amino]benzoic acid is a pyridopyrimidine.

Biological Activity

azd6428 is a potent, selective and atp-competitive pi3kβ inhibitor. ic50 are 0.69, 13.6, 47.8 and 136 nm for pi 3-kβ, pi 3-kδ, pi 3-kγ and pi 3-kα, respectively.pi3k (phosphatidylinositol-4,5-bisphosphate 3-kinase) is a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer. it plays a key role in pi3k/akt/mtor pathway.

in vitro

azd6482 inhibited insulin-activated uptake of human adpocyte glucose (ic50=4.4 μm). a full anti-thrombotic response with no increased bleeding or blood loss was observed in dog treated with azd6482 in vivo. it also showed good tolerance in a three-hour azd6482 infusion in healthy volunteers. there was an approx.10-20% rise at 5.3 μm (highest plasma concentration) according to the homeostasis model analysis index. [1]

storage

Store at -20°C

References

nylander s, kull b, björkman ja et al. human target validation of phosphoinositide 3-kinase (pi3k)β: effects on platelets and insulin sensitivity, using azd6482 a novel pi3kβ inhibitor. j thromb haemost. 2012 oct;10(10):2127-36.

2-[[(1R)-1-[7-methyl-2-(4-morpholinyl)-4-oxo-4h-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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2-[[(1R)-1-[7-methyl-2-(4-morpholinyl)-4-oxo-4h-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid Suppliers

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View Lastest Price from 2-[[(1R)-1-[7-methyl-2-(4-morpholinyl)-4-oxo-4h-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid manufacturers

Career Henan Chemical Co
Product
2-[[(1R)-1-[7-methyl-2-(4-morpholinyl)-4-oxo-4h-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid 1173900-33-8
Price
US $1.00/KG
Min. Order
1KG
Purity
95%
Supply Ability
500kg
Release date
2018-08-19

1173900-33-8, 2-[[(1R)-1-[7-methyl-2-(4-morpholinyl)-4-oxo-4h-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acidRelated Search:

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  • 2-[[(1R)-1-[7-methyl-2-(4-morpholinyl)-4-oxo-4h-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid
  • AZD 6482
  • AZD6482(PI3-kinase β inhibitor)
  • AZD-6482/AZD6482
  • AZD6482(r)
  • (R)AZD64822-[[(1R)-1-[7-Methyl-2-(4-Morpholinyl)-4-oxo-4h-pyrido[1,2-a]pyriMidin-9-yl]ethyl]aMino]benzoic acid
  • KIN-193
  • 2-[[(1R)-1-[7-Methyl-2-(4-morpholinyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid AZD 6482
  • AZD6482, >=98%
  • S1462
  • AZD 6482, 98%, a PI3Kβ inhibitor
  • 2-[[(1R)-1-[7-Methyl-2-(4-morpholinyl)-4-oxo-4h-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoi
  • (R)-2-(1-(7-Methyl-2-morpholino-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl)ethylamino)benzoic acid
  • AZD6482; AZD-6482; AZD 6482.
  • AZD 6482 - KIN-193
  • Benzoic acid, 2-[[(1R)-1-[7-methyl-2-(4-morpholinyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]-
  • 2-[[(1R)-1-[7-methyl-2-(4-morpholinyl)-4-oxo-4h-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoic acid USP/EP/BP
  • AZD6482 KIN-193 AZD-6482 KIN193
  • KIN 193|||AZD6482
  • 1173900-33-8
  • 173900-33-8
  • Akt
  • mTOR
  • PI3K
  • Inhibitors
  • PI3K/Akt/mTOR