4-[(Biphenyl-2-ylcarbonyl)amino]benzoic acid

ChemicalBook > CAS DataBase List > 4-[(Biphenyl-2-ylcarbonyl)amino]benzoic acid

4-[(Biphenyl-2-ylcarbonyl)amino]benzoic acid

Synthesis

Product Name: 4-[(Biphenyl-2-ylcarbonyl)amino]benzoic acid
CAS No.: 168626-74-2
Chemical Name: 4-[(Biphenyl-2-ylcarbonyl)amino]benzoic acid
Synonyms: Conivaptan-4;Conivaptan impurity D;Conivaptan Impurity 1;Conivaptan intermediate;4-(2-Phenylbenzamido)benzoic acid;Conivaptan hydrochloride Impurity D;4-[(2-phenylbenzoyl)amino]benzoic acid;4-[(2-Biphenylcarbonyl)amino]benzoic acid;4-[(biphenyl-2-carbonyl)amino]benzoic acid;4-[(2-Biphenylylcarbonyl)amino]benzoic acid
CBNumber: CB72510027
Molecular Formula: C20H15NO3
Formula Weight: 317.34
MOL File: 168626-74-2.mol

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4-[(Biphenyl-2-ylcarbonyl)amino]benzoic acid Property

Melting point:: 246-248℃
Boiling point:: 474.5±38.0 °C(Predicted)
Density: 1.29
pka: 4.26±0.10(Predicted)
InChI: InChI=1S/C20H15NO3/c22-19(21-16-12-10-15(11-13-16)20(23)24)18-9-5-4-8-17(18)14-6-2-1-3-7-14/h1-13H,(H,21,22)(H,23,24)
InChIKey: VIWLAZSPFNNYTJ-UHFFFAOYSA-N
SMILES: C(O)(=O)C1=CC=C(NC(C2=CC=CC=C2C2=CC=CC=C2)=O)C=C1

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Safety

HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Matrix Scientific

Product number: 060040
Product name: 4-([1,1'-Biphenyl]-2-ylcarboxamido)benzoic acid
Purity: 90%
Packaging: 5g
Price: $683
Updated: 2021/12/16

AK Scientific

Product number: 5422AD
Product name: 4-([1,1'-Biphenyl]-2-ylcarboxamido)benzoicacid
Packaging: 5g
Price: $972
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0077932
Product name: 4-[(BIPHENYL-2-CARBONYL)AMINO]BENZOIC ACID
Purity: 95.00%
Packaging: 5G
Price: $1501.5
Updated: 2021/12/16

Crysdot

Product number: CD12134821
Product name: 4-([1,1'-Biphenyl]-2-ylcarboxamido)benzoicacid
Purity: 95+%
Packaging: 1g
Price: $50
Updated: 2021/12/16

Crysdot

Product number: CD12134821
Product name: 4-([1,1'-Biphenyl]-2-ylcarboxamido)benzoicacid
Purity: 95+%
Packaging: 5g
Price: $150
Updated: 2021/12/16

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4-[(Biphenyl-2-ylcarbonyl)amino]benzoic acid Chemical Properties,Usage,Production

Synthesis

Thionyl chloride (10.4 g, 87.4 mmol) was added to a mixture of biphenyl-2-carboxylic acid (15.0 g, 75.7 mmol) and DMF (0.28 g, 3.83 mmol) in toluene (72 mL) at an internal temperature of 40 ºC. The mixture was stirred at this temperature for approximately 2 h. After completion of the reaction, the mixture was concentrated to dryness at 60 ºC. The resultant residue was then diluted with toluene (36 mL) and concentrated to dryness at 60 ºC, and the process was repeated again to give biphenyl-2- carbonyl chloride as an oil. Acetone (100 mL) was added to the oil, and 4-amino benzoic acid (10.4 g, 75.8 mmol) and N,N-dimethylaniline (10.1 g, 83.3 mmol) were added to the resultant solution at 25 ºC. The mixture was stirred at this temperature for approximately 2 h. Water (100 mL) was then poured into the mixture, and it was stirred at 25 ºC for more than 1 h. The resultant crystals were collected by fifiltration and dissolved in DMF (100 mL) at 25 ºC. The solution was then fifiltered to remove insoluble materials, water (100 mL) was poured into the fifiltrate, and it was stirred at 25 ºC for approximately 2 h. The resultant crystals were collected by fifiltration and dried at 40 ºC to give the amide as white crystals (22.7 g, 95%).

Reference: Tsunoda, T.; Yamazaki, A.; Mase, T.; Sakamoto, S. Org. Process Res. Dev. 2005, 9, 593–598.

4-[(Biphenyl-2-ylcarbonyl)amino]benzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-[(Biphenyl-2-ylcarbonyl)amino]benzoic acid manufacturers

Career Henan Chemical Co

Product: 4-[(Biphenyl-2-ylcarbonyl)amino]benzoic acid 168626-74-2
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-08

168626-74-2, 4-[(Biphenyl-2-ylcarbonyl)amino]benzoic acidRelated Search:

Ammonium benzoate 4-(CHLOROSULFONYL)BENZOIC ACID 2-Methyl-4-(2-methylbenzamido)benzoic acid 2-Biphenylcarboxylic acid N-(4-(2-Methyl-5,6-dihydro-4H-benzo[b]oxazolo[5,4-d]azepine-6-carbonyl)phenyl)-[1,1'-biphenyl]-2-carboxaMide Conivaptan impurity 2-Methyl-6-[(4-methylphenyl)sulfonyl]-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine 2-Methyl-1,4,5,6-tetrahydroimidazo[4,5-d][1]benzazepine Conivaptan hydrochloride 4-BROMO-1-(TOLUENE-4-SULFONYL)-1,2,3,4-TETRAHYDROBENZO[B]AZEPIN-5-ONE 2-Methyl-5,6-dihydro-4H-benzo[b]oxazolo[5,4-d]azepine 4-Aminobenzoic acid

4-(2-Phenylbenzamido)benzoic acid

4-[(2-Biphenylcarbonyl)amino]benzoic acid

Conivaptan impurity D

Conivaptan intermediate

Conivaptan-4

4-[[oxo-(2-phenylphenyl)methyl]amino]benzoic acid

4-[(Biphenyl-2-ylcarbonyl)amino]benzoic acid

4-([1,1'-Biphenyl]-2-ylcarboxamido)benzoic acid

4-[([1,1'-Biphenyl]-2-carbonyl)aMino]benzoic Acid

Benzoic acid, 4-[([1,1'-biphenyl]-2-ylcarbonyl)aMino]-

Conivaptan hydrochloride Impurity D

4-[([1,1'-biphenyl]-2-ylcarbonyl)amino]Benzoic acid

4-[(2-phenylbenzoyl)amino]benzoic acid

4-([1,1'-biphenyl]-2-carboxamido)benzoic acid

4-[(biphenyl-2-carbonyl)amino]benzoic acid

Conivaptan Impurity 1

3'-Formamido-[1,1':4',1''-terphenyl]-2-carboxylic acid

4-[(2-Biphenylylcarbonyl)amino]benzoic acid

168626-74-2