ChemicalBook > CAS DataBase List > 6-Chloro-N4-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,4-pyrimidinediamine

6-Chloro-N4-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,4-pyrimidinediamine

Product Name
6-Chloro-N4-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,4-pyrimidinediamine
CAS No.
867017-68-3
Chemical Name
6-Chloro-N4-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,4-pyrimidinediamine
Synonyms
BAY-549;TC-S 7001;Azaindole 1;Rho Kinase Inhibitors;TC-S 7001(Azaindole 1);RHO-KINASE INHIBITOR;RHO KINASE INHIBITOR;RHO-KINASE INHIBITOR; RHO KINASE INHIBITOR; ROCK;6-CHLORO-N4-[3,5-DIFLUORO-4-[(3-METHYL-1H-PYRROLO[2,3-B]PYRIDIN-4-YL)OXY]PHENYL]PYRIMIDIN-2,4-DIAMINE;6-Chloro-N4-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,4-pyrimidinediamine;6-Chloro-N4-(3,5-difluoro-4-((3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy)phenyl)pyrimidine-2,4-diamine
CBNumber
CB72510092
Molecular Formula
C18H13ClF2N6O
Formula Weight
402.79
MOL File
867017-68-3.mol
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6-Chloro-N4-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,4-pyrimidinediamine Property

Density 
1.61
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
DMSO: Soluble; Ethanol: Soluble
form 
A solid
pka
13.56±0.40(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
19129
Product name
TC-S 7001
Packaging
500μg
Price
$117
Updated
2024/03/01
Cayman Chemical
Product number
19129
Product name
TC-S 7001
Packaging
1mg
Price
$186
Updated
2024/03/01
Cayman Chemical
Product number
19129
Product name
TC-S 7001
Packaging
5mg
Price
$521
Updated
2024/03/01
Tocris
Product number
4961
Product name
TC-S7001
Purity
≥98%(HPLC)
Packaging
1
Price
$215
Updated
2021/12/16
Usbiological
Product number
466890
Product name
TC-S 7001
Packaging
1mg
Price
$460
Updated
2021/12/16
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6-Chloro-N4-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,4-pyrimidinediamine Chemical Properties,Usage,Production

Uses

TC-S 7001 is a novel potent and highly selective azaindole-based inhibitor of Rho-kinase (ROCK). It exhibits long-acting vasodilator activity and decreases pulmonary and systemic arterial pressure in rats.

storage

Store at -20°C

6-Chloro-N4-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,4-pyrimidinediamine Preparation Products And Raw materials

Raw materials

Preparation Products

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6-Chloro-N4-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,4-pyrimidinediamine Suppliers

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867017-68-3, 6-Chloro-N4-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,4-pyrimidinediamineRelated Search:

5-Chloro-2,3-difluoropyridine Dichlorodifluoromethane 2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)-N-[4-(1-methylpropyl)phenyl]acetamide

  • 6-Chloro-N4-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-2,4-pyrimidinediamine
  • Rho Kinase Inhibitors
  • 6-CHLORO-N4-[3,5-DIFLUORO-4-[(3-METHYL-1H-PYRROLO[2,3-B]PYRIDIN-4-YL)OXY]PHENYL]PYRIMIDIN-2,4-DIAMINE
  • TC-S 7001
  • Azaindole 1
  • RHO-KINASE INHIBITOR;RHO KINASE INHIBITOR
  • RHO-KINASE INHIBITOR; RHO KINASE INHIBITOR; ROCK
  • 2,4-Pyrimidinediamine, 6-chloro-N4-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]-
  • 6-chloro-4-N-[3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl]pyrimidine-2,4-diamine
  • 6-Chloro-N4-(3,5-difluoro-4-((3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy)phenyl)pyrimidine-2,4-diamine
  • inhibit,Rho-kinase,Rho-associated protein kinase,Azaindole-1,ROCKIN2,Rho-associated kinase,Inhibitor,ROCK,ROCK IN 2,Azaindole1,ROK
  • BAY-549
  • TC-S 7001(Azaindole 1)
  • 6-Chloro-N4-(3,5-difluoro-4-((3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy)phenyl)pyrimidine-2,4-diamine , BAY-549
  • 867017-68-3
  • C18H13ClF2N6O
  • 10mg/4780