ChemicalBook > CAS DataBase List > 1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid ethyl ester

1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid ethyl ester

Product Name
1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid ethyl ester
CAS No.
17288-32-3
Chemical Name
1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid ethyl ester
Synonyms
SW-76;SWF-76;Ethyl 4-azaindole-2-carbo...;Ethyl 4-azaindole-2-carboxylate;4,4,5,7-tetramethyl-3,4-dihydrocoumarin;4-Azaindole-2-carboxylic acid ethyl ester;ethyl 1H-pyrrolo[3,2-b]pyridine-2-carbo×ylate;Ethyl 1H-pyrrolo[3,2-b]pyridine-2-carboxylate;1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid ethyl ester
CBNumber
CB72514656
Molecular Formula
C10H10N2O2
Formula Weight
190.2
MOL File
17288-32-3.mol
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1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid ethyl ester Property

Melting point:
179-181℃
Boiling point:
356℃
Density 
1.272
Flash point:
169℃
storage temp. 
Sealed in dry,Room Temperature
pka
12.67±0.40(Predicted)
Appearance
Off-white to yellow Solid
InChI
InChI=1S/C10H10N2O2/c1-2-14-10(13)9-6-8-7(12-9)4-3-5-11-8/h3-6,12H,2H2,1H3
InChIKey
NOWHXIDXMNNYBL-UHFFFAOYSA-N
SMILES
C12C=C(C(OCC)=O)NC1=CC=CN=2
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
E926493
Product name
Ethyl1H-Pyrrolo[3,2-b]pyridine-2-carboxylate
Packaging
100mg
Price
$75
Updated
2021/12/16
SynQuest Laboratories
Product number
4H58-1-J3
Product name
Ethyl 4-azaindole-2-carboxylate
Packaging
1g
Price
$150
Updated
2021/12/16
SynQuest Laboratories
Product number
4H58-1-J3
Product name
Ethyl 4-azaindole-2-carboxylate
Packaging
5G
Price
$500
Updated
2021/12/16
Matrix Scientific
Product number
112347
Product name
Ethyl 4-azaindole-2-carboxylate
Packaging
1g
Price
$662
Updated
2021/12/16
AK Scientific
Product number
Z4286
Product name
Ethyl1H-pyrrolo[3,2-b]pyridine-2-carboxylate
Packaging
25g
Price
$761
Updated
2021/12/16
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1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid ethyl ester Chemical Properties,Usage,Production

Synthesis

23596-34-1

17288-32-3

The general procedure for the synthesis of ethyl 4-azaindole-2-carboxylate (4a-1) from the compound (CAS: 23596-34-1) was as follows: ethyl 1H-pyrrolo[3,2-b]pyridine-2-carboxylate (56.8 g, 0.24 mol), ethanol (850 mL), and 10% Pd/C (5.7 g, 10 wt%) were added to a 2 L thick-walled Parr reactor. The reactor was connected to the Parr hydrogenation unit and after flushing with hydrogen, the orange slurry was pressurized to 45 psi. the reaction temperature was raised to 57 °C by shaking for 1 h at room temperature. After the temperature of the reaction mixture stabilized at 35°C, it was slowly heated to 40°C and maintained for 3 hr. After confirming the completion of the reaction by TLC (silica gel plate, unfolding agent was CH2Cl2 solution with 1% MeOH), the reaction mixture was cooled to room temperature, the slurry was filtered through Celite and the filter cake was washed with ethanol (4 x 200 mL). The yellow filtrate was concentrated to obtain a solid (41.6 g), to which ethyl acetate (302 mL) was added and heated on a steam bath. After cooling the mixture to room temperature, heptane (600 mL) was added to precipitate the product. The mixture was stirred in an ice bath for 1 hour and then filtered and the filter cake was washed with heptane (100 mL). The filter cake was dried at 50 °C, 0.1 mmHg for 24 h to give light gray solid 4a-1 (36.6 g, 81% yield).1H NMR (DMSO-d6) δ 1.36 (t, 3H, J=7.0 Hz), 4.36 (q, 2H, J=7.0 Hz), 7.19 (s, 1H), 7.25 (dd, 1H, J=4.5, 8.1 Hz), 7.82 (d, 1H, J=8.1 Hz), 8.44 (d, 1H, J=4.5 Hz), 12.11 (s, 1H).

References

[1] Organic Process Research and Development, 2011, vol. 15, # 5, p. 1040 - 1045
[2] Patent: US2005/131012, 2005, A1. Location in patent: Page/Page column 14
[3] Patent: US2005/131012, 2005, A1. Location in patent: Page/Page column 14
[4] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 1, p. 339 - 342
[5] Patent: US2005/131012, 2005, A1. Location in patent: Page/Page column 14

1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid ethyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid ethyl ester Suppliers

China 80 Germany 1 India 2 Ukraine 1 United States 17 Global 101
Tianjin Ruide Famo Technology Co., Ltd
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13821803402
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Zhongshan Kexin Biotechnology Co., Ltd
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0760-+86-0760-88665202 13824707890
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JinYan Chemicals(ShangHai) Co.,Ltd.
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Jia Xing Isenchem Co.,Ltd
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0573-85285100 18627885956
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Pure Chemistry Scientific Inc.
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001-857-928-2050 or 1-888-588-9418
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001-617-206-9595
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Adamas Reagent, Ltd.
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021-64823266
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China DongFan Chemical Co.,LTD
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Anhui Shite Pharmaceutical Technology Co., LTD
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0512-63261912
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Dtchem Laboratories,（Gan Su）Co.,Ltd.
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18993966060
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0943-8288977
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sales@techbiochem.com
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Shijiazhuang suchen Chemical Technology Co. LTD
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186-33933494 18032288352
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View Lastest Price from 1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid ethyl ester manufacturers

Career Henan Chemical Co
Product
1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid ethyl ester 17288-32-3
Price
US $5.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2020-01-12

17288-32-3, 1H-Pyrrolo[3,2-b]pyridine-2-carboxylic acid ethyl esterRelated Search:

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