ChemicalBook > CAS DataBase List > SC-1

SC-1

Product Name: SC-1
CAS No.: 1313019-65-6
Chemical Name: SC-1
Synonyms: SC-1;Compound SC-1;SC-1 >=98% (HPLC);1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea;N-[4-Chloro-3-(trifluoromethyl)phenyl]-N′-[4-(4-cyanophenoxy)phenyl]-urea;Urea, N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-[4-(4-cyanophenoxy)phenyl]-;1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea - [C93284];1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea, 10 mM in DMSO;STAT,cyclin-D1,Inhibitor,inhibit,kinase,Apoptosis,1(4Chloro3(trifluoromethyl)phenyl)3(4(4cyanophenoxy)phenyl)urea,p-STAT3,orally,anticancer,SHP-1,1 (4 Chloro 3 (trifluoromethyl)phenyl) 3 (4 (4 cyanophenoxy)phenyl)urea,survivin
CBNumber: CB72520383
Molecular Formula: C21H13ClF3N3O2
Formula Weight: 431.8
MOL File: 1313019-65-6.mol

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SC-1 Property

storage temp.: 2-8°C
solubility: DMSO: soluble15mg/mL, clear
form: powder
color: white to beige
Water Solubility: Water: Insoluble

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Safety

Hazard Codes: Xi
Risk Statements: 36
Safety Statements: 26
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H319Causes serious eye irritation

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P273Avoid release to the environment.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0858
Product name: SC-1
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $107
Updated: 2025/07/31

Sigma-Aldrich

Product number: CB_86060301
Product name: SC-1
Purity: NOTE: Both the cell line and DNA from the cell line may be available for this product. Please choose -1VL or VIAL for cells, or -DNA-5UG for DNA, 86060301, mouse embryo, Fibroblast
Packaging: 1 unit
Price: $402
Updated: 2025/07/31

Sigma-Aldrich

Product number: CB_86060301
Product name: SC-1
Purity: NOTE: Both the cell line and DNA from the cell line may be available for this product. Please choose -1VL or VIAL for cells, or -DNA-5UG for DNA, 86060301, mouse embryo, Fibroblast
Packaging: 1 vial
Price: $847
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML0858
Product name: SC-1
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $409
Updated: 2023/01/07

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SC-1 Chemical Properties,Usage,Production

Uses

STAT3-IN-7 is a Sorafenib analogue and potently inhibits the phosphorylation of STAT3. STAT3-IN-7 induces cell apoptosis through SHP-1 dependent STAT3 inactivation. STAT3-IN-7 does not inhibit kinase activity and has anticancer effects[1].

Biological Activity

SC-1 is a derivative of the multiple tyrosine kinase inhibitor sorafenib with no kinase-inhibition activity. SC-1 blocks STAT3 phosphorylation and activation with similar potency to sorafenib, and induces apoptosis in hepatocellular carcinoma cell lines.

in vivo

STAT3-IN-7 (10 mg/kg; oral gavage; daily; for 28 days; female NCr athymic nude mice) treatment shows efficacious antitumor activity and p-STAT3 downregulation in MDA-MB-468 xenograft tumors^[1].

Animal Model:	Female NCr athymic nude mice (4-6 weeks of age) injected with breast cancer cells ^[1]
Dosage:	10 mg/kg
Administration:	Oral gavage; daily; for 28 days
Result:	Showed efficacious antitumor activity and p-STAT3 downregulation in MDA-MB-468 xenograft tumors.

IC 50

p-STAT3

References

[1] Chun-Yu Liu, et al. Novel sorafenib analogues induce apoptosis through SHP-1 dependent STAT3 inactivation in human breast cancer cells. Breast Cancer Res. 2013;15(4):R63. DOI:10.1186/bcr3457

SC-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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SC-1 Suppliers

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1313019-65-6, SC-1Related Search:

BNL CL.2 G-Olig2 SC-43 4-ThiazolecarboxaMide, N-(6-benzoyl-1H-benziMidazol-2-yl)-2-(1-thieno[3,2-d]pyriMidin-4-yl-4-piperidinyl)- SC-560 4-[5-(4-CHLOROPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]BENZENESULFONAMIDE α,α-Diphenyl-4-[(3-pyridinylmethylene)amino]-1-piperazinepentanenitrile

SC-1

N-[4-Chloro-3-(trifluoromethyl)phenyl]-N′-[4-(4-cyanophenoxy)phenyl]-urea

Urea, N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-[4-(4-cyanophenoxy)phenyl]-

SC-1 >=98% (HPLC)

1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea

STAT,cyclin-D1,Inhibitor,inhibit,kinase,Apoptosis,1(4Chloro3(trifluoromethyl)phenyl)3(4(4cyanophenoxy)phenyl)urea,p-STAT3,orally,anticancer,SHP-1,1 (4 Chloro 3 (trifluoromethyl)phenyl) 3 (4 (4 cyanophenoxy)phenyl)urea,survivin

Compound SC-1

1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea, 10 mM in DMSO

1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea - [C93284]

1313019-65-6

C21H13ClF3N3O2