NVP-BHG712
- Product Name
- NVP-BHG712
- CAS No.
- 940310-85-0
- Chemical Name
- NVP-BHG712
- Synonyms
- CS-688;CS-475;NSC5175;NSC 5175;NSC-5175;NVP-BHG712;NVP-BHG712 (BHG712);NVP-BHG712 USP/EP/BP;NVP-BHG 712; NVP BHG 712;4-Methyl-3-(1-methyl-6-(pyridin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylamino)-N-(3-(trifluorome
- CBNumber
- CB72522978
- Molecular Formula
- C26H20F3N7O
- Formula Weight
- 503.48
- MOL File
- 940310-85-0.mol
NVP-BHG712 Property
- Density
- 1.41
- storage temp.
- -20°C
- solubility
- DMSO: >15mg/mL
- form
- powder
- pka
- 13.20±0.70(Predicted)
- color
- white to beige
N-Bromosuccinimide Price
- Product number
- SML0333
- Product name
- NVP-BHG 712
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $158
- Updated
- 2024/03/01
- Product number
- SML0333
- Product name
- NVP-BHG 712
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $661
- Updated
- 2024/03/01
- Product number
- N1099
- Product name
- NVP-BHG 712
- Purity
- >95.0%(HPLC)
- Packaging
- 50mg
- Price
- $455
- Updated
- 2024/03/01
- Product number
- N1099
- Product name
- NVP-BHG 712
- Purity
- >95.0%(HPLC)
- Packaging
- 10mg
- Price
- $146
- Updated
- 2022/04/27
- Product number
- 18489
- Product name
- NVP-BHG 712
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
NVP-BHG712 Chemical Properties,Usage,Production
Uses
NVP-BHG712 is a small molecule specific EphB4, VEGFR2, c-raf, c-src and c-Abl kinase inhibitor with ED50 of 25 nM, 4.2, 0.4, 1.3 and 1.7μM, respectively.
Uses
NVP-BHG712 can be used in biological study and therapeutic use of combinations of kinase inhibitors for treating colorectal cancer.
Definition
ChEBI: 4-methyl-3-[[1-methyl-6-(3-pyridinyl)-4-pyrazolo[3,4-d]pyrimidinyl]amino]-N-[3-(trifluoromethyl)phenyl]benzamide is a member of benzamides.
Biochem/physiol Actions
NVP-BHG712 is a very potent, selective inhbitor of the receptor tyrosine kinase EphB4 (ED50 = 25 nM). NVP-BHG712 blocks Ephrin receptor autophosphorylation and VEGF-induced angiogenesis.
References
[1]. martiny-baron, g., et al., the small molecule specific ephb4 kinase inhibitor nvp-bhg712 inhibits vegf driven angiogenesis. angiogenesis, 2010. 13(3): p. 259-67.
[2]. kathawala, r.j., et al., the small molecule tyrosine kinase inhibitor nvp-bhg712 antagonizes abcc10-mediated paclitaxel resistance: a preclinical and pharmacokinetic study. oncotarget, 2015. 6(1): p. 510-21.
[3]. becerikli, m., et al., ephb4 tyrosine-kinase receptor expression and biological significance in soft tissue sarcoma. int j cancer, 2015. 136(8): p. 1781-91.
NVP-BHG712 Preparation Products And Raw materials
Raw materials
Preparation Products
NVP-BHG712 Suppliers
- Tel
- 03-36680489
- Fax
- 03-3668-0520
- Sales-JP@TCIchemicals.com
- Country
- Japan
- ProdList
- 28387
- Advantage
- 80