Prolactin-Releasing Peptide (1-31) (human)
- Product Name
- Prolactin-Releasing Peptide (1-31) (human)
- CAS No.
- 215510-22-8
- Chemical Name
- Prolactin-Releasing Peptide (1-31) (human)
- Synonyms
- Human PrRP-31;PrRP31 (huMan), Preprolactin (23-53) (huMan);H-Ser-Arg-Thr-His-Arg-His-Ser-Met-Glu-Ile-Arg-Thr-Pro-Asp-Ile-Asn-Pro-Ala-Trp-Tyr-Ala-Ser-Arg-Gly-Ile-Arg-Pro-Val-Gly-Arg-Phe-NH2
- CBNumber
- CB72524907
- Molecular Formula
- C160H252N56O42S
- Formula Weight
- 3664.12788
- MOL File
- 215510-22-8.mol
Prolactin-Releasing Peptide (1-31) (human) Property
- solubility
- Water: 1 mg/ml
- form
- A lyophilized powder
- color
- White to off-white
- Sequence
- Ser-Arg-Thr-His-Arg-His-Ser-Met-Glu-Ile-Arg-Thr-Pro-Asp-Ile-Asn-Pro-Ala-Trp-Tyr-Ala-Ser-Arg-Gly-Ile-Arg-Pro-Val-Gly-Arg-Phe-NH2
N-Bromosuccinimide Price
- Product number
- 24986
- Product name
- Prolactin-Releasing Peptide (1-31) (human)
- Purity
- ≥95%
- Packaging
- 500μg
- Price
- $364
- Updated
- 2024/03/01
Prolactin-Releasing Peptide (1-31) (human) Chemical Properties,Usage,Production
Uses
Prolactin Releasing Peptide (1-31), human is a high affinity GPR10 ligand that cause the release of the prolactin. Prolactin Releasing Peptide (1-31) binds to GPR10 for human and rats with Ki values of 1.03 nM and 0.33 nM, respectively. Prolactin Releasing Peptide (1-31) can be used for the research of the hypothalamo-pituitary axis[1][2].
in vivo
Prolactin Releasing Peptide (1-31) (human) (ICV, 5 nM) increases plasma FSH, total plasma testosterone and significantly increased the release of LHRH from hypothalamic explants in vitro[2].
Prolactin Releasing Peptide (1-31) (human) (ICV, 100 nM) increases the hypothalanic peptides involved in the control of pituitary hormone release, vasoactive intestinal peptide (VIP) and galanin but had no effect on orexin A secretion[2].
References
[1] Langmead CJ, et al. Characterization of the binding of [(125)I]-human prolactin releasing peptide (PrRP) to GPR10, a novel G protein coupled receptor. Characterization of the binding of [(125)I]-human prolactin releasing peptide (PrRP) to GPR10, a novel G protein coupled receptor. DOI:10.1038/sj.bjp.0703617
[2] L J Seal, et al. Prolactin releasing peptide (PrRP) stimulates luteinizing hormone (LH) and follicle stimulating hormone (FSH) via a hypothalamic mechanism in male rats. Endocrinology. 2000 May;141(5):1909-12. DOI:10.1210/endo.141.5.7528
Prolactin-Releasing Peptide (1-31) (human) Preparation Products And Raw materials
Raw materials
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