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METHYL 2-BROMO-5-METHOXYBENZOATE

Product Name
METHYL 2-BROMO-5-METHOXYBENZOATE
CAS No.
35450-36-3
Chemical Name
METHYL 2-BROMO-5-METHOXYBENZOATE
Synonyms
RARECHEM AL BF 1111;Methyl 6-Bromo-m-anisate;METHYL 2-BROMO-5-METHOXYBENZOATE;2-bromo-5-methoxy methylbenzoate;2-bromo-5-methoxy-3-methylbenzoate;6-Bromo-m-anisic Acid Methyl Ester;Methyl2-Bromo-5-methoxybenzoate>Methyl 2-bromo-5-methoxybenzoate 97%;Methyl 2-bromo-5-methoxybenzoate-98%;Methyl 2-bromo-5-methoxybenzoate, 97%
CBNumber
CB7252824
Molecular Formula
C9H9BrO3
Formula Weight
245.07
MOL File
35450-36-3.mol
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METHYL 2-BROMO-5-METHOXYBENZOATE Property

Boiling point:
271 °C
Density 
1.520 g/mL at 25 °C
refractive index 
n20/D 1.563
Flash point:
>230 °F
storage temp. 
Sealed in dry,Room Temperature
form 
clear liquid
color 
Colorless to Light yellow to Light orange
Water Solubility 
Not miscible in water.
BRN 
2641378
CAS DataBase Reference
35450-36-3(CAS DataBase Reference)
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
UN 2810 6.1/PG 3
WGK Germany 
3
Hazard Note 
Toxic
HS Code 
29189900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
659290
Product name
Methyl 2-bromo-5-methoxybenzoate
Purity
97%
Packaging
5g
Price
$37.71
Updated
2025/07/31
Sigma-Aldrich
Product number
659290
Product name
Methyl 2-bromo-5-methoxybenzoate
Purity
97%
Packaging
25g
Price
$103.6
Updated
2025/07/31
TCI Chemical
Product number
M1934
Product name
Methyl 2-Bromo-5-methoxybenzoate
Purity
>98.0%(GC)
Packaging
5g
Price
$32
Updated
2025/07/31
TCI Chemical
Product number
M1934
Product name
Methyl 2-Bromo-5-methoxybenzoate
Purity
>98.0%(GC)
Packaging
25g
Price
$110
Updated
2025/07/31
TRC
Product number
M258705
Product name
Methyl 2-Bromo-5-methoxybenzoate
Packaging
10g
Price
$85
Updated
2021/12/16
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METHYL 2-BROMO-5-METHOXYBENZOATE Chemical Properties,Usage,Production

Chemical Properties

Colorless liquid

Uses

Methyl 2-bromo-5-methoxybenzoate is used as pharmaceutical intermediate.

Synthesis

67-56-1

22921-68-2

35450-36-3

To a stirred solution of 2-bromo-5-methoxybenzoic acid (5.0 g, 21.6 mmol) in methanol (80 mL) was slowly added concentrated hydrochloric acid (2 mL). The reaction mixture was heated to reflux and stirred continuously for 18 hours. Upon completion of the reaction, the solution was cooled to room temperature and the solvent was subsequently evaporated under reduced pressure. Water (100 mL) was added to the residue and extracted with ethyl acetate (2 x 100 mL). The organic phases were combined and washed with saturated aqueous sodium bicarbonate to remove unreacted acid. The organic layer was dried over anhydrous magnesium sulfate, filtered and concentrated to give methyl 2-bromo-5-methoxybenzoate as a light brown oil (4.50 g, 85% yield). The product was confirmed by NMR hydrogen spectrum (300 MHz, CDCl3): δH 7.53 (1H, d, J=8.8 Hz, 3-H), 7.32 (1H, d, J=3.0 Hz, 6-H), 6.89 (1H, dd, J=3.0, 8.8 Hz, 4-H), 3.94 (3H, s, ArOCH3), 3.82 (3H, s. CO2CH3). Infrared spectroscopy (thin-film method) showed characteristic absorption peaks: 2951, 1732 (C=O), 1592, 1472, 1433, 1289, 1250, 1227, 1099, 1017, 975, 823, 792 cm-1. Thin-layer chromatography (unfolding reagent: hexane-ethyl acetate, 5:1) showed Rf-value of 0.58. All the data are in agreement with the literature reports ( Barhate, NB; Gajare, AS; Wakharkar, RD; Bedekar, AV Tetrahedron 1999,55,11127-11142).

References

[1] Tetrahedron, 1998, vol. 54, # 37, p. 11209 - 11234
[2] Journal of Organic Chemistry, 2003, vol. 68, # 11, p. 4586 - 4589
[3] Patent: WO2012/102985, 2012, A1. Location in patent: Page/Page column 111
[4] Patent: WO2008/75048, 2008, A2. Location in patent: Page/Page column 64-65
[5] Tetrahedron, 1995, vol. 51, # 37, p. 10115 - 10124

METHYL 2-BROMO-5-METHOXYBENZOATE Preparation Products And Raw materials

Raw materials

3-Methoxybenzoic acid Bromine Acetic acid Sodium hydroxide Magnesium sulfate Sulfuric acid

Preparation Products

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35450-36-3, METHYL 2-BROMO-5-METHOXYBENZOATERelated Search:

METHYL 2-BROMO-5-METHOXYBENZOATE 4-BROMO-7-METHOXY-BENZO[1,3]DIOXOLE-5-CARBOXYLIC ACID METHYL ESTER Methyl 4-acetamido-5-bromo-2-methoxybenzoate METHYL 3-BROMO-4-METHOXYBENZOATE, PURISS, 98%,METHYL 3-BROMO-4-METHOXYBENZOATE 98 METHYL 4-BROMO-3-METHOXYBENZOATE METHYL 4-BROMO-2-METHOXYBENZOATE 98,METHYL 4-BROMO-2-METHOXYBENZOATE, PURISS 2-BROMO-5-METHOXYBENZOIC ACID METHYL 4-BROMO-2-METHOXYBENZOATE AKOS B029725 AURORA 17163 RARECHEM AL BI 0230 AURORA 17241 AURORA 5302 AURORA 17290 AURORA 17311 AURORA 17296 RARECHEM AL BF 0230 RARECHEM AL BF 0271

  • 2-BROMO-5-METHOXYBENZOIC ACID METHYL ESTER
  • METHYL 2-BROMO-5-METHOXYBENZOATE
  • RARECHEM AL BF 1111
  • 2-bromo-5-methoxy-3-methylbenzoate
  • 2-Bromo-5-methoxybenzoic Acid Methyl Ester Methyl 6-Bromo-m-anisate 6-Bromo-m-anisic Acid Methyl Ester
  • Benzoic acid, 2-broMo-5-Methoxy-, Methyl ester
  • Methyl 2-bromo-5-methoxybenzoate 97%
  • Methyl2-Bromo-5-methoxybenzoate&gt
  • 6-Bromo-m-anisic Acid Methyl Ester
  • Methyl 6-Bromo-m-anisate
  • Methyl 2-bromo-5-methoxybenzoate-98%
  • 2-bromo-5-methoxy methylbenzoate
  • Methyl 2-bromo-5-methoxybenzoate, 97%
  • 35450-36-3
  • Carbonyl Compounds
  • C8 to C9
  • Building Blocks
  • Organic Building Blocks
  • Esters
  • ARYL HALIDE
  • Building Blocks
  • C8 to C9
  • Carbonyl Compounds
  • Chemical Synthesis
  • Organic Building Blocks
  • blocks
  • Bromides
  • Carboxes
  • Aromatic Esters
  • Acids & Esters
  • Anisoles, Alkyloxy Compounds & Phenylacetates
  • Bromine Compounds
  • C8 to C9
  • Carbonyl Compounds
  • Esters