5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine

Product Name: 5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine
CAS No.: 733039-20-8
Chemical Name: 5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine
Synonyms: Xylose Impurity 9;5-BROMO-2-CHLORO-N-CYCLOPEN;2-bromo-2-chloro-N-cyclopentylpyrimidin-4-amine;5-Bromo-2-chloro-N-cyclopentyl-4-pyrimidinamine;5-Bromo-2-chloro-4-(cyclopentylamino)pyrimidine;5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine;5-Bromo-2-chloro-N-cyclopentylamine-4-pyrimidine;4-PyriMidinaMine, 5-broMo-2-chloro-N-cyclopentyl-;(5-Bromo-2-chloro-pyrimidin-4-yl)-cyclopentyl-amine;N-(5-Bromo-2-chloropyrimidin-4-yl)(cyclopentyl)amine
CBNumber: CB72554173
Molecular Formula: C9H11BrClN3
Formula Weight: 276.56
MOL File: 733039-20-8.mol

More

Less

5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine Property

Boiling point:: 424.0±30.0 °C(Predicted)
Density: 1.643±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
form: solid
pka: 1.22±0.10(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C9H11BrClN3/c10-7-5-12-9(11)14-8(7)13-6-3-1-2-4-6/h5-6H,1-4H2,(H,12,13,14)
InChIKey: DIVUXBABVYOIOT-UHFFFAOYSA-N
SMILES: C1(Cl)=NC=C(Br)C(NC2CCCC2)=N1

More

Less

Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

TRC

Product number: B733030
Product name: 5-Bromo-2-chloro-N-cyclopentyl-4-pyrimidinamine
Packaging: 250mg
Price: $45
Updated: 2021/12/16

AK Scientific

Product number: Y6372
Product name: 5-Bromo-2-chloro-N-cyclopentylpyrimidin-4-amine
Packaging: 5g
Price: $77
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0366826
Product name: 5-BROMO-2-CHLORO-N-CYCLOPENTYLPYRIMIDIN-4-AMINE
Purity: 95.00%
Packaging: 5MG
Price: $504.11
Updated: 2021/12/16

Matrix Scientific

Product number: 096534
Product name: 5-Bromo-2-chloro-N-cyclopentylpyrimidin-4-amine
Purity: 95+%
Packaging: 5g
Price: $660
Updated: 2021/12/16

Matrix Scientific

Product number: 096534
Product name: 5-Bromo-2-chloro-N-cyclopentylpyrimidin-4-amine
Purity: 95+%
Packaging: 1g
Price: $225
Updated: 2021/12/16

More

Less

5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine Chemical Properties,Usage,Production

Uses

5-Bromo-2-chloro-N-cyclopentyl-4-pyrimidinamine is an intermediate in the preparation of 2-aminopyridines as cdk4 inhibitors for treating cell proliferative disorders.

Synthesis

36082-50-5

1003-03-8

733039-20-8

5-Bromo-2,4-dichloropyrimidine (45.6 g, 200 mmol) was dissolved in dioxane (400 mL) at room temperature and subsequently cyclopentylamine (20.4 g, 240 mmol) was added to the solution. The reaction mixture was stirred continuously for 6 hours at room temperature. After completion of the reaction, the reaction mixture was diluted with ethyl acetate, washed sequentially with saturated brine and dried over anhydrous magnesium sulfate. The solvent was removed by concentration under reduced pressure to afford 5-bromo-2-chloro-N-cyclopentyl-4-pyrimidinamine as a light yellow solid (56 g, 100% yield), which could be used in subsequent reactions without further purification. The product was characterized as follows: 1H NMR (500 MHz, DMSO-d6) δ 8.23 (1H, s), 7.37 (1H, d, J = 7.3 Hz), 4.31 (1H, m), 1.92 (2H, m), 1.71 (2H, m), 1.53-1.59 (4H, m) ppm; LCMS-ESI (POS), m/z [M + H]+: measured value 276.0, calculated value 275.9.

References

[1] Patent: WO2009/85185, 2009, A1. Location in patent: Page/Page column 35
[2] Journal of Medicinal Chemistry, 2014, vol. 57, # 8, p. 3430 - 3449
[3] Combinatorial Chemistry and High Throughput Screening, 2017, vol. 20, # 8, p. 703 - 712
[4] Patent: WO2010/20675, 2010, A1. Location in patent: Page/Page column 89
[5] Patent: US2012/115878, 2012, A1. Location in patent: Page/Page column 5-6

5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine Suppliers

China 282 India 6 United States 7 Global 295

Hunan Eurasian Pharmaceutical Co. Ltd.

Tel: 0592-5789919 13328776692
Email: 2851802016@qq.com
Country: China
ProdList: 79
Advantage: 58

Suzhou Carbonwell Pharma-Tech Co., Ltd

Tel: 0512-0512-88981216 13776013740
Email: 1320558046@qq.com
Country: China
ProdList: 72
Advantage: 58

China Shenyang Tyschem CO. ,LTD

Tel: +86-024-83607930; 18640359690
Fax: 024-83607930
Email: sales@honghuchem.com
Country: China
ProdList: 256
Advantage: 58

Shandong Zhongke Taidou Chemical Co., Ltd.

Tel: 0531-88682301 18595278760
Fax: 0531-62325738
Email: sdzkzf@sdzktd.com
Country: China
ProdList: 112
Advantage: 62

Shandong Xuande Pharmaceutical Technology Co. LTD

Tel: 18866895588
Fax: 0531-82777287
Email: dingjiaying@shiningpharm.com
Country: China
ProdList: 163
Advantage: 55

Nantong Xiaochang Pharmaceutical Trading Co., Ltd.

Tel: 0513-82104991 18912868361
Fax: QQ1907456386
Email: sales11@btcpharm.com
Country: China
ProdList: 1250
Advantage: 58

BTC Pharmaceutical CO. Ltd

Tel: 15716293042 18862996710
Fax: 0513-68015394
Email: 15050603958@163.com
Country: China
ProdList: 694
Advantage: 55

TIANJIN PHARMACN MEDICAL TECHNOLOGY CO.,LTD.

Tel: 022-60189726 18812034280
Fax: 86-22-60979672
Email: 188120342808@163.com
Country: China
ProdList: 142
Advantage: 61

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14101
Advantage: 59

More

Less

View Lastest Price from 5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine 733039-20-8
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 10000KGS
Release date: 2025-06-04

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 5-Bromo-2-chloro-N-cyclopentylpyrimidin-4-amine 733039-20-8
Price: US $79.00-38.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-11-13

Henan Fengda Chemical Co., Ltd

Product: 5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine 733039-20-8
Price: US $10.00-2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-28

733039-20-8, 5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMineRelated Search:

10-Hydroxy Warfarin β-D-Glucuronide 4-Methoxyphenethylamine 2-(2,4-Difluorophenyl)-2-propenyl-propanedioic Acid Diethyl Ester 2-Acetyloxy-1(2,4-difluorophenyl)ethanone D-alpha-Amino-epsilon-caprolactam 2,3-DIMETHOXYPHENETHYLAMINE 3-Methoxyphenethylamine 3-(3,4-DIMETHOXY-PHENYL)-PROPYLAMINE 3,4,5-Trimethoxyphenylacetonitrile 5-(Chloromethyl)-1,2,3-trimethoxybenzene Benzeneacetic acid, 2,4,5-triMethoxy- 1-2-(2,4-difluorophenyl)-2-propenol acetate Pyrazinecarboxylic acid, 5-methyl-, 1-oxide (9CI) methyl 5-bromo-2-chloro-3-hydroxybenzoate 5-Bromo-2-fluoro-3-methylanisole

5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine

4-PyriMidinaMine, 5-broMo-2-chloro-N-cyclopentyl-

N-(5-Bromo-2-chloropyrimidin-4-yl)(cyclopentyl)amine

5-Bromo-2-chloro-4-(cyclopentylamino)pyrimidine

(5-Bromo-2-chloro-pyrimidin-4-yl)-cyclopentyl-amine

5-Bromo-2-chloro-N-cyclopentyl-4-pyrimidinamine

2-bromo-2-chloro-N-cyclopentylpyrimidin-4-amine

5-broMo-2-chloro-N-cyclopentylpyriMidin-4-aMine ISO 9001：2015 REACH

5-BROMO-2-CHLORO-N-CYCLOPEN

6-Acetyl-8-cyclopentyl-5-methyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one dihydrochloride

Xylose Impurity 9

5-Bromo-2-chloro-N-cyclopentylamine-4-pyrimidine

733039-20-8

733039-20-6

73309-20-8

Anticancer

733039-20-8