ChemicalBook > CAS DataBase List > 4-Fluoro-7-nitrobenzofurazan

4-Fluoro-7-nitrobenzofurazan

Product Name
4-Fluoro-7-nitrobenzofurazan
CAS No.
29270-56-2
Chemical Name
4-Fluoro-7-nitrobenzofurazan
Synonyms
NBD-F;NBD FLUORIDE;4-Fluoro-7-nitro-2,1;4-FLUORO-7-NITROBENZOFURAZAN;4-FLUORO-7-NITROBENZOFUROZAN;4-Fluoro-7-nitrobenzofurazane;NITROBENZOFURAZAN, 4-FLUORO-7-;4-Fluoro-7-nitrobenzofurazan,98%;4-Fluoro-7-nitrobenzofurazan,NBD-F;NBD-F [4-Fluoro-7-nitrobenzofurazan
CBNumber
CB7255542
Molecular Formula
C6H2FN3O3
Formula Weight
183.1
MOL File
29270-56-2.mol
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4-Fluoro-7-nitrobenzofurazan Property

Melting point:
52-54 °C(lit.)
Boiling point:
308.6±45.0 °C(Predicted)
Density 
1.6753 (estimate)
Flash point:
>230 °F
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
It is soluble in DMSO, DMF, CH3OH, CH3CN and CHCl3.
pka
-5.59±0.50(Predicted)
form 
Crystalline Chunks
color 
Brown
BRN 
1077571
CAS DataBase Reference
29270-56-2(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/38
Safety Statements 
26-36-39
WGK Germany 
3
10-21
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
47140
Product name
4-Fluoro-7-nitrobenzofurazan
Purity
BioReagent, suitable for fluorescence, ≥98.0% (HPLC)
Packaging
10mg
Price
$470
Updated
2024/03/01
Sigma-Aldrich
Product number
47140
Product name
4-Fluoro-7-nitrobenzofurazan
Purity
BioReagent, suitable for fluorescence, ≥98.0% (HPLC)
Packaging
50mg
Price
$1920
Updated
2024/03/01
TCI Chemical
Product number
A5593
Product name
NBD-F (=4-Fluoro-7-nitro-2,1,3-benzoxadiazole)[for HPLC Labeling]
Purity
>99.0%(HPLC)
Packaging
100mg
Price
$228
Updated
2024/03/01
Alfa Aesar
Product number
J61336
Product name
4-Fluoro-7-nitrobenzofurazan
Packaging
100mg
Price
$508
Updated
2024/03/01
Sigma-Aldrich
Product number
F5883
Product name
4-Fluoro-7-nitrobenzofurazan
Purity
≥98% (elemental analysis)
Packaging
5mg
Price
$288
Updated
2024/03/01
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4-Fluoro-7-nitrobenzofurazan Chemical Properties,Usage,Production

Chemical Properties

BROWN CRYSTALLINE CHUNKS

Uses

A fluorescence reagent

Uses

4-Chloro-7-nitrobenzofurazan (NBD-chloride) was used in the following studies, Synthesis of fluorescent phospholipid-derivative, NBD-didecanoylphosphatidylethanolamine, Synthesis of functionalized hydroxynaphthofurazan, Spectrophotometric and spectrofluorometric determination of clemastine hydrogen fumarate, loratadine, losartan potassium and ramipril in pharmaceutical formulations. Synthesis of 7-nitrobenzofurazan (NBD)-labeled maleimide, via Diels-Alder reaction. NBD-Cl is widely used to label peptides, proteins, drugs and other biomolecules. It is also a popular derivatizing reagent for HPLC analysis

Purification Methods

Purify it by repeated recrystallisation from pet ether (b 40-60o). On treatment with MeONa in MeOH it gives 4-methoxy-7-nitrobenzo-2-oxa-1,3-diazole m 115-116o. [Nunno et al. J Chem Soc (C) 1433 1970.] It is a very good fluorophore for amino acids [Imai & Watanabe Analyt Chim Acta 130 377 1981], as it reacts with primary and secondary amines to form fluorescent adducts with 470nm and 530nm. It gives a glycine derivative with m 185-187o [Miyano et al. Anal Chim ex em Acta 170 81 1985]. 5-Fluorouracil (5 -fluoropyrimidinedi -2,4 -[1 H ,3 H ]-one) [51 -21 -8] M 130.1, m 282 -2 8 3o(dec), 282-286o(dec), pK 1 8.04, pK 2 13.0. Recrystallise it from H2O or MeOH/Et2O and sublime it at 190-200o/0.1mm or 210-230o/0.5mm. UV: at 265-266nm ( 7070). [Barton et al. J Org max Chem 37 329 1972, Duschinsky & Pleven J Am Chem Soc 79 4559 1957, Beilstein 24 III/IV 1229.]

4-Fluoro-7-nitrobenzofurazan Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Fluoro-7-nitrobenzofurazan Suppliers

Shanghai Join Biological Pharmaceutical Co., Ltd.
Tel
13818361018 13818361018
Fax
-
Email
shzuolin@163.com
Country
China
ProdList
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50
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
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Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
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TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
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24529
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Energy Chemical
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021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
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China
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Beijing Ouhe Technology Co., Ltd
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010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
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China
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12390
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Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9809
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Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
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50
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
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Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11707
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View Lastest Price from 4-Fluoro-7-nitrobenzofurazan manufacturers

R&D Scientific Inc.
Product
4-Fluoro-7-nitro-2,1,3-benzoxadiazole 29270-56-2
Price
US $4500.00/g
Min. Order
1g
Purity
97
Supply Ability
500 Kg
Release date
2024-08-23
Xian confluore Biological Technology Co., Ltd.
Product
4-fluoro-7-nitro-2,1,3-benzoxadiazole 29270-56-2
Price
US $0.00/g
Min. Order
1g
Purity
>95.00%
Supply Ability
1g
Release date
2024-04-01
Career Henan Chemical Co
Product
4-Fluoro-7-nitrobenzofurazan 29270-56-2
Price
US $2.00/kg
Min. Order
1kg
Purity
9%
Supply Ability
100kg
Release date
2018-12-23

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