CAY10505

Product Name: CAY10505
CAS No.: 1218777-13-9
Chemical Name: CAY10505
Synonyms: CAY10505;CAY10505, >=98%;CAY10505 CAY-10505;CAY10505 USP/EP/BP;(E)-5-((5-(4-fluorophenyl)furan-2-yl)methylene)thiazolidine-2,4-dione;(5E)-5-[[5-(4-Fluorophenyl)-2-furanyl]methylene]-2,4-thiazolidinedione;2,4-Thiazolidinedione, 5-[[5-(4-fluorophenyl)-2-furanyl]methylene]-, (5E)-;CAY10505 ( 5E)-5-[[5-(4-Fluorophenyl)-2-furanyl]methylene]-2,4-thiazolidinedione
CBNumber: CB72561463
Molecular Formula: C14H8FNO3S
Formula Weight: 289.28
MOL File: 1218777-13-9.mol

More

Less

CAY10505 Property

Density: 1.466
storage temp.: Store at -20°C
solubility: insoluble in EtOH; insoluble in H2O; ≥14.45 mg/mL in DMSO
form: solid
pka: 7.21±0.20(Predicted)
color: Light yellow to yellow

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

TRC

Product number: C226995
Product name: CAY10505
Packaging: 10mg
Price: $50
Updated: 2021/12/16

ChemScene

Product number: CS-5662
Product name: CAY10505
Purity: 99.79%
Packaging: 10mg
Price: $50
Updated: 2021/12/16

ApexBio Technology

Product number: B2182
Product name: CAY10505
Packaging: 25mg
Price: $70
Updated: 2021/12/16

ChemScene

Product number: CS-5662
Product name: CAY10505
Purity: 99.79%
Packaging: 25mg
Price: $90
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: KIN0001505
Product name: CAY-10505
Purity: 95.00%
Packaging: 1MG
Price: $135.45
Updated: 2021/12/16

More

Less

CAY10505 Chemical Properties,Usage,Production

Uses

CAY10505 is a phosphoinositide 3-kinase gamma (PI3Kγ) specific inhibitor and improves hypertension-associated vascular endothelial dysfunction.

Biological Activity

cay10505 is a potent and selective pi3kγ inhibitor (ic50= 30 nm)pi3k (phosphatidylinositol-4,5-bisphosphate 3-kinase) is a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer. it plays a key role in pi3k/akt/mtor pathway.in neurons treated with 3.5 μm ba, 200 nm cay10505 partially reduced the baicalein-induced akt phosphorylation. [1]in hypertensive rats, cay10505 at 0.6 mg.kg-1 p.o. exhibited the following effects 1) effectively reduced mabp; 2) significantly ameliorated vascular endothelium dysfunction in hypertensive rats in combination of doca; 3) prominently increased serum nitrite and/or nitrate concentrations.4) prevented hypertension-induced attenuation of ach-induced endothelium-dependent relaxation.[2]

References

[1] tyagi s, sharma s, budhiraja rd. effect of phosphatidylinositol 3-kinase-γ inhibitor cay10505 in hypertension, and its associated vascular endothelium dysfunction in rats. can j physiol pharmacol. 2012 jul;90(7):881-5.
[2] sun yy, lin sh, lin hc et al. cell type-specific dependency on the pi3k/akt signaling pathway for the endogenous epo and vegf induction by baicalein in neurons versus astrocytes. plos one. 2013 jul 19;8(7):e69019.

CAY10505 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

CAY10505 Suppliers

China 69 India 1 United States 14 Global 84

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
Advantage: 58

Target molecule Corp.

Tel: 857-239-0968
Fax: 857-239-8801
Email: service1@targetmol.com
Country: United States
ProdList: 2559
Advantage: 60

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32165
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

TargetMol Chemicals Inc.

Tel
Email: support@targetmol.com
Country: United States
ProdList: 38632
Advantage: 58

ApexBio Technology

Tel: --
Fax: --
Email: sales@apexbt.com
Country: United States
ProdList: 6251
Advantage: 58

Santa Cruz Biotechnology, Inc.

Tel: --
Fax: --
Email: scbt@scbt.com
Country: United States
ProdList: 3597
Advantage: 60

Selleck Chemicals LLC

Tel: --
Fax: --
Email: info@selleckchem.com
Country: United States
ProdList: 824
Advantage: 60

United States Biological

Tel: --
Fax: --
Email: chemicals@usbio.net
Country: United States
ProdList: 6214
Advantage: 80

Creative Enzymes

Tel: --
Fax: --
Email: info@creative-enzymes.com
Country: United States
ProdList: 6057
Advantage: 58

MedChemExpress

Tel: --
Fax: --
Email: sales@medchemexpress.com
Country: United States
ProdList: 6398
Advantage: 58

LKT Laboratories, Inc.

Tel: --
Fax: --
Email: info@lktlabs.com
Country: United States
ProdList: 2164
Advantage: 64

More

Less

View Lastest Price from CAY10505 manufacturers

Career Henan Chemical Co

Product: (5E)-5-[[5-(4-fluorophenyl)furan-2-yl]methylidene]-1,3-thiazolidine-2,4-dione 1218777-13-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2019-12-20

1218777-13-9, CAY10505Related Search:

Benzamide, 4-(dimethylamino)-N-[3-[[2-[(4-oxo-4H-1-benzopyran-7-yl)oxy]acetyl]amino]phenyl]- 6-[4-(1H-IMIDAZOL-1-YL)PHENOXY]-N,N-DIMETHYL-1-HEXANAMINE, DIHYDROCHLORIDE I-BET151 (GSK1210151A) MK-1775 BKM120 (NVP-BKM120, Buparlisib) Selumetinib PF-562271 SGX-523

CAY10505

(5E)-5-[[5-(4-Fluorophenyl)-2-furanyl]methylene]-2,4-thiazolidinedione

(E)-5-((5-(4-fluorophenyl)furan-2-yl)methylene)thiazolidine-2,4-dione

CAY10505 ( 5E)-5-[[5-(4-Fluorophenyl)-2-furanyl]methylene]-2,4-thiazolidinedione

CAY10505, >=98%

2,4-Thiazolidinedione, 5-[[5-(4-fluorophenyl)-2-furanyl]methylene]-, (5E)-

CAY10505 USP/EP/BP

CAY10505 CAY-10505

1218777-13-9

Akt

mTOR

PI3K

PI3K/Akt/mTOR

Inhibitors