ChemicalBook > CAS DataBase List > SMER 3

SMER 3

Product Name
SMER 3
CAS No.
67200-34-4
Chemical Name
SMER 3
Synonyms
SMER 3;SMER3(SMER 3);5-oxoinden[1,2-e]furazano[3,4-b]pyrazine;9H-indeno[2,1-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one;9H-Indeno[1,2-e][1,2,5]oxadiazolo[3,4-b]pyrazin-9-one;9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one N;OC1181, 9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one;Ubiquitin activating enzyme,SMER-3,SCF,E1/E2/E3 Enzyme,SMER3,anticancer,MET,Skp1,E1 activating enzyme,ligase,Inhibitor,Cullin,E2 conjugating enzyme,ubiquitin,Ubiquitin conjugating enzyme,Ubiquitin ligase,E3 ligating enzyme,inhibit
CBNumber
CB72565931
Molecular Formula
C11H4N4O2
Formula Weight
224.18
MOL File
67200-34-4.mol
More
Less

SMER 3 Property

Melting point:
283-284 °C(Solv: ethanol (64-17-5))
Boiling point:
437.2±55.0 °C(Predicted)
Density 
1.665±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: ≥30mg/mL
pka
-8.15±0.20(Predicted)
form 
powder
color 
yellow
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
More
Less

Safety

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
1
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S7826
Product name
SMER3
Purity
≥98% (HPLC)
Packaging
5mg
Price
$113
Updated
2024/03/01
Sigma-Aldrich
Product number
S7826
Product name
SMER3
Purity
≥98% (HPLC)
Packaging
25mg
Price
$436
Updated
2024/03/01
Cayman Chemical
Product number
15324
Product name
SMER3
Purity
≥95%
Packaging
5mg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
15324
Product name
SMER3
Purity
≥95%
Packaging
10mg
Price
$120
Updated
2024/03/01
Cayman Chemical
Product number
15324
Product name
SMER3
Purity
≥95%
Packaging
25mg
Price
$199
Updated
2024/03/01
More
Less

SMER 3 Chemical Properties,Usage,Production

Description

SMER3 is a selective inhibitor of Skp1-Cullin-F-box (SCF)MET30 ubiquitin ligase, an E3 ligase that regulates transcription, cell-cycle control, and immune response. It is a small molecule enhancer of rapamycin , in that it enhances yeast cell lethality in response to rapamycin. SMER3, at 5 μM, upregulates a set of methionine biosynthesis genes by altering the SCFMET30 complex, preventing ubiquitination of target proteins, including Met4. As ubiquitin E3 ligases are involved in tumorigenesis, SMER3 has potential applications in cancer research.

Uses

SMER3 is used in biological studies to evaluate the pharmacological activity as it is discovered as an inhibitor. SMER3 inhibits mTOR (mammalian target of rapamycin) which plays a key role in the growth control in eukaryotic cells. SMER is the small-molecule enhancer of rapamycin.

Definition

ChEBI: LSM-42773 is an aromatic ketone.

storage

Store at +4°C

References

1) Aghajanyy et al. (2010), Chemical genetics of TOR identifies an SCF family E3 ubiquitin ligase inhibitor; Nat. Biotechnol., 28 738

SMER 3 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

SMER 3 Suppliers

China 56 Europe 1 Japan 1 United Kingdom 1 United States 11 Global 70
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
14055
Advantage
65
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32165
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
United States Biological
Tel
--
Fax
--
Email
sales@advtechind.com
Country
United States
ProdList
6075
Advantage
58
ApexBio Technology
Tel
--
Fax
--
Email
sales@apexbt.com
Country
United States
ProdList
6251
Advantage
58
Focus Biomolecules
Tel
--
Fax
--
Email
sales@focusbiomolecules.com
Country
United States
ProdList
1284
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
Creative Enzymes
Tel
--
Fax
--
Email
info@creative-enzymes.com
Country
United States
ProdList
6057
Advantage
58
Axon Medchem LLC
Tel
--
Fax
--
Email
info@axonmedchem.com
Country
United States
ProdList
763
Advantage
58
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87

67200-34-4, SMER 3Related Search:

P-5091 Pevonedistat MG-132 TOS-ARG-OME HCL

  • SMER 3
  • 9H-Indeno[1,2-e][1,2,5]oxadiazolo[3,4-b]pyrazin-9-one
  • 9H-indeno[2,1-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one
  • OC1181, 9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one
  • SMER3(SMER 3)
  • 9H-indeno[1,2-b][1,2,5]oxadiazolo[3,4-e]pyrazin-9-one N
  • 5-oxoinden[1,2-e]furazano[3,4-b]pyrazine
  • Ubiquitin activating enzyme,SMER-3,SCF,E1/E2/E3 Enzyme,SMER3,anticancer,MET,Skp1,E1 activating enzyme,ligase,Inhibitor,Cullin,E2 conjugating enzyme,ubiquitin,Ubiquitin conjugating enzyme,Ubiquitin ligase,E3 ligating enzyme,inhibit
  • 67200-34-4
  • C11H4N4O2