ChemicalBook > CAS DataBase List > (S)-MEPHENYTOIN

(S)-MEPHENYTOIN

Product Name: (S)-MEPHENYTOIN
CAS No.: 70989-04-7
Chemical Name: (S)-MEPHENYTOIN
Synonyms: Mephenitoin S;(S)-MEPHENYTOIN;(S)-Mephenitoin;(S)-Mephenytoine;(S)-(+)-MEPHENYTOIN;Mephenytoin Impurity 2;(S)-Mephenytoin - Bio-X ?;(S)-Mephenytoin, 10 mM in DMSO;(S)-5-ETHYL-3-METHYL-5-PHENYLHYDANTOIN;(5S)-5-Ethyl-3-methyl-5-phenylhydantoin
CBNumber: CB7257425
Molecular Formula: C12H14N2O2
Formula Weight: 218.25
MOL File: 70989-04-7.mol

Less

(S)-MEPHENYTOIN Property

Melting point:: 135-138 °C
Density: 1.154±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble
pka: 8.07±0.70(Predicted)
form: solid
color: off-white

Less

Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 26-36
WGK Germany: 2
HS Code: 29332100

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: UC175
Product name: (S)-(+)-Mephenytoin
Purity: solid, ≥98% (HPLC)
Packaging: 5mg
Price: $876.85
Updated: 2025/07/31

Sigma-Aldrich

Product number: UC175
Product name: (S)-(+)-Mephenytoin
Purity: solid, ≥98% (HPLC)
Packaging: 10mg
Price: $1610
Updated: 2025/07/31

Cayman Chemical

Product number: 11913
Product name: (S)-Mephenytoin
Purity: ≥98%
Packaging: 1mg
Price: $39
Updated: 2024/03/01

Cayman Chemical

Product number: 11913
Product name: (S)-Mephenytoin
Purity: ≥98%
Packaging: 5mg
Price: $96
Updated: 2024/03/01

Cayman Chemical

Product number: 11913
Product name: (S)-Mephenytoin
Purity: ≥98%
Packaging: 10mg
Price: $173
Updated: 2024/03/01

Less

(S)-MEPHENYTOIN Chemical Properties,Usage,Production

Chemical Properties

White Crystalline Solid

Uses

S-Mephenytoin has been used as a CYP2C19 substrate for the analysis of cytochrome P450 metabolism. S-Mephenytoin has also been used as probe substrates for LC/MS-based analysis of relative activity factor (RAF).

Uses

(S)-Mephenytoin can be used as an anticonvulsant agent.

Definition

ChEBI: (S)-Mephenytoin is an imidazolidine-2,4-dione.

Biological Activity

(s)-mephenytoin is an anticonvulsive drug which is metabolized by n-demethylation and 4-hydroxylation (of the aromatic ring). (s)-mephenytoin is a substrate of the cytochrome p450 (cyp) isoform cyp2c19, also known as mephenytoin 4-hydroxylase [1].cyp2c19 is the main mephenytoin 4-hydroxylase in humans implicated in metabolizing a variety of therapeutic agents, such as omeprazole, proguanil, diazepam, propranolol, citalopram, imipramine, and certain barbiturates [2].

Biochem/physiol Actions

CYP2B6 & CYP2C19 substrate. Methenytoin isomer. Anticonvulsant; antiepileptic.

in vitro

in the presence of cytochrome b5, the km value for s-mephenytoin was 1.25 mm with all five purified cytochrome p-450s preparations, and vmax values were 0.8-1.25 nmol of 4-hydroxy product formed per min/nmol of p-450 [1].

References

[1] shimada t, misono k s, guengerich f p. human liver microsomal cytochrome p-450 mephenytoin 4-hydroxylase, a prototype of genetic polymorphism in oxidative drug metabolism. purification and characterization of two similar forms involved in the reaction[j]. journal of biological chemistry, 1986, 261(2): 909-921.
[2] ferguson r j, de morais s m f, benhamou s, et al. a new genetic defect in human cyp2c19: mutation of the initiation codon is responsible for poor metabolism of s-mephenytoin[j]. journal of pharmacology and experimental therapeutics, 1998, 284(1): 356-361.

(S)-MEPHENYTOIN Preparation Products And Raw materials

Raw materials

Preparation Products

Less

(S)-MEPHENYTOIN Suppliers

Canada 1 China 95 France 1 Germany 1 India 3 Switzerland 1 Ukraine 1 United Kingdom 1 United States 17 Global 121

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12984
Advantage: 57

Spectrum Chemical Manufacturing Corp.

Tel: 021-021-021-67601398-809-809-809 15221380277
Fax: 021-57711696
Email: marketing_china@spectrumchemical.com
Country: China
ProdList: 9658
Advantage: 60

Hangzhou Sage Chemical Co., Ltd.

Tel: +86057186818502 13588463833
Fax: Pls mail us for more information!
Email: info@sagechem.com
Country: China
ProdList: 10266
Advantage: 58

Shanghai Macklin Biochemical Co.,Ltd.

Tel: 15221275939
Fax: 021-50706099
Email: shenlinxing@macklin.cn
Country: China
ProdList: 15873
Advantage: 55

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51395
Advantage: 80

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Aikon International Limited

Tel: 025-58859352 18068836627
Fax: (5)02557626880
Email: dt3@aikonchem.com
Country: China
ProdList: 15493
Advantage: 58

Jinan Feiteng Pharmaceutical Technology Co., Ltd.

Tel: 15589964716
Fax: qq：3360232875
Email: 15253102672@163.com
Country: China
ProdList: 211
Advantage: 58

Beijing OKA biological technology co., LTD

Tel: 010-62971590 18548936886
Fax: 010-62340519
Email: 3462612863@qq.com
Country: China
ProdList: 10063
Advantage: 58

Beijing Minruida Technology Co., Ltd.

Tel: 010-82387566 18001021521;
Fax: 82387566-801
Email: sales@mreda.com.cn
Country: China
ProdList: 10083
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57422
Advantage: 58

TOSUN PHARM

Tel: 020-61855200 13326451905
Email: 260366801@qq.com
Country: China
ProdList: 7924
Advantage: 58

Wuhan chuang he chemical co. LTD

Tel: 15907120073
Fax: 15527109962
Email: 1261789306@qq.com
Country: China
ProdList: 1312
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49975
Advantage: 58

SHENZHEN PHYSTANDARD BIO-TECH CO.,LTD

Tel: 0755-0755-83725350 13380397412
Fax: 0755-28094224
Email: 3001280422@qq.com
Country: China
ProdList: 10001
Advantage: 58

MedBioPharmaceutical Technology Inc

Tel: 021-69568360 18916172912
Email: order@med-bio.cn
Country: China
ProdList: 8140
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

Wuhan Topule

Tel: +86-02787215551 +86-19945035818
Fax: 027-87215551
Email: 2936752263@qq.com
Country: China
ProdList: 7986
Advantage: 58

cjbscvictory

Tel: 13348960310
Email: 3003867561@qq.com
Country: China
ProdList: 10503
Advantage: 58

Shanghai Sunway Pharmaceutical Technology Co.,Ltd.

Tel: 021-51816796-820 13611835272
Fax: 021-5161 3951
Email: sales2@sunwaypharm.com
Country: China
ProdList: 44119
Advantage: 58

Hubei yongkuo Technology Co., Ltd

Tel: 027-027-59223108 15972152991
Fax: 027-59223108
Email: 1248580099@qq.com
Country: China
ProdList: 9953
Advantage: 58

Hubei Xinkang Pharmaceutical Chemical Co., Ltd

Tel: 027-027-59308705 18871579363
Fax: 027-59308705
Email: 1248680011@qq.com
Country: China
ProdList: 9850
Advantage: 58

Hubei Shishun Biotechnology Co. Ltd

Tel: 027-027-59223025 15107168801
Fax: 027-59223025
Email: 1718480011@qq.com
Country: China
ProdList: 9719
Advantage: 58

Hubei Baidu Chemical Co., Ltd

Tel: 027-027-59106051 13627137652
Fax: 027-59223020
Email: 1438180055@qq.com
Country: China
ProdList: 8750
Advantage: 58

Hubei Guangao Biotechnology Co., Ltd

Tel: 027-02702759223056 18162699093
Fax: 027-59223056
Email: 1208480011@qq.com
Country: China
ProdList: 9875
Advantage: 58

Hubei Wande Chemical Co., Ltd

Tel: 027-027-59210159 15377098680
Fax: 027-59210159
Email: 1148280011@qq.com
Country: China
ProdList: 9835
Advantage: 58

Tianmen Hengchang Chemical Co., Ltd

Tel: 027-027-59322316 15172518801
Fax: 027-59322316
Email: 1208480077@qq.com
Country: China
ProdList: 9850
Advantage: 58

Hubei Qifei Pharmaceutical Chemical Co., Ltd

Tel: 027-59322506 18071128681
Fax: 027-59322506
Email: 1438082200@qq.com
Country: China
ProdList: 9921
Advantage: 58

Hubei xingongli Chemical Co., Ltd

Tel: 027-027-59106151 15172325309
Fax: 027-59503710
Email: 1400858877@qq.com
Country: China
ProdList: 9928
Advantage: 58

TCI (Shanghai) Chemical Trading Co., Ltd.

Tel: 021-61109150
Fax: 021-61105897
Email: sales@tcisct.com
Country: China
ProdList: 29668
Advantage: 58

Nantong Hi-Future Biotechnology Co., Ltd

Tel: 18051384581
Email: sales@chemhifuture.com
Country: China
ProdList: 2998
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 15801484223;
Email: psaitong@jm-bio.com
Country: China
ProdList: 29757
Advantage: 58

Hubei Yunmei Technology Co., Ltd

Tel: 027-59206672 18327059871
Email: service@yunmeichem.com
Country: China
ProdList: 4955
Advantage: 58

Shanghai Universal Biotech Co.,Ltd

Tel: 15921930842 15921930842
Email: yh-wang@univ-bio.com
Country: China
ProdList: 25004
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 59936
Advantage: 58

JiangSu Star Science Co.,Ltd

Tel: 400-605-7200 15335295587
Email: 3941881028@qq.com
Country: China
ProdList: 3760
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

LGC Science (Shanghai) Ltd.

Tel: 17717235263
Email: cindy.yang@lgcgroup.com
Country: China
ProdList: 18003
Advantage: 58

Xianning Shen Lan Biomedical Research and Development Co., Ltd.

Tel: 18171815831
Email: 1341138380@qq.com
Country: China
ProdList: 4310
Advantage: 58

Hubei DAHAO Chemical Co., Ltd.

Tel: 027-027-59106191 13986034860
Email: 1400828855@qq.com
Country: China
ProdList: 8919
Advantage: 58

Hubei Tuobang Chemical Co., Ltd.

Tel: 13986192185 13986192185
Email: 1466039@qq.com
Country: China
ProdList: 9894
Advantage: 58

Guangdong Fangxin Biotechnology Co., Ltd.

Tel: 0751-2838688 13376594225
Email: 1276075424@qq.com
Country: China
ProdList: 9942
Advantage: 58

Shanghai Yingxin laboratory equipment Co., Ltd

Tel: 021-021-59178156 15300768757
Email: 359382369@qq.com
Country: China
ProdList: 10674
Advantage: 58

Xuchang Fengfei New Materials Technology Co., Ltd

Tel: 19713077352
Email: 1038096457@qq.com
Country: China
ProdList: 2640
Advantage: 58

Shanghai Guchen Biotechnology Co., LTD

Tel: 021-34675735 19147740836
Email: 1986399151@qq.com
Country: China
ProdList: 9844
Advantage: 58

70989-04-7, (S)-MEPHENYTOINRelated Search:

4-HYDROXY MEPHENYTOIN 4-HYDROXY MEPHENYTOIN-D3 (R)-MEPHENYTOIN,(R)-(-)-MEPHENYTOIN (S)-MEPHENYTOIN H-PHG-NH2 HCL (S)-MEPHENYTOIN,(S)-(+)-MEPHENYTOIN,MEPHENYTOIN,(+/-)-MEPHENYTOIN,DL-Mephenytoin 2-PHENYLBUTYRYLUREA 7,8-DIHYDROXY-6-METHOXYCOUMARIN 5-Phenylhydantoin S-(+)-N-Desmethyl Mephenytoin (S)-(+)-N-3-Benzylnirvanol 1,2-Ethanediamine,N2,N2-dimethyl-1-phenyl-,(1S)-(9CI) rac N-Desmethyl Mephenytoin-deuterated,rac N-Desmethyl Mephenytoin-D5 (Major) RAC MEPHENYTOIN-D3 N-DESMETHYL MEPHENYTOIN-D5 DESMETHYL MEPHENYTOIN,rac N-Desmethyl Mephenytoin rac Mephenytoin-D5 MEPHENYTOIN USP(CRM STANDARD)

(S)-(+)-5-Ethyl-3-methyl-5-phenyl-2,4-imidazolidinedione, (S)-(+)-5-Ethyl-3-methyl-5-phenylhydantoin

(5S)-5-Ethyl-3-methyl-5-phenylhydantoin

(5S)-5β-Ethyl-3-methyl-5-phenylhydantoin

Mephenitoin S

(5S)-5-ethyl-3-methyl-5-phenyl-imidazolidine-2,4-dione

(5S)-5-ethyl-3-methyl-5-phenylimidazolidine-2,4-dione

(S)-(+)-MEPHENYTOIN

(S)-(+)-5-ETHYL-3-METHYL-5-PHENYL-2,4-IMIDAZOLIDINEDIONE

(S)-(+)-5-ETHYL-3-METHYL-5-PHENYLHYDANTOIN

(S)-5-ETHYL-3-METHYL-5-PHENYLHYDANTOIN

(5S)-5-Ethyl-3-Methyl-5-phenyl-2,4-iMidazolidinedione

2,4-IMidazolidinedione, 5-ethyl-3-Methyl-5-phenyl-, (5S)-

(S)-5-ethyl-3-Methyl-5-phenyliMidazolidine-2,4-dione

(S)-Mephenytoine

(S)-MEPHENYTOIN

Mephenytoin Impurity 2

(S)-Mephenitoin

inhibit,(+)-Mephenytoin,cytochrome,Inhibitor,(S)Mephenytoin,CYP2C19,(S) Mephenytoin,P450,(S)-Mephenytoin,anticonvulsive

(S)-(+)-Mephenytoin solid, >=98% (HPLC)

(S)-Mephenytoin, 10 mM in DMSO

(S)-Mephenytoin - Bio-X ?

70989-04-7

Hydantoins and Derivatives

Hydantoins & Derivatives

Intermediates & Fine Chemicals

Pharmaceuticals

Heterocycles