7,8-DIHYDROXY-6-METHOXYCOUMARIN

Product Name: 7,8-DIHYDROXY-6-METHOXYCOUMARIN
CAS No.: 574-84-5
Chemical Name: 7,8-DIHYDROXY-6-METHOXYCOUMARIN
Synonyms: FRAXETIN;Fraxetol;Fratexin;Fraccetain;Fraxetin-RM;Einecs 209-376-2;Fraxetin (6-OMe, 7,8-OH);7,8-DIHYDROXY-6-METHOXYCOUMARIN;Coumarin, 7,8-dihydroxy-6-methoxy-;7,8-Dihydroxy-6-MethoxycouMarin 98%
CBNumber: CB9110595
Molecular Formula: C10H8O5
Formula Weight: 208.17
MOL File: 574-84-5.mol

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7,8-DIHYDROXY-6-METHOXYCOUMARIN Property

Melting point:: 230-231 °C (lit.)
Boiling point:: 307.35°C (rough estimate)
Density: 1.3844 (rough estimate)
refractive index: 1.4717 (estimate)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMSO : 250 mg/mL (1200.94 mM; Need ultrasonic)
pka: 7.22±0.20(Predicted)
form: Solid
color: White
Merck: 13,4288
Stability:: Hygroscopic
InChI: InChI=1S/C10H8O5/c1-14-6-4-5-2-3-7(11)15-10(5)9(13)8(6)12/h2-4,12-13H,1H3
InChIKey: HAVWRBANWNTOJX-UHFFFAOYSA-N
SMILES: C1(=O)OC2=C(O)C(O)=C(OC)C=C2C=C1
LogP: 0.590 (est)
CAS DataBase Reference: 574-84-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22-36/37/38
Safety Statements: 26-36
WGK Germany: 3
HS Code: 29322090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 254916
Product name: 7,8-Dihydroxy-6-methoxycoumarin
Purity: 98%
Packaging: 250mg
Price: $504
Updated: 2025/07/31

Sigma-Aldrich

Product number: 18224
Product name: Fraxetin
Purity: analytical standard
Packaging: 50mg
Price: $248
Updated: 2022/05/15

Cayman Chemical

Product number: 28011
Product name: Fraxetin
Packaging: 10mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 28011
Product name: Fraxetin
Packaging: 100mg
Price: $419
Updated: 2024/03/01

Cayman Chemical

Product number: 28011
Product name: Fraxetin
Packaging: 25mg
Price: $135
Updated: 2024/03/01

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7,8-DIHYDROXY-6-METHOXYCOUMARIN Chemical Properties,Usage,Production

Chemical Properties

Pale yellow crystalline powder, easily soluble in methanol and acetone, derived from the bark of Fraxinus chinensis, the bark of Fraxinus microphylla, and the leaves of Fraxinus himachicola.

Uses

Fraxetin is a coumarin compound with anti-oxidant and anti-inflammatory activity. Also acts as a protective agent against hyperuricemia and renal dysfunction.

Definition

ChEBI: Fraxetin is a hydroxycoumarin that is 6-methoxycoumarin in which the hydrogens at positions 7 and 8 have been replaced by hydroxy groups. It has a role as an Arabidopsis thaliana metabolite, an antimicrobial agent, an apoptosis inhibitor, an apoptosis inducer, an antioxidant, an anti-inflammatory agent, a hepatoprotective agent, an antibacterial agent and a hypoglycemic agent. It is a hydroxycoumarin and an aromatic ether.

in vivo

Fraxetin (20-50 mg/kg, gavage, once daily, 24 weeks) has a hepatoprotective effect in mice and also has antioxidant and anti-inflammatory activities^[3].

Animal Model:	Ethanol-induced liver fibrosis model in rats ^[3]
Dosage:	20, 50 mg/kg; daily; 24 weeks
Administration:	i.g.
Result:	Reduced serum ALT and AST, weakened tissue pathological changes, upregulated heme oxygenase-1 (HO-1) protein, reduced lipid peroxidation, enhanced liver antioxidant capacity, inhibited CYP2E1 activity, and reduced inflammatory mediators such as TNF-α and IL-1β.

7,8-DIHYDROXY-6-METHOXYCOUMARIN Preparation Products And Raw materials

Raw materials

Preparation Products

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7,8-DIHYDROXY-6-METHOXYCOUMARIN Suppliers

China 243 Finland 1 France 2 Germany 5 India 2 Switzerland 2 United Kingdom 6 United States 22 Global 283

Nanjing Bencao Yikang Biotechnology Co., Ltd

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Dalian Meilun Biotech Co., Ltd.

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BioBioPha Co., Ltd.

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View Lastest Price from 7,8-DIHYDROXY-6-METHOXYCOUMARIN manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Fraxetin 574-84-5
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2019-09-17

Shanghai Standard Technology Co., Ltd.

Product: Fraxetin 574-84-5
Price: US $0.00/mg
Min. Order: 5mg
Purity: Analytical Standard
Supply Ability: 10 g
Release date: 2019-09-17

Dideu Industries Group Limited

Product: 7,8-DIHYDROXY-6-METHOXYCOUMARIN 574-84-5
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-10-29

574-84-5, 7,8-DIHYDROXY-6-METHOXYCOUMARINRelated Search:

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Fraxetin (6-OMe, 7,8-OH)

7,8-Dihydroxy-6-MethoxycouMarin 98%

2H-1-Benzopyran-2-one, 7,8-dihydroxy-6-methoxy-

7,8-Dihydroxy-6-methoxy-2H-chromen-2-one

7,8-DIHYDROXY-6-METHOXYCOUMARIN

Fratexin

FRAXETIN

7,8-dihydroxy-6-methoxy-2-benzopyrone

7,8-dihydroxy-6-methoxychromen-2-one

7,8-Dihydroxy-6-methoxy-2H-1-benzopyran-2-one

Fraccetain

Fraxetol

7,8-Dihydroxy-6-methoxycoumarin,Fraxetin

Coumarin, 7,8-dihydroxy-6-methoxy-

Einecs 209-376-2

7,8-DIHYDROXY-6-METHOXYCOUMARIN ISO 9001：2015 REACH

Fraxetin-RM

574-84-5

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

Inhibitors

Coumarins