ChemicalBook > CAS DataBase List > 7,8-DIHYDROXY-6-METHOXYCOUMARIN

7,8-DIHYDROXY-6-METHOXYCOUMARIN

Product Name
7,8-DIHYDROXY-6-METHOXYCOUMARIN
CAS No.
574-84-5
Chemical Name
7,8-DIHYDROXY-6-METHOXYCOUMARIN
Synonyms
FRAXETIN;Fraxetol;Fratexin;Fraccetain;Fraxetin-RM;Einecs 209-376-2;Fraxetin (6-OMe, 7,8-OH);7,8-DIHYDROXY-6-METHOXYCOUMARIN;Coumarin, 7,8-dihydroxy-6-methoxy-;7,8-Dihydroxy-6-MethoxycouMarin 98%
CBNumber
CB9110595
Molecular Formula
C10H8O5
Formula Weight
208.17
MOL File
574-84-5.mol
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7,8-DIHYDROXY-6-METHOXYCOUMARIN Property

Melting point:
230-231 °C (lit.)
Boiling point:
307.35°C (rough estimate)
Density 
1.3844 (rough estimate)
refractive index 
1.4717 (estimate)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
DMSO : 250 mg/mL (1200.94 mM; Need ultrasonic)
pka
7.22±0.20(Predicted)
form 
Solid
color 
White
Merck 
13,4288
Stability:
Hygroscopic
InChI
InChI=1S/C10H8O5/c1-14-6-4-5-2-3-7(11)15-10(5)9(13)8(6)12/h2-4,12-13H,1H3
InChIKey
HAVWRBANWNTOJX-UHFFFAOYSA-N
SMILES
C1(=O)OC2=C(O)C(O)=C(OC)C=C2C=C1
LogP
0.590 (est)
CAS DataBase Reference
574-84-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22-36/37/38
Safety Statements 
26-36
WGK Germany 
3
HS Code 
29322090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
254916
Product name
7,8-Dihydroxy-6-methoxycoumarin
Purity
98%
Packaging
250mg
Price
$504
Updated
2025/07/31
Sigma-Aldrich
Product number
18224
Product name
Fraxetin
Purity
analytical standard
Packaging
50mg
Price
$248
Updated
2022/05/15
Cayman Chemical
Product number
28011
Product name
Fraxetin
Packaging
10mg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
28011
Product name
Fraxetin
Packaging
100mg
Price
$419
Updated
2024/03/01
Cayman Chemical
Product number
28011
Product name
Fraxetin
Packaging
25mg
Price
$135
Updated
2024/03/01
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7,8-DIHYDROXY-6-METHOXYCOUMARIN Chemical Properties,Usage,Production

Chemical Properties

Pale yellow crystalline powder, easily soluble in methanol and acetone, derived from the bark of Fraxinus chinensis, the bark of Fraxinus microphylla, and the leaves of Fraxinus himachicola.

Uses

Fraxetin is a coumarin compound with anti-oxidant and anti-inflammatory activity. Also acts as a protective agent against hyperuricemia and renal dysfunction.

Definition

ChEBI: Fraxetin is a hydroxycoumarin that is 6-methoxycoumarin in which the hydrogens at positions 7 and 8 have been replaced by hydroxy groups. It has a role as an Arabidopsis thaliana metabolite, an antimicrobial agent, an apoptosis inhibitor, an apoptosis inducer, an antioxidant, an anti-inflammatory agent, a hepatoprotective agent, an antibacterial agent and a hypoglycemic agent. It is a hydroxycoumarin and an aromatic ether.

in vivo

Fraxetin (20-50 mg/kg, gavage, once daily, 24 weeks) has a hepatoprotective effect in mice and also has antioxidant and anti-inflammatory activities[3].

Animal Model:Ethanol-induced liver fibrosis model in rats [3]
Dosage:20, 50 mg/kg; daily; 24 weeks
Administration:i.g.
Result:Reduced serum ALT and AST, weakened tissue pathological changes, upregulated heme oxygenase-1 (HO-1) protein, reduced lipid peroxidation, enhanced liver antioxidant capacity, inhibited CYP2E1 activity, and reduced inflammatory mediators such as TNF-α and IL-1β.

7,8-DIHYDROXY-6-METHOXYCOUMARIN Preparation Products And Raw materials

Raw materials

Preparation Products

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7,8-DIHYDROXY-6-METHOXYCOUMARIN Suppliers

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View Lastest Price from 7,8-DIHYDROXY-6-METHOXYCOUMARIN manufacturers

Shanghai Standard Technology Co., Ltd.
Product
Fraxetin 574-84-5
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2019-09-17
Shanghai Standard Technology Co., Ltd.
Product
Fraxetin 574-84-5
Price
US $0.00/mg
Min. Order
5mg
Purity
Analytical Standard
Supply Ability
10 g
Release date
2019-09-17
Dideu Industries Group Limited
Product
7,8-DIHYDROXY-6-METHOXYCOUMARIN 574-84-5
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-10-29

574-84-5, 7,8-DIHYDROXY-6-METHOXYCOUMARINRelated Search:

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  • Coumarin, 7,8-dihydroxy-6-methoxy-
  • Einecs 209-376-2
  • 7,8-DIHYDROXY-6-METHOXYCOUMARIN ISO 9001：2015 REACH
  • Fraxetin-RM
  • 574-84-5
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • Inhibitors
  • Coumarins