7,8-DIHYDROXY-6-METHOXYCOUMARIN
- Product Name
- 7,8-DIHYDROXY-6-METHOXYCOUMARIN
- CAS No.
- 574-84-5
- Chemical Name
- 7,8-DIHYDROXY-6-METHOXYCOUMARIN
- Synonyms
- FRAXETIN;Fraxetol;Fratexin;Fraccetain;Fraxetin-RM;Einecs 209-376-2;Fraxetin (6-OMe, 7,8-OH);7,8-DIHYDROXY-6-METHOXYCOUMARIN;Coumarin, 7,8-dihydroxy-6-methoxy-;7,8-Dihydroxy-6-MethoxycouMarin 98%
- CBNumber
- CB9110595
- Molecular Formula
- C10H8O5
- Formula Weight
- 208.17
- MOL File
- 574-84-5.mol
7,8-DIHYDROXY-6-METHOXYCOUMARIN Property
- Melting point:
- 230-231 °C (lit.)
- Boiling point:
- 307.35°C (rough estimate)
- Density
- 1.3844 (rough estimate)
- refractive index
- 1.4717 (estimate)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- DMSO : 250 mg/mL (1200.94 mM; Need ultrasonic)
- pka
- 7.22±0.20(Predicted)
- form
- Solid
- color
- White
- Merck
- 13,4288
- Stability:
- Hygroscopic
- InChI
- InChI=1S/C10H8O5/c1-14-6-4-5-2-3-7(11)15-10(5)9(13)8(6)12/h2-4,12-13H,1H3
- InChIKey
- HAVWRBANWNTOJX-UHFFFAOYSA-N
- SMILES
- C1(=O)OC2=C(O)C(O)=C(OC)C=C2C=C1
- LogP
- 0.590 (est)
- CAS DataBase Reference
- 574-84-5(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 26-36
- WGK Germany
- 3
- HS Code
- 29322090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 254916
- Product name
- 7,8-Dihydroxy-6-methoxycoumarin
- Purity
- 98%
- Packaging
- 250mg
- Price
- $504
- Updated
- 2025/07/31
- Product number
- 18224
- Product name
- Fraxetin
- Purity
- analytical standard
- Packaging
- 50mg
- Price
- $248
- Updated
- 2022/05/15
- Product number
- 28011
- Product name
- Fraxetin
- Packaging
- 10mg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 28011
- Product name
- Fraxetin
- Packaging
- 100mg
- Price
- $419
- Updated
- 2024/03/01
- Product number
- 28011
- Product name
- Fraxetin
- Packaging
- 25mg
- Price
- $135
- Updated
- 2024/03/01
7,8-DIHYDROXY-6-METHOXYCOUMARIN Chemical Properties,Usage,Production
Chemical Properties
Pale yellow crystalline powder, easily soluble in methanol and acetone, derived from the bark of Fraxinus chinensis, the bark of Fraxinus microphylla, and the leaves of Fraxinus himachicola.
Uses
Fraxetin is a coumarin compound with anti-oxidant and anti-inflammatory activity. Also acts as a protective agent against hyperuricemia and renal dysfunction.
Definition
ChEBI: Fraxetin is a hydroxycoumarin that is 6-methoxycoumarin in which the hydrogens at positions 7 and 8 have been replaced by hydroxy groups. It has a role as an Arabidopsis thaliana metabolite, an antimicrobial agent, an apoptosis inhibitor, an apoptosis inducer, an antioxidant, an anti-inflammatory agent, a hepatoprotective agent, an antibacterial agent and a hypoglycemic agent. It is a hydroxycoumarin and an aromatic ether.
in vivo
Fraxetin (20-50 mg/kg, gavage, once daily, 24 weeks) has a hepatoprotective effect in mice and also has antioxidant and anti-inflammatory activities[3].
| Animal Model: | Ethanol-induced liver fibrosis model in rats [3] |
| Dosage: | 20, 50 mg/kg; daily; 24 weeks |
| Administration: | i.g. |
| Result: | Reduced serum ALT and AST, weakened tissue pathological changes, upregulated heme oxygenase-1 (HO-1) protein, reduced lipid peroxidation, enhanced liver antioxidant capacity, inhibited CYP2E1 activity, and reduced inflammatory mediators such as TNF-α and IL-1β. |
7,8-DIHYDROXY-6-METHOXYCOUMARIN Preparation Products And Raw materials
Raw materials
Preparation Products
7,8-DIHYDROXY-6-METHOXYCOUMARIN Suppliers
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View Lastest Price from 7,8-DIHYDROXY-6-METHOXYCOUMARIN manufacturers
- Product
- Fraxetin 574-84-5
- Price
- US $0.00/mg
- Min. Order
- 5mg
- Purity
- ≥98%(HPLC)
- Supply Ability
- 10 g
- Release date
- 2019-09-17
- Product
- Fraxetin 574-84-5
- Price
- US $0.00/mg
- Min. Order
- 5mg
- Purity
- Analytical Standard
- Supply Ability
- 10 g
- Release date
- 2019-09-17
- Product
- 7,8-DIHYDROXY-6-METHOXYCOUMARIN 574-84-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-29