(5-Fluoro-pyridin-2-yl)-Methyl-aMine
- Product Name
- (5-Fluoro-pyridin-2-yl)-Methyl-aMine
- CAS No.
- 868636-72-0
- Chemical Name
- (5-Fluoro-pyridin-2-yl)-Methyl-aMine
- Synonyms
- 5-fluoro-N-methyl-2-Pyridinamine;3-Fluoro-6-(methylamino)pyridine;5-fluoro-N-Methylpyridin-2-aMine;2-Pyridinamine, 5-fluoro-N-methyl-;(5-Fluoro-pyridin-2-yl)-Methyl-aMine
- CBNumber
- CB72575303
- Molecular Formula
- C6H7FN2
- Formula Weight
- 126.13
- MOL File
- 868636-72-0.mol
(5-Fluoro-pyridin-2-yl)-Methyl-aMine Property
- Boiling point:
- 184.8±25.0 °C(Predicted)
- Density
- 1.186±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 5.14±0.10(Predicted)
- Appearance
- Colorless to light yellow Liquid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P363Wash contaminated clothing before reuse.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- F600103
- Product name
- 5-Fluoro-N-methylpyridin-2-amine
- Packaging
- 100mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- PC408017
- Product name
- 3-Fluoro-6-(methylamino)pyridine
- Packaging
- 1g
- Price
- $350
- Updated
- 2021/12/16
- Product number
- 34318
- Product name
- 5-fluoro-N-methylpyridin-2-amine
- Purity
- 97%
- Packaging
- 1g
- Price
- $750
- Updated
- 2021/12/16
- Product number
- Z2980
- Product name
- 5-Fluoro-N-methylpyridin-2-amine
- Packaging
- 10g
- Price
- $860
- Updated
- 2021/12/16
- Product number
- 3H32-3-6Y
- Product name
- 5-Fluoro-N-methylpyridin-2-amine
- Packaging
- 1g
- Price
- $560
- Updated
- 2021/12/16
(5-Fluoro-pyridin-2-yl)-Methyl-aMine Chemical Properties,Usage,Production
Synthesis
74-88-4
868636-72-0
Step 1. Synthesis of 5-fluoro-N-methylpyridin-2-amine: A suspension of sodium hydride (60% dispersed in mineral oil, 117.8 mg, 4.91 mmol) was made in dry tetrahydrofuran (25 mL). Subsequently, a solution of 5-fluoropyridin-2-amine (500 mg, 4.46 mmol) in tetrahydrofuran (25 mL) was added dropwise to this suspension. The reaction mixture was stirred at room temperature and maintained at 40 °C for 30 min. After that, the reaction system was cooled to -40 °C and methyl iodide (696.9 mg, 4.91 mmol) was slowly added. After addition, the reaction mixture was returned to room temperature and stirred overnight. Upon completion of the reaction, the reaction was quenched by the addition of water and the mixture was extracted with ethyl acetate. The organic phases were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The resulting crude product was purified by fast column chromatography on silica gel with hexane/ethyl acetate (4:1, v/v) as eluent to give 129 mg of the title compound in 23% yield. The product was characterized by 1H-NMR (CDCl3): δ 7.97 (1H, d, J = 2.6 Hz), 7.28-7.17 (1H, m), 6.34 (1H, dd, J = 3.5, 9.1 Hz), 2.90 (3H, d, J = 5.1 Hz).
References
[1] Patent: WO2005/105732, 2005, A1. Location in patent: Page/Page column 57-58
(5-Fluoro-pyridin-2-yl)-Methyl-aMine Preparation Products And Raw materials
Raw materials
Preparation Products
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