ChemicalBook > CAS DataBase List > cis-5-Oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylic acid tert-butyl ester

cis-5-Oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylic acid tert-butyl ester

Product Name
cis-5-Oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylic acid tert-butyl ester
CAS No.
146231-54-1
Chemical Name
cis-5-Oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylic acid tert-butyl ester
Synonyms
tert-butyl (3aR,6aS)-5-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate;cis-tert-Butyl 5-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate;2-Boc-5-oxo-hexahydrocyclopenta[c]pyrrole;cis-2-Boc-5-oxohexahydrocyclopenta[c]pyrrole;(3aR,6aS)-2-Boc-5-oxohexahydrocyclopenta[c]pyrrole;tert-Butyl 5-oxo-octahydrocyclopenta-[c]pyrrole-2-carboxylate;tert-butyl cis-5-oxo-octahydrocyclopenta[c]pyrrole-2-carboxylate;cis-5-Oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylic acid tert-butyl ester;(3aR,6aS)-tert-Butyl 5-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate 95+%;tert-butyl cis-5-oxo-1,3,3a,4,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxylate
CBNumber
CB72597510
Molecular Formula
C12H19NO3
Formula Weight
225.28
MOL File
146231-54-1.mol
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cis-5-Oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylic acid tert-butyl ester Property

Melting point:
70-71 °C
Boiling point:
325.8±35.0 °C(Predicted)
Density 
1.139±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
-0.82±0.20(Predicted)
form 
solid
color 
White to yellow
InChI
InChI=1/C12H19NO3/c1-12(2,3)16-11(15)13-6-8-4-10(14)5-9(8)7-13/h8-9H,4-7H2,1-3H3/t8-,9+
InChIKey
GGNDIMLSSMWKDR-DTORHVGONA-N
SMILES
C(N1C[C@]2([H])CC(C[C@]2([H])C1)=O)(=O)OC(C)(C)C |&1:3,8,r|
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-W005946
Product name
cis-tert-Butyl5-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate
Purity
99.48%
Packaging
1g
Price
$40
Updated
2021/12/16
Apolloscientific
Product number
OR302643
Product name
(3aR,6aS)-tert-Butyl5-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate
Purity
95+%
Packaging
1g
Price
$103
Updated
2021/12/16
SynQuest Laboratories
Product number
4H51-1-4G
Product name
(3aR,6aS)-tert-Butyl 5-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate
Packaging
1g
Price
$114
Updated
2021/12/16
ChemScene
Product number
CS-W005946
Product name
cis-tert-Butyl5-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate
Purity
99.48%
Packaging
5g
Price
$126
Updated
2021/12/16
ChemScene
Product number
CS-W005946
Product name
cis-tert-Butyl5-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate
Purity
99.48%
Packaging
10g
Price
$240
Updated
2021/12/16
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cis-5-Oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylic acid tert-butyl ester Chemical Properties,Usage,Production

Synthesis

24424-99-5

96896-09-2

146231-54-1

Cis-hexahydrocyclopentadieno[c]pyrrol-5(1H)-one (2.0 g, 16 mmol) was used as starting material and dissolved in dichloromethane (50 mL). Subsequently, di-tert-butyl dicarbonate (5.2 g, 24 mmol), triethylamine (3.2 g, 32 mmol) and 4-dimethylaminopyridine (195 mg, 1.6 mmol) were added to the solution. The reaction mixture was stirred at room temperature for 16 hours. Upon completion of the reaction, it was quenched by adding water (100 mL) and the aqueous and organic phases were separated. The organic phase was dried with anhydrous sodium sulfate, filtered and concentrated to give the crude product. The crude product was purified by silica gel column chromatography (eluent ratio of petroleum ether:ethyl acetate=10:1) to finally obtain tert-butyl cis-5-oxooctahydrocyclopenta[c]pyrrole-2(1H)-carboxylate (3.4 g, 94.4% yield).

References

[1] Patent: US2017/112833, 2017, A1. Location in patent: Paragraph 0550-0551

cis-5-Oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylic acid tert-butyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from cis-5-Oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylic acid tert-butyl ester manufacturers

Career Henan Chemical Co
Product
cis-5-Oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylic acid tert-butyl ester 146231-54-1
Price
US $3.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2019-08-07

146231-54-1, cis-5-Oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylic acid tert-butyl esterRelated Search:

cis-2-Boc-hexahydropyrrolo[3,4-c]pyrrole DIETHYL CIS-1-BENZYL-3,4-PYRROLIDINEDICARBOXYLATE CIS-1-(TERT-BUTOXYCARBONYL)-4-FLUOROPYRROLIDINE-3-CARBOXYLIC ACID cis-ethyl (1R,2S)-2-cyanocyclopropane-1-carboxylate (3S,4S)-1-benzyl-N,4-dimethylpiperidin-3-amine hydrochloride cis-2-(tert-Butoxycarbonylamino)-1-cyclopentanecarboxylic acid Methyl cis-3-(Boc-amino)cyclobutanecarboxylate 1-Boc-octahydropyrrolo[2,... Methyl cis-4-Aminocyclohexanecarboxylate Hydrochloride 4α-Aminocyclohexan-1α-ol cis-3-AMino-cyclobutaneMethanol hydrochloride cis-4-Hydroxy-D-proline hydrochloride 2-BOC-HEXAHYDRO-PYRROLO[3,4-C]PYRROLE hexahydrocyclopenta[c]pyrrol-5(1H)-one N-BOC-HEXAHYDRO-5-OXOCYCLOPENTA[C]PYRROLE (3aR,6aS)-benzyl 5-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate (Meso-3aR,5r,6aS)-tert-butyl 5-hydroxyhexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate cis-2-Cbz-hexahydropyrrolo[3,4-c]pyrrole

  • cis-5-Oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylic acid tert-butyl ester
  • tert-Butyl 5-oxo-octahydrocyclopenta-[c]pyrrole-2-carboxylate
  • 2-Boc-5-oxo-hexahydrocyclopenta[c]pyrrole
  • (3aR,6aS)-5-Oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylic acid 1,1-dimethylethyl ester
  • (3aR,6aS)-5-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylic acid tert-butyl ester
  • Cyclopenta[c]pyrrole-2(1H)-carboxylic acid, hexahydro-5-oxo-, 1,1-dimethylethyl ester, (3aR,6aS)-rel-
  • cis-tert-Butyl 5-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate
  • tert-butyl cis-5-oxo-octahydrocyclopenta[c]pyrrole-2-carboxylate
  • (3aR,6aS)-2-Boc-5-oxohexahydrocyclopenta[c]pyrrole
  • (3aR,6aS)-tert-Butyl 5-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate 95+%
  • tert-butyl (3aR,6aS)-5-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate
  • tert-butyl cis-5-oxo-1,3,3a,4,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxylate
  • cis-2-Boc-5-oxohexahydrocyclopenta[c]pyrrole
  • rel-1,1-Dimethylethyl (3aR,6aS)-hexahydro-5-oxocyclopenta[c]pyrrole-2(1H)-carboxylate
  • 146231-54-1