N-BOC-HEXAHYDRO-5-OXOCYCLOPENTA[C]PYRROLE

Product Name: N-BOC-HEXAHYDRO-5-OXOCYCLOPENTA[C]PYRROLE
CAS No.: 148404-28-8
Chemical Name: N-BOC-HEXAHYDRO-5-OXOCYCLOPENTA[C]PYRROLE
Synonyms: JK841;N-BOC-HEXAHYDRO-5-OXOCYCLOPENTA[C]PYRROLE;N-boc-hexahydro-5-oxocyclopentyl [C] pyrrole;N-Boc-hexahydro-5-oxocyclopenta[C]pyrrole 95％ g 2;Hexahydrocyclopenta[c]pyrrol-5(1H)-one, N-BOC protected;ert-butyl 5-oxo-hexahydrocyclopenta[c]pyrrole-2(1H)-carboxylat;ert-butyl 5-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate;tert-butyl 5-oxo-hexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate;5-Oxohexahydrocyclopenta[c]pyrrole-2-carboxylic acid tert-butyl ester;5-Oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylic acid tert-butyl ester
CBNumber: CB81511172
Molecular Formula: C12H19NO3
Formula Weight: 225.28
MOL File: 148404-28-8.mol

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N-BOC-HEXAHYDRO-5-OXOCYCLOPENTA[C]PYRROLE Property

Boiling point:: 325.8±35.0 °C(Predicted)
Density: 1.139
storage temp.: 2-8°C
pka: -0.82±0.20(Predicted)
form: powder
color: White
InChI: InChI=1S/C12H19NO3/c1-12(2,3)16-11(15)13-6-8-4-10(14)5-9(8)7-13/h8-9H,4-7H2,1-3H3
InChIKey: GGNDIMLSSMWKDR-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CC2CC(=O)CC2C1

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FB142239
Product name: tert-Butyl 5-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate
Packaging: 250mg
Price: $100
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB142239
Product name: tert-Butyl 5-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate
Packaging: 500mg
Price: $150
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB142239
Product name: tert-Butyl 5-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate
Packaging: 1g
Price: $200
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB142239
Product name: tert-Butyl 5-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate
Packaging: 2g
Price: $250
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0389021
Product name: (3AR,6AS)-5-OXO-HEXAHYDRO-CYCLOPENTA[C]PYRROLE-2-CARBOXYLIC ACID TERT-BUTYL ESTER
Purity: 95.00%
Packaging: 5MG
Price: $497.76
Updated: 2021/12/16

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N-BOC-HEXAHYDRO-5-OXOCYCLOPENTA[C]PYRROLE Chemical Properties,Usage,Production

Synthesis

147528-20-9

148404-28-8

General procedure for the synthesis of N-BOC-hexahydro-5-oxocyclopenta[C]pyrrole from tert-butyl 2-propenyl-2-propargylcarbamate: Compound 2B (39 g, 202.2 mmol) was dissolved in ethylene glycol dimethyl ether (275 mL), followed by the addition of octacyclohexane (83 g, 242.7 mmol) and water (82.4 mL). The reaction mixture was stirred for 30 minutes, then warmed to 84 °C and stirred continuously at this temperature for 16 hours. Upon completion of the reaction, the reaction solution was concentrated and saturated saline (500 mL), ethyl acetate (250 mL) and 1 mol/L hydrochloric acid (240 mL) were added to dissolve the residual solids. The aqueous phase was separated and extracted with ethyl acetate (250 mL x 3). All organic phases were combined, washed with saturated saline (250 mL x 2), and then dried over anhydrous sodium sulfate. After filtration, the organic phase was concentrated under reduced pressure and finally purified by silica gel column chromatography with an eluent ratio of petroleum ether/ethyl acetate (v/v) = 3:1 to 2:1 to obtain the target product 2C (27.6 g, 61.3% yield) as a light yellow solid.

References

[1] Patent: TW2017/8224, 2017, A. Location in patent: Page/Page column 33; 34
[2] Tetrahedron, 1993, vol. 49, # 23, p. 5047 - 5054
[3] Tetrahedron Letters, 1993, vol. 34, # 13, p. 2087 - 2090

N-BOC-HEXAHYDRO-5-OXOCYCLOPENTA[C]PYRROLE Preparation Products And Raw materials

Raw materials

Preparation Products

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N-BOC-HEXAHYDRO-5-OXOCYCLOPENTA[C]PYRROLE Suppliers

China 139 India 2 United Kingdom 2 United States 5 Global 148

Shanghai Tube Pharmaceutical Co., Ltd.

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Shangchem Co., Ltd.

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Nanjing Chemlin Chemical Co., Ltd

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Shanghai Hanhong Scientific Co.,Ltd.

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skychemical Co.Ltd

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View Lastest Price from N-BOC-HEXAHYDRO-5-OXOCYCLOPENTA[C]PYRROLE manufacturers

Career Henan Chemical Co

Product: N-BOC-HEXAHYDRO-5-OXOCYCLOPENTA[C]PYRROLE 148404-28-8
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 10000KGS
Release date: 2020-01-09

148404-28-8, N-BOC-HEXAHYDRO-5-OXOCYCLOPENTA[C]PYRROLERelated Search:

cis-2-Boc-octahydro-pyrrolo[3,4-d]azepine hydrochloride MK-8617 N,N'-[1,2-Ethanediylbis(oxy-2,1-phenylene)]bis[N-(carboxymethyl)glycine 1,1'-bis[2-(octyloxy)ethyl] ester N-BOC-cis-4-fluoro-L-proline MG-132 SRT1720 N-(8-Benzyl-8-azabicyclo[3.2.1]oct-3-yl-exo)-2-methylpropanamide N-Boc-3-piperidineacetic acid N-(Methoxymethyl)-N-(trimethylsilylmethyl)benzylamine N-Boc-exo-3-aminotropane N-Boc-endo-3-aminotropane N-(3-HYDROXYPROPYL)ETHYLENEDIAMINE 2-BOC-HEXAHYDRO-PYRROLO[3,4-C]PYRROLE hexahydrocyclopenta[c]pyrrol-5(1H)-one (3aR,6aS)-benzyl 5-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate cis-5-Oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylic acid tert-butyl ester (Meso-3aR,5r,6aS)-tert-butyl 5-hydroxyhexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate 2-methyl-octahydrocyclopenta[c]pyrrol-5-one

Cyclopenta[c]pyrrole-2(1H)-carboxylic acid, hexahydro-5-oxo-, 1,1-diMethylethyl ester

tert-butyl 5-oxo-hexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate

JK841

ert-butyl 5-oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate

N-Boc-hexahydro-5-oxocyclopenta[C]pyrrole 95％ g 2

cis-5-Oxo-hexahydro-cyclopenta[c]pyrrole-2-carboxylic acid tert-butyl ester

tert-Butyl 5-oxo-1,3,3a,4,6,6a-hexahydrocyclopenta[c]pyrrole-2-carboxylate

Hexahydrocyclopenta[c]pyrrol-5(1H)-one, N-BOC protected

N-BOC-HEXAHYDRO-5-OXOCYCLOPENTA[C]PYRROLE

ert-butyl 5-oxo-hexahydrocyclopenta[c]pyrrole-2(1H)-carboxylat

5-Oxohexahydrocyclopenta[c]pyrrole-2-carboxylic acid tert-butyl ester

N-boc-hexahydro-5-oxocyclopentyl [C] pyrrole

5-Oxohexahydrocyclopenta[c]pyrrole-2(1H)-carboxylic acid tert-butyl ester

Cyclopenta[c]pyrole-2(1H)-carboxylic acid, hexahydro-5-oxo-,1,1-dimethylethyl ester

148404-28-8