MG149

Product Name: MG149
CAS No.: 1243583-85-8
Chemical Name: MG149
Synonyms: MG 149;CS-1878;MG 149;MG-149;CHEMBL1215739;MG149 USP/EP/BP;Tip60 HAT inhibitor;MG 149, 10 mM in DMSO;CHEMBL1215739; MG 149; MG-149;2-(4-heptylphenethyl)-6-hydroxybenzoic acid;2-[2-(4-heptylphenyl)ethyl]-6-hydroxy-benzoic acid
CBNumber: CB72598759
Molecular Formula: C22H28O3
Formula Weight: 340.46
MOL File: 1243583-85-8.mol

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MG149 Property

Boiling point:: 477.8±33.0 °C(Predicted)
Density: 1.100±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≥114 mg/mL in DMSO; ≥30.5 mg/mL in EtOH; insoluble in H2O
form: Powder
pka: 3.06±0.30(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 22135
Product name: MG149
Purity: ≥98%
Packaging: 1mg
Price: $43
Updated: 2024/03/01

Cayman Chemical

Product number: 22135
Product name: MG149
Purity: ≥98%
Packaging: 5mg
Price: $167
Updated: 2024/03/01

Cayman Chemical

Product number: 22135
Product name: MG149
Purity: ≥98%
Packaging: 10mg
Price: $290
Updated: 2024/03/01

Cayman Chemical

Product number: 22135
Product name: MG149
Purity: ≥98%
Packaging: 25mg
Price: $570
Updated: 2024/03/01

ApexBio Technology

Product number: B3276
Product name: MG149
Packaging: 100mg
Price: $679
Updated: 2021/12/16

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MG149 Chemical Properties,Usage,Production

Biological Activity

mg 149 is an inhibitor of histone acetyltransferases (hat) with ic50 values of 74μm and 47μm for tip60 and mof, respectively [1].mg 149 is an anacardic acid derivative. it shows selective inhibition towards the myst type of hats: tip60 and mof with ic50 values of 74μm and 47μm, respectively. the docking study shows that the inhibition of tip60 by mg 149 is competitive with respect to ac-coa in the ac-coa binding pocket of tip60. mg 149 also inhibits the activity of hat in nuclear extracts from hela cells using biotinylated histone h3 or histone h4 peptides as substrates. it is found to be more potent for histone h3 compared to histone h4. additionally, dna microarrays demonstrate that mg149 inhibits p53 and nf-kb pathways as well as a very limited number of other pathways [1, 2].

References

[1] ghizzoni m, wu j, gao t, haisma hj, dekker fj, george zheng y. 6-alkylsalicylates are selective tip60 inhibitors and target the acetyl-coa binding site. eur j med chem. 2012 jan;47(1):337-44.
[2] dekker fj, van den bosch t, martin ni. small molecule inhibitors of histone acetyltransferases and deacetylases are potential drugs for inflammatory diseases. drug discov today. 2014 may;19(5):654-60.

MG149 Preparation Products And Raw materials

Raw materials

Preparation Products

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MG149 Suppliers

China 81 United States 14 Global 95

VDM Biochemicals

Tel: 0330-2528181
Fax: 0330-2528171
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MedChemexpress LLC

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BOC Sciences

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Target molecule Corp.

Tel: 857-239-0968
Fax: 857-239-8801
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Country: United States
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Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
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Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

InvivoChem

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Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
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Cckinase, Inc.

Tel: +1 (732)236-3202
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Country: United States
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Aladdin Scientific

Tel: +1-+1(833)-552-7181
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TargetMol Chemicals Inc.

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ApexBio Technology

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Country: United States
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Cayman Chemical Company

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MedChemExpress

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Axon Medchem LLC

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View Lastest Price from MG149 manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: MG 149 1243583-85-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: MG 149 1243583-85-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-08

1243583-85-8, MG149Related Search:

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MG 149

2-[2-(4-heptylphenyl)ethyl]-6-hydroxy-benzoic acid

MG 149 Benzoic acid, 2-[2-(4-heptylphenyl)ethyl]-6-hydroxy-

MG149 2-[2-(4-heptylphenyl)ethyl]-6-hydroxy-Benzoic acid

2-(4-heptylphenethyl)-6-hydroxybenzoic acid

CS-1878

CHEMBL1215739

CHEMBL1215739; MG 149; MG-149

MG 149;MG-149

Tip60 HAT inhibitor

Benzoic acid, 2-[2-(4-heptylphenyl)ethyl]-6-hydroxy-

MG149 USP/EP/BP

HAT,Inhibitor,MG 149,Epigenetic Reader Domain,Apoptosis,HATs,inhibit,Histone Acetyltransferase,MG-149

MG 149, 10 mM in DMSO

1243583-85-8

Inhibitors