3-(BROMOMETHYL)BENZALDEHYDE
Uses- Product Name
- 3-(BROMOMETHYL)BENZALDEHYDE
- CAS No.
- 82072-23-9
- Chemical Name
- 3-(BROMOMETHYL)BENZALDEHYDE
- Synonyms
- 3-Formylbenzyl bromide;3-(BroMoMthyl)Benzaldehyde;3-(BROMOMETHYL)BENZALDEHYDE;Benzaldehyde, 3-(bromomethyl)-;3-(Bromomethyl)benzaldehyde97%;3-(Bromomethyl)benzaldehyde 97%
- CBNumber
- CB7262458
- Molecular Formula
- C8H7BrO
- Formula Weight
- 199.04
- MOL File
- 82072-23-9.mol
3-(BROMOMETHYL)BENZALDEHYDE Property
- Melting point:
- 49 °C
- Boiling point:
- 269.7±23.0 °C(Predicted)
- Density
- 1.524±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- solid
- color
- Pale yellow
- InChI
- InChI=1S/C8H7BrO/c9-5-7-2-1-3-8(4-7)6-10/h1-4,6H,5H2
- InChIKey
- OEPGAYXSRGROSQ-UHFFFAOYSA-N
- SMILES
- C(=O)C1=CC=CC(CBr)=C1
Safety
- Hazard Codes
- C
- Risk Statements
- 20/22-34
- Safety Statements
- 22-26-36/37/39-45
- Hazard Note
- Corrosive
- HS Code
- 2913000090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B678110
- Product name
- 3-(Bromomethyl)benzaldehyde
- Packaging
- 500mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- W8602
- Product name
- 3-(Bromomethyl)benzaldehyde
- Packaging
- 1g
- Price
- $123
- Updated
- 2021/12/16
- Product number
- FB154828
- Product name
- 3-(Bromomethyl)benzaldehyde
- Packaging
- 1g
- Price
- $150
- Updated
- 2021/12/16
- Product number
- 2715-9-X1
- Product name
- 3-(Bromomethyl)benzaldehyde
- Purity
- 97%
- Packaging
- 1g
- Price
- $176
- Updated
- 2021/12/16
- Product number
- FB154828
- Product name
- 3-(Bromomethyl)benzaldehyde
- Packaging
- 2g
- Price
- $230
- Updated
- 2021/12/16
3-(BROMOMETHYL)BENZALDEHYDE Chemical Properties,Usage,Production
Uses
3-(bromomethyl)benzaldehyde is an aldehyde derivative that can be used as a pharmaceutical intermediate.
Synthesis
28188-41-2
82072-23-9
The general procedure for the synthesis of 3-bromomethylbenzaldehyde from 3-cyanobenzyl bromide was as follows: first, intermediates 60 and 61 were synthesized via α-bromomethyl-toluenesulfonic acid.The specific operation consisted of slowly adding DIBAL-H (1.4 eq., 1.0 M in THF) to a solution of α-bromomethyl-toluenesulfonic acid (15.3 mmol) in toluene (30 mL) at 0 °C over a period of 30 min. The reaction mixture was continued to be stirred at 0 °C for 2 h and then poured into a mixture of 40 mL of dichloromethane and 100 mL of 10% HCl. After stirring for 1 h, the organic layer was separated and washed sequentially with water and brine. The aqueous layer was extracted twice with dichloromethane. The organic layers were combined, dried with Na2SO4, filtered and concentrated to give a semi-oil product, which was stored in a refrigerator to give the final 3-bromomethylbenzaldehyde as a white crystalline solid in quantitative yield. Subsequently, the resulting 3-bromomethylbenzaldehyde was reacted with acetone in ethanol according to the method described in Scheme 4 to give compound 61 as a light yellow crystalline solid. The product was analyzed by ESI MS, m/z: 420.9 [M + H]+; 1H NMR (400 MHz, CDCl3) δ: 7.71 (d, 2H, J = 16.0 Hz, H-1,5), 7.63-7.60 (m, 2H, aryl ring H), 7.54-7.50 (m, 2H, aryl ring H), 7.44-7.37 (m, 4H aryl ring H), 7.08 (d, 2H, J = 16.0 Hz, H-2,4), 4.50 (s, 4H, -CH2Br).
References
[1] Patent: US2012/46247, 2012, A1. Location in patent: Page/Page column 29
[2] Chemical Communications, 2014, vol. 50, # 56, p. 7424 - 7426
[3] Patent: WO2017/223086, 2017, A1. Location in patent: Page/Page column 84
[4] Tetrahedron, 1997, vol. 53, # 20, p. 6755 - 6790
[5] Patent: KR2018/56603, 2018, A. Location in patent: Paragraph 0363; 0365-0367
3-(BROMOMETHYL)BENZALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-(BROMOMETHYL)BENZALDEHYDE manufacturers
- Product
- 3-(Bromomethyl)benzaldehyde 82072-23-9
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 30tons/month
- Release date
- 2023-02-22
- Product
- 3-(BROMOMETHYL)BENZALDEHYDE 82072-23-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-28
- Product
- 3-(Bromomethyl)benzaldehyde 82072-23-9
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000kg
- Release date
- 2022-09-19