ChemicalBook > CAS DataBase List > Sinegin 3

Sinegin 3

Product Name: Sinegin 3
CAS No.: 35906-36-6
Chemical Name: Sinegin 3
Synonyms: Sinegin 3;Senegin III;Onjisaponin B;Onjisaponin B, >=98%;Onjisaponin B, 10 mM in DMSO;Olean-12-ene-23,28-dioic acid, 3-(β-D-glucopyranosyloxy)-2,27-dihydroxy-, 28-[O-6-deoxy-α-L-mannopyranosyl-(1→3)-O-[O-β-D-galactopyranosyl-(1→4)-O-β-D-xylopyranosyl-(1→4)-6-deoxy-α-L-mannopyranosyl-(1→2)]-6-deoxy-4-O-[(2E)-3-(4-methoxyphenyl)-1-oxo-2-propen-1-yl]-β-D-galactopyranosyl] ester, (2β,3β,...
CBNumber: CB72654127
Molecular Formula: C75H112O35
Formula Weight: 1573.67
MOL File: 35906-36-6.mol

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Sinegin 3 Property

Density: 1.54±0.1 g/cm3 (20 ºC 760 Torr)
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: Powder
pka: 4.14±0.70(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 30521
Product name: Onjisaponin B
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 30521
Product name: Onjisaponin B
Packaging: 10mg
Price: $363
Updated: 2024/03/01

Cayman Chemical

Product number: 30521
Product name: Onjisaponin B
Packaging: 5mg
Price: $193
Updated: 2024/03/01

Usbiological

Product number: 300718
Product name: Onjisaponin B
Packaging: 10mg
Price: $609
Updated: 2021/12/16

AK Scientific

Product number: 8193AH
Product name: OnjisaponinB
Packaging: 1mg
Price: $147
Updated: 2021/12/16

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Sinegin 3 Chemical Properties,Usage,Production

Chemical Properties

White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO. It is derived from Polygala tenuifolia Willd.

Uses

Onjisaponin B is an orally active natural product derived from Polygala tenuifolia. Onjisaponin B inhibits NF-κB p65. Onjisaponin B enhances autophagy and accelerates the degradation of mutant α-synuclein and huntingtin. Onjisaponin B reduces β-amyloid (Aβ) production. Onjisaponin B reduces radiation-induced cell apoptosis. Onjisaponin B has anti-oxidant and anti-inflammatory activities. Onjisaponin B can be used for neurological disease and radiation injury study, and its metabolite tenuifolin (TF) can enter the brain through the BBB[1][2][3][4].

Definition

ChEBI: Senegin III is a triterpenoid saponin isolated from Polygala senega var latifolia and has been shown to exhibit hypoglycemic activity. It has a role as a hypoglycemic agent and a plant metabolite. It is a cinnamate ester, a hydroxy monocarboxylic acid, a pentacyclic triterpenoid and a triterpenoid saponin. It is functionally related to a 4-methoxycinnamic acid. It derives from a hydride of an oleanane.

in vivo

Onjisaponin B (40 mg/kg; i.g.; once) cannot pass through the blood-brain barrier (BBB), but its metabolite tenuifolin (TF) can enter the brain through the BBB in mice^[2].
Onjisaponin B (20-40 mg/kg; i.g.; daily for 12 days) ameliorates dopaminergic (DA) neurodegeneration in a MPTP (HY-15608)-induced mouse model of Parkinson’s disease (PD) through anti-oxidant and anti-inflammatory activities mediated via the RhoA/ROCK2 signaling pathway^[2].
Onjisaponin B (10 mg/kg; p.o.; daily from 4 to 7 months of age) reduces β-amyloid production and improve cognitive impairments in transgenic mice^[3].
Onjisaponin B (2.5 mg/kg; p.o.; 4 days prior to irradiation) significantly reduces pathological changes and apoptosis and the nuclear translocation of p65 in the lung tissue of p65+/- mice following radiation^[4].

Animal Model:	C57BL/6J-Rela^em1Smoc mice (p65^+/- mice)^[4]
Dosage:	2.5 mg/kg
Administration:	Oral gavage (p.o.); 4 days prior to irradiation
Result:	Inhibited p65 and cas3 activation caused by p65, and significantly reduced pathological changes and apoptosis (caused by down-regulation of p65) and the nuclear translocation of p65 in the lung tissue of p65^+/- mice following radiation, but not in the thymus.

Animal Model:	C57BL/6J mice (male, 12 weeks old)^[2]
Dosage:	20, 40 mg/kg
Administration:	Intragastric gavage (i.g.); daily for 12 days
Result:	Had a neuroprotective effect on MPTP (HY-15608) induced Parkinson’s disease (PD) model mice. Recovered MPTP-induced motor impairment. Reduced the number of ionized calcium-binding adapter molecule 1 (IBA-1)-positive cells, suppressed microglial activation induced by MPTP. Inhibited the secretion of IL-1β, TNF-α, and IL-6. Decreased MDA levels but increased SOD levels, exerted antioxidant abilities in PD model mice.

Animal Model:	APPswe/PS1ΔE9 (APP/PS1) double-transgenic mice^[3]
Dosage:	10 mg/kg (200 μL (1 mg/mL) per 20 g body weight)
Administration:	Oral gavage (p.o.); daily from 4 to 7 months of age
Result:	No obvious toxic effects in mice. Did not alter mouse locomotor activity. Ameliorated cognitive impairments in amyloid precursor protein (APP)/ presenilin 1 (PS1) mice. Showed significantly lower numbers of 6E10-positive Aβ plaque and reduced plaque area.

References

[1] Wu AG, et al. Onjisaponin B derived from Radix Polygalae enhances autophagy and accelerates the degradation of mutant α-synuclein and huntingtin in PC-12 cells. Int J Mol Sci. 2013 Nov 15;14(11):22618-41. DOI:10.3390/ijms141122618
[2] Peng F, et al. The onjisaponin B metabolite tenuifolin ameliorates dopaminergic neurodegeneration in a mouse model of Parkinson's disease. Neuroreport. 2020 Apr 8;31(6):456-465. DOI:10.1097/WNR.0000000000001428
[3] Li X, et al. Traditional Chinese Nootropic Medicine Radix Polygalae and Its Active Constituent Onjisaponin B Reduce β-Amyloid Production and Improve Cognitive Impairments. PLoS One. 2016 Mar 8;11(3):e0151147. DOI:10.1371/journal.pone.0151147
[4] Wang TY, et al. Targeting p65 to inhibit Cas3 transcription by Onjisaponin B for radiation damage therapy in p65+/- mice. Phytomedicine. 2022 Sep;104:154317. DOI:10.1016/j.phymed.2022.154317

Sinegin 3 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Sinegin 3 manufacturers

Shaanxi Haibo Biotechnology Co., Ltd

Product: Sinegin 3 35906-36-6
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000ton
Release date: 2023-08-22

Shanghai Standard Technology Co., Ltd.

Product: Onjisaponin B 35906-36-6
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2020-03-06

Career Henan Chemical Co

Product: onjisaponin B 35906-36-6
Price: US $2.00/KG
Min. Order: 1KG
Purity: ≥98%
Supply Ability: 100kg
Release date: 2019-12-23

35906-36-6, Sinegin 3Related Search:

(3-sinapoyl)fructofuranosyl-(6-sinapoyl)glucopyranoside sibiricaxanthone B polygalic acid SENEGENIN Polygalacin D Tenuifoliside C polygalaxanthone III Tenuifoliside B Tenuifoliose A Arillanin A sibiricaxanthone A Onjisaponin A Tenuifoliside A senegin II Onjisaponin O Tenuifoliose J Polygalasaponin F 3-O-Feruloylsucrose

Onjisaponin B, >=98%

Onjisaponin B

Senegin III

Sinegin 3

Olean-12-ene-23,28-dioic acid, 3-(β-D-glucopyranosyloxy)-2,27-dihydroxy-, 28-[O-6-deoxy-α-L-mannopyranosyl-(1→3)-O-[O-β-D-galactopyranosyl-(1→4)-O-β-D-xylopyranosyl-(1→4)-6-deoxy-α-L-mannopyranosyl-(1→2)]-6-deoxy-4-O-[(2E)-3-(4-methoxyphenyl)-1-oxo-2-propen-1-yl]-β-D-galactopyranosyl] ester, (2β,3β,...

Onjisaponin B, 10 mM in DMSO

35906-36-6

C75H114O35

C75H112O35

Triterpenoids