ChemicalBook > CAS DataBase List > ETP46464

ETP46464

Product Name: ETP46464
CAS No.: 1345675-02-6
Chemical Name: ETP46464
Synonyms: ETP46464;ETP-46464 ，S8050;ETP46464 USP/EP/BP;ETP 46464; ETP46464;ETP-46464, 10 mM in DMSO;ATR Inhibitor III ETP-46464;2-methyl-2-[4-(2-oxo-9-quinolin-3-yl-4H-[1,3]oxazino[5,4-c]quinolin-1-yl)phenyl]propanenitrile;2-Methyl-2-(4-(2-oxo-9-(quinolin-3-yl)-2,4-dihydro-1H-[1,3]oxazino[5,4-c]quinolin-1-yl)phenyl);2-methyl-2-(4-(2-oxo-9-(quinolin-3-yl)-2H-[1,3]oxazino[5,4-c]quinolin-1(4H)-yl)phenyl)propanenitrile;Benzeneacetonitrile, α,α-dimethyl-4-[2-oxo-9-(3-quinolinyl)-2H-[1,3]oxazino[5,4-c]quinolin-1(4H)-yl]-
CBNumber: CB72662737
Molecular Formula: C30H22N4O2
Formula Weight: 470.52
MOL File: 1345675-02-6.mol

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ETP46464 Property

Boiling point:: 709.3±60.0 °C(Predicted)
Density: 1.310±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≥16.13 mg/mL in DMSO
form: solid
pka: 5.10±0.20(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1321
Product name: ETP-46464
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $128
Updated: 2025/07/31

Sigma-Aldrich

Product number: 5.00508
Product name: ATR Inhibitor III, ETP-46464 - CAS 1345675-02-7 - Calbiochem
Packaging: 10MG
Price: $265
Updated: 2024/03/01

Cayman Chemical

Product number: 19809
Product name: ETP-46464
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 19809
Product name: ETP-46464
Purity: ≥98%
Packaging: 5mg
Price: $134
Updated: 2024/03/01

Cayman Chemical

Product number: 19809
Product name: ETP-46464
Purity: ≥98%
Packaging: 10mg
Price: $249
Updated: 2024/03/01

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ETP46464 Chemical Properties,Usage,Production

Uses

ETP-46464 is used as an ATR inhibitor in the treatment of cancer-associated mutations.

Biological Activity

etp-46464 is a potent and selective inhibitor for atr (ic50 = 25 nm).atr (atm- and rad3-related) is a member of pikk (phosphatidylinositol 3-kinase-like kinases) that regulates the dna damage response pathways. it is a dna damage sensor that is activated upon genotoxic stresses (e.g. ionizing radiation, uv radiation and dna replication stalling) and phosphorylates its downstream substrates (e.g. p53, brca1 and chek1).etp-46464 abolished the g2/m checkpoint. it caused the presence of micronuclei or completely fragmented nuclei in cells under ionizing radiation. cells treated simultaneously with hydroxyurea and etp-46464 exhibited elevated atm and chk2 phosphorylation. in u2os cells, etp-46464 promoted the breakage of stalked replication forks. [1]

target

mTOR

IC 50

mTOR: 0.6 nM (IC₅₀); ATR: 14 nM (IC₅₀); ATM: 545 nM (IC₅₀); DNA-PK: 36 nM (IC₅₀); PI3Kα: 170 nM (IC₅₀)

References

1. toledo li, murga m, zur r et al. a cell-based screen identifies atr inhibitors with synthetic lethal properties for cancer-associated mutations. nat struct mol biol. 2011 jun;18(6):721-7.

ETP46464 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from ETP46464 manufacturers

Career Henan Chemical Co

Product: ETP46464 1345675-02-6
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-23

1345675-02-6, ETP46464Related Search:

KU-55933 (ATM Kinase Inhibitor) Selumetinib ABT-199 ABT 737 VE 822 PHA-680632

Benzeneacetonitrile, α,α-dimethyl-4-[2-oxo-9-(3-quinolinyl)-2H-[1,3]oxazino[5,4-c]quinolin-1(4H)-yl]-

alpha,alpha-Dimethyl-4-[2-oxo-9-(3-quinolinyl)-2H-[1,3]oxazino[5,4-c]quinolin-1(4H)-yl]-benzeneacetonitrile ETP46464

2-methyl-2-[4-(2-oxo-9-quinolin-3-yl-4H-[1,3]oxazino[5,4-c]quinolin-1-yl)phenyl]propanenitrile

ETP46464

alpha,alpha-Dimethyl-4-[2-oxo-9-(3-quinolinyl)-2H-[1,3]oxazino[5,4-c]quinolin-1(4H)-yl]-benzeneacetonitrile

ETP 46464; ETP46464

2-Methyl-2-(4-(2-oxo-9-(quinolin-3-yl)-2,4-dihydro-1H-[1,3]oxazino[5,4-c]quinolin-1-yl)phenyl)

ETP46464 USP/EP/BP

ATR Inhibitor III ETP-46464

2-methyl-2-(4-(2-oxo-9-(quinolin-3-yl)-2H-[1,3]oxazino[5,4-c]quinolin-1(4H)-yl)phenyl)propanenitrile

ETP-46464, 10 mM in DMSO

ETP-46464 ，S8050

1345675-02-6

Inhibitors

PI3K/Akt/mTOR

Akt

mTOR

PI3K