pilaralisib

Product Name: pilaralisib
CAS No.: 934526-89-3
Chemical Name: pilaralisib
Synonyms: CS-1670;pilaralisib;XL147(pilaralisib);Pilaralisib (XL-147);XL-147(Pilaralisib) (new);XL-147,Pilaralisib, SAR245408;PILARALISIB (XL147);SAR245408;XL 147;XL-147; SAR245408;XL147;XL 147;SAR-245408;SAR 245408;XL-147;SAR245408;XL147;XL 147;SAR-245408;SAR 245408; PILARALISIB;2-amino-N-[3-[[3-(2-chloro-5-methoxyanilino)quinoxalin-2-yl]sulfamoyl]phenyl]-2-methylpropanamide
CBNumber: CB72666700
Molecular Formula: C25H25ClN6O4S
Formula Weight: 541.02
MOL File: 934526-89-3.mol

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pilaralisib Property

Melting point:: 216-220oC
Density: 1.458±0.06 g/cm3(Predicted)
storage temp.: Refrigerator
solubility: DMSO (Slightly)
pka: 6.33±0.30(Predicted)
form: Solid
color: Light Yellow to Yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P314Get medical advice/attention if you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 18011
Product name: Pilaralisib
Purity: ≥98%
Packaging: 5mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 18011
Product name: Pilaralisib
Purity: ≥98%
Packaging: 10mg
Price: $153
Updated: 2024/03/01

Cayman Chemical

Product number: 18011
Product name: Pilaralisib
Purity: ≥98%
Packaging: 25mg
Price: $323
Updated: 2024/03/01

Cayman Chemical

Product number: 18011
Product name: Pilaralisib
Purity: ≥98%
Packaging: 50mg
Price: $581
Updated: 2023/06/20

TRC

Product number: P441390
Product name: Pilaralisib
Packaging: 10mg
Price: $120
Updated: 2021/12/16

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pilaralisib Chemical Properties,Usage,Production

Uses

Pilaralisib is a pan-PI3K inhibitor used in the treatment of patients with chronic lymphocytic leukemia or relapsed or refractory lymphoma.

Enzyme inhibitor

This selective, reversible, and ATP-competitive Class I PI3K inhibitor (FW = 541.02 g/mol; CAS 934526-89-3; Solubility: 100 mg/mL DMSO, when warmed; < 1 mg/mL H2O), also known as XL147, SAR245408, and N-(3- {[(3-{[2-chloro-5-(methoxy)phenyl]-amino}quinoxalin-2- yl)amino]sulfonyl}phenyl)-2-methylalaninamide, targets PI3Kα (IC50 = 39 nM, PI3Kδ (IC50 = 36 nM), and PI3Kγ (IC50 = 23 nM), but only weakly for PI3Kβ. Pilaralisib is active against human breast cancer cell lines with constitutive PI3K activation. PI3K inhibitors reduce AKT activity and relieves suppression of receptor tyrosine kinase expression and activity. XL147 shows dose-dependent inhibition of cell growth and levels of pAKT and pS6, signal transducers in the PI3K/AKT/TOR pathway. In HER2- overexpressing cells, pilaralisib inhibition of PI3K is attended by upregulation of expression and phosphorylation of multiple receptor tyrosine kinases, including HER3. Knockdown of FoxO1 and FoxO3a transcription factors suppressed the induction of HER3, InsR, IGF1R, and FGFR2 mRNAs upon inhibition of PI3K. In HER2(+) cells, knockdown of HER3 with siRNA or cotreatment with the HER2 inhibitors trastuzumab or lapatinib enhance XL147-induced cell death and inhibition of pAKT and pS6. When tested separately, trastuzumab and lapatinib synergized with XL147 for inhibition of pAKT and growth of established BT474 xenografts. Compared with XL147 alone, the combination exhibited a superior antitumor effect against trastuzumab-resistant tumor xenografts.

pilaralisib Preparation Products And Raw materials

Raw materials

Preparation Products

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pilaralisib Suppliers

China 76 India 1 United States 12 Global 89

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
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Target molecule Corp.

Tel: 857-239-0968
Fax: 857-239-8801
Email: service1@targetmol.com
Country: United States
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Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4660
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

BOC Sciences

Tel: +1-631-485-4226
Fax: 1-631-614-7828
Email: inquiry@bocsci.com
Country: United States
ProdList: 19553
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57505
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Cayman Chemical Company

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Country: United States
ProdList: 6213
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United States Biological

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ProdList: 6214
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Selleck Chemicals LLC

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Country: United States
ProdList: 824
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ChemieTek

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Country: United States
ProdList: 219
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View Lastest Price from pilaralisib manufacturers

Career Henan Chemical Co

Product: pilaralisib 934526-89-3
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-30

934526-89-3, pilaralisibRelated Search:

XL-652 XL-765,SAR245409 3-(3,4-Difluorobenzoyl)-1,2,3,6-tetrahydro-1,1-dimethylazepino[4,5-b]indole-5-carboxylic acid 1-methylethyl ester XL-019 N-Methoxyphthalimide 3'-Amino-4'-methoxyacetanilide p-Anisidine-3-sulfonic acid Cabozantinib BMS 833923 XL019 XL147

pilaralisib

Pilaralisib (XL-147)

2-Amino-N-[3-[N-[3-[(2-chloro-5-methoxyphenyl)amino]quinoxalin-2-yl]sulfamoyl]phenyl]-2-methylpropanamide

2-amino-N-[3-[[3-(2-chloro-5-methoxyanilino)quinoxalin-2-yl]sulfamoyl]phenyl]-2-methylpropanamide

XL147(pilaralisib)

XL-147,Pilaralisib, SAR245408

PILARALISIB (XL147);SAR245408;XL 147

XL-147;SAR245408;XL147;XL 147;SAR-245408;SAR 245408; PILARALISIB

XL-147; SAR245408;XL147;XL 147;SAR-245408;SAR 245408

CS-1670

Propanamide, 2-amino-N-[3-[[[3-[(2-chloro-5-methoxyphenyl)amino]-2-quinoxalinyl]amino]sulfonyl]phenyl]-2-methyl-

XL-147(Pilaralisib) (new)

934526-89-3

C25H25ClN6O4S

Inhibitors

API