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SC 144

Product Name
SC 144
CAS No.
895158-95-9
Chemical Name
SC 144
Synonyms
SC144;SC 144;SC-144;CS-805;SC 144; SC144;SC144;SC-144;SC 144;2-(7-fluoropyrrolo[1,2-a]quinoxalin-4-yl)hydrazide;N'-(7-Fluoropyrrolo[1,2-a]quinoxalin-4-yl)pyrazine-2-carbohydrazide;N'-(7-Fluoropyrrolo[1,2-a]quinoxalin-4-yl)-2-pyrazinecarbohydrazide;Pyrazinecarboxylic acid 2-(7-fluoropyrrolo[1,2-a]quinoxalin-4-yl)hydrazide
CBNumber
CB72666896
Molecular Formula
C16H11FN6O
Formula Weight
322.3
MOL File
895158-95-9.mol
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SC 144 Property

Density 
1.53±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
insoluble in EtOH; insoluble in H2O; ≥16.1 mg/mL in DMSO
form 
solid
pka
8.87±0.43(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
S199000
Product name
SC144
Packaging
100mg
Price
$1680
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
48649
Product name
SC144
Packaging
100mg
Price
$2525
Updated
2021/12/16
Biorbyt Ltd
Product number
orb146229
Product name
SC144
Purity
>98%
Packaging
1g
Price
$2691.1
Updated
2021/12/16
AK Scientific
Product number
SYN5458
Product name
SC144 hydrochloride
Packaging
10mg
Price
$160
Updated
2021/12/16
ChemScene
Product number
CS-4440
Product name
SC144
Purity
98.60%
Packaging
25mg
Price
$170
Updated
2021/12/16
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SC 144 Chemical Properties,Usage,Production

Uses

SC144 is an orally active small-molecule gp130 inhibitor.

Biological Activity

sc144 is an inhibitor of gp130 with ic50 values of 0.43 μmol/l and 0.88 μmol/l in nci/adr-res and hey cell lines, respectively [1].sc144 is a first-in-class small-molecule gp130 inhibitor with oral activity in ovarian cancer. it can substantially increase the phosphorylation of gp130 (s782) in both ovcar-8 and caov-3 cells in a time- and dose-dependent manner. the increase phosphorylation then suppresses stat3 signaling pathway since the constitutive stat3 activation is maintained by extracellular gp130 ligands, besides that, sc144 also causes substantial cell apoptosis in these cells. [1].apart from the effect on gp130, it has been reported that sc144 can directly bind and stabilize il-24 in cancer cells. additionally, sc144 has shown to have effects on cell cycle perturbation and apoptosis induction [2].sc144 may also have other cellular protein targets, resulting in multiple potential molecular mechanisms. sc144’s anticancer potency may be a sum of these effects [2].

References

[1] shili xu, fedora grande, antonio garofalo, et al. discovery of a novel orally active small-molecule gp130 inhibitor for the treatment of ovarian cancer. molecular cancer therapeutics. 2013 (12): 937-949.
[2] shili xu, takashi oshima, toshio imada, munetaka masuda, bikash debnath, fedora grande, antonio garofalo, nouri neamati. stabilization of mda-7/il-24 for colon cancer therapy. cancer letters. 2013 feb(335):421-430.

SC 144 Preparation Products And Raw materials

Raw materials

Preparation Products

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SC 144 Suppliers

China 72 India 1 United States 11 Global 84
Angel Pharmatech, Ltd.
Tel
17317130613
Fax
QQ3358272972
Email
3358272972@qq.com
Country
China
ProdList
3238
Advantage
58
Wuhan Shanhai Zhihe Biotechnology Co., Ltd.
Tel
17771424646
Email
shoubull@126.com
Country
China
ProdList
965
Advantage
58
Shanghai SuperLan Chemcial Technique Centre
Tel
021-2022843681 15618226720
Fax
+86-21-51601218
Email
chaolaichem@foxmail.com
Country
China
ProdList
7565
Advantage
58
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7553
Advantage
61
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
18521735133 18521732826;
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25015
Advantage
65
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4863
Advantage
58
TargetMol Chemicals Inc.
Tel
021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7934
Advantage
58
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3421
Advantage
58
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2989
Advantage
60
Hubei Jusheng Technology Co.,Ltd
Tel
027-59599241 18871490274
Fax
027-59599241
Email
1400878000@qq.com
Country
China
ProdList
9972
Advantage
58

895158-95-9, SC 144Related Search:

Pyrrole Trifluoroacetic acid 2,5-PYRIDINEDICARBOXYLIC ACID Octyl 4-methoxycinnamate Polyoxytrifluoro(trifluoromethyl)-1,2-ethanediyl, .alpha.-(1-carboxy-1,2,2,2-tetrafluoroethyl)-.omega.-tetrafluoro(trifluoromethyl)ethoxy- Bortezomib 2-METHOXYESTRADIOL PD 0325901 Belinostat (PXD101) Luminespib Crizotinib

  • 2-Pyrazinecarboxylic acid, 2-(7-fluoropyrrolo[1,2-a]quinoxalin-4-yl)hydrazide
  • 2-(7-fluoropyrrolo[1,2-a]quinoxalin-4-yl)hydrazide
  • SC 144
  • SC144
  • SC-144
  • Pyrazinecarboxylic acid 2-(7-fluoropyrrolo[1,2-a]quinoxalin-4-yl)hydrazide
  • SC 144; SC144
  • CS-805
  • SC144;SC-144;SC 144
  • N'-(7-Fluoropyrrolo[1,2-a]quinoxalin-4-yl)-2-pyrazinecarbohydrazide
  • N'-(7-Fluoropyrrolo[1,2-a]quinoxalin-4-yl)pyrazine-2-carbohydrazide
  • 895158-95-9
  • C16H11FN6O
  • Inhibitors