SC 144
- Product Name
- SC 144
- CAS No.
- 895158-95-9
- Chemical Name
- SC 144
- Synonyms
- SC144;SC 144;SC-144;CS-805;SC 144; SC144;SC144;SC-144;SC 144;SC144, 10 mM in DMSO;2-(7-fluoropyrrolo[1,2-a]quinoxalin-4-yl)hydrazide;N'-(7-Fluoropyrrolo[1,2-a]quinoxalin-4-yl)pyrazine-2-carbohydrazide;N'-(7-Fluoropyrrolo[1,2-a]quinoxalin-4-yl)-2-pyrazinecarbohydrazide
- CBNumber
- CB72666896
- Molecular Formula
- C16H11FN6O
- Formula Weight
- 322.3
- MOL File
- 895158-95-9.mol
SC 144 Property
- Density
- 1.53±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- insoluble in EtOH; insoluble in H2O; ≥16.1 mg/mL in DMSO
- form
- solid
- pka
- 8.87±0.43(Predicted)
- color
- Light yellow to yellow
- InChI
- InChI=1S/C16H11FN6O/c17-10-3-4-13-11(8-10)20-15(14-2-1-7-23(13)14)21-22-16(24)12-9-18-5-6-19-12/h1-9H,(H,20,21)(H,22,24)
- InChIKey
- UEADAWQSJOWXBK-UHFFFAOYSA-N
- SMILES
- C1(C(NNC2=NC3=C(N4C=CC=C42)C=CC(F)=C3)=O)=NC=CN=C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- S199000
- Product name
- SC144
- Packaging
- 100mg
- Price
- $1680
- Updated
- 2021/12/16
- Product number
- CS-4440
- Product name
- SC144
- Purity
- 98.60%
- Packaging
- 5mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- A2173
- Product name
- SC144
- Packaging
- 5mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- CS-4440
- Product name
- SC144
- Purity
- 98.60%
- Packaging
- 10mg
- Price
- $85
- Updated
- 2021/12/16
- Product number
- A2173
- Product name
- SC144
- Packaging
- 10mM(in 1mL DMSO)
- Price
- $88
- Updated
- 2021/12/16
SC 144 Chemical Properties,Usage,Production
Uses
SC144 is an orally active small-molecule gp130 inhibitor.
Biological Activity
sc144 is an inhibitor of gp130 with ic50 values of 0.43 μmol/l and 0.88 μmol/l in nci/adr-res and hey cell lines, respectively [1].sc144 is a first-in-class small-molecule gp130 inhibitor with oral activity in ovarian cancer. it can substantially increase the phosphorylation of gp130 (s782) in both ovcar-8 and caov-3 cells in a time- and dose-dependent manner. the increase phosphorylation then suppresses stat3 signaling pathway since the constitutive stat3 activation is maintained by extracellular gp130 ligands, besides that, sc144 also causes substantial cell apoptosis in these cells. [1].apart from the effect on gp130, it has been reported that sc144 can directly bind and stabilize il-24 in cancer cells. additionally, sc144 has shown to have effects on cell cycle perturbation and apoptosis induction [2].sc144 may also have other cellular protein targets, resulting in multiple potential molecular mechanisms. sc144’s anticancer potency may be a sum of these effects [2].
in vivo
SC144 (10 mg/kg; i.p.; daily for 58 days) suppresses tumor growth in human ovariancancer xenografts[1].
SC144 (100 mg/kg;p.o.; daily for 35 days) treatment shows the average tumor volume in mice 82% smaller than that in the control group[1].
| Animal Model: | Athymic mice (human ovarian cancer xenograft)[1] |
| Dosage: | 10 mg/kg |
| Administration: | I.p; daily for 58 days |
| Result: | Significantly inhibited tumor growth by about 73%. |
IC 50
IL6-beta
References
[1] shili xu, fedora grande, antonio garofalo, et al. discovery of a novel orally active small-molecule gp130 inhibitor for the treatment of ovarian cancer. molecular cancer therapeutics. 2013 (12): 937-949.
[2] shili xu, takashi oshima, toshio imada, munetaka masuda, bikash debnath, fedora grande, antonio garofalo, nouri neamati. stabilization of mda-7/il-24 for colon cancer therapy. cancer letters. 2013 feb(335):421-430.
SC 144 Preparation Products And Raw materials
Raw materials
Preparation Products
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