ChemicalBook > CAS DataBase List > SC 144

SC 144

Product Name
SC 144
CAS No.
895158-95-9
Chemical Name
SC 144
Synonyms
SC144;SC 144;SC-144;CS-805;SC 144; SC144;SC144;SC-144;SC 144;2-(7-fluoropyrrolo[1,2-a]quinoxalin-4-yl)hydrazide;N'-(7-Fluoropyrrolo[1,2-a]quinoxalin-4-yl)pyrazine-2-carbohydrazide;N'-(7-Fluoropyrrolo[1,2-a]quinoxalin-4-yl)-2-pyrazinecarbohydrazide;Pyrazinecarboxylic acid 2-(7-fluoropyrrolo[1,2-a]quinoxalin-4-yl)hydrazide
CBNumber
CB72666896
Molecular Formula
C16H11FN6O
Formula Weight
322.3
MOL File
895158-95-9.mol
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SC 144 Property

Density 
1.53±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
insoluble in EtOH; insoluble in H2O; ≥16.1 mg/mL in DMSO
form 
solid
pka
8.87±0.43(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
S199000
Product name
SC144
Packaging
100mg
Price
$1680
Updated
2021/12/16
ChemScene
Product number
CS-4440
Product name
SC144
Purity
98.60%
Packaging
5mg
Price
$50
Updated
2021/12/16
ApexBio Technology
Product number
A2173
Product name
SC144
Packaging
5mg
Price
$80
Updated
2021/12/16
ChemScene
Product number
CS-4440
Product name
SC144
Purity
98.60%
Packaging
10mg
Price
$85
Updated
2021/12/16
ApexBio Technology
Product number
A2173
Product name
SC144
Packaging
10mM(in 1mL DMSO)
Price
$88
Updated
2021/12/16
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SC 144 Chemical Properties,Usage,Production

Uses

SC144 is an orally active small-molecule gp130 inhibitor.

Biological Activity

sc144 is an inhibitor of gp130 with ic50 values of 0.43 μmol/l and 0.88 μmol/l in nci/adr-res and hey cell lines, respectively [1].sc144 is a first-in-class small-molecule gp130 inhibitor with oral activity in ovarian cancer. it can substantially increase the phosphorylation of gp130 (s782) in both ovcar-8 and caov-3 cells in a time- and dose-dependent manner. the increase phosphorylation then suppresses stat3 signaling pathway since the constitutive stat3 activation is maintained by extracellular gp130 ligands, besides that, sc144 also causes substantial cell apoptosis in these cells. [1].apart from the effect on gp130, it has been reported that sc144 can directly bind and stabilize il-24 in cancer cells. additionally, sc144 has shown to have effects on cell cycle perturbation and apoptosis induction [2].sc144 may also have other cellular protein targets, resulting in multiple potential molecular mechanisms. sc144’s anticancer potency may be a sum of these effects [2].

References

[1] shili xu, fedora grande, antonio garofalo, et al. discovery of a novel orally active small-molecule gp130 inhibitor for the treatment of ovarian cancer. molecular cancer therapeutics. 2013 (12): 937-949.
[2] shili xu, takashi oshima, toshio imada, munetaka masuda, bikash debnath, fedora grande, antonio garofalo, nouri neamati. stabilization of mda-7/il-24 for colon cancer therapy. cancer letters. 2013 feb(335):421-430.

SC 144 Preparation Products And Raw materials

Raw materials

Preparation Products

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SC 144 Suppliers

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895158-95-9, SC 144Related Search:

Pyrrole Trifluoroacetic acid 2,5-PYRIDINEDICARBOXYLIC ACID Octyl 4-methoxycinnamate Polyoxytrifluoro(trifluoromethyl)-1,2-ethanediyl, .alpha.-(1-carboxy-1,2,2,2-tetrafluoroethyl)-.omega.-tetrafluoro(trifluoromethyl)ethoxy- Bortezomib 2-METHOXYESTRADIOL PD 0325901 Belinostat (PXD101) Luminespib Crizotinib

  • 2-Pyrazinecarboxylic acid, 2-(7-fluoropyrrolo[1,2-a]quinoxalin-4-yl)hydrazide
  • 2-(7-fluoropyrrolo[1,2-a]quinoxalin-4-yl)hydrazide
  • SC 144
  • SC144
  • SC-144
  • Pyrazinecarboxylic acid 2-(7-fluoropyrrolo[1,2-a]quinoxalin-4-yl)hydrazide
  • SC 144; SC144
  • CS-805
  • SC144;SC-144;SC 144
  • N'-(7-Fluoropyrrolo[1,2-a]quinoxalin-4-yl)-2-pyrazinecarbohydrazide
  • N'-(7-Fluoropyrrolo[1,2-a]quinoxalin-4-yl)pyrazine-2-carbohydrazide
  • 895158-95-9
  • C16H11FN6O
  • Inhibitors