ChemicalBook > CAS DataBase List > HJC-0350
HJC-0350
- Product Name
- HJC-0350
- CAS No.
- 885434-70-8
- Chemical Name
- HJC-0350
- Synonyms
- CS-1879;HJC0350;HJC 0350;HJC-0350;HJC-0350;HJC0350;HJC 0350;1-(Mesitylsulfonyl)-2,4-diMethyl-1H-pyrrole;inhibit,HJC-0350,Inhibitor,HJC 0350,HJC0350;2,4-dimethyl-1-[(2,4,6-trimethylphenyl)sulfonyl]-1H-pyrrole;1H-Pyrrole, 2,4-dimethyl-1-[(2,4,6-trimethylphenyl)sulfonyl]-;2,4-Dimethyl-1-[(2,4,6-trimethylphenyl)sulfonyl]-1H-pyrrole HJC 0350
- CBNumber
- CB72668476
- Molecular Formula
- C15H19NO2S
- Formula Weight
- 277.38
- MOL File
- 885434-70-8.mol
More
Less
HJC-0350 Property
- Boiling point:
- 434.6±55.0 °C(Predicted)
- Density
- 1.13±0.1 g/cm3(Predicted)
- storage temp.
- room temp
- solubility
- DMSO: soluble5mg/mL, clear
- pka
- -6.94±0.70(Predicted)
- form
- powder
- color
- white to beige
More
Less
Safety
- WGK Germany
- 3
More
Less
N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- SML0820
- Product name
- HJC0350
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $109
- Updated
- 2022/05/15
Sigma-Aldrich
- Product number
- SML0820
- Product name
- HJC0350
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $425
- Updated
- 2022/05/15
Cayman Chemical
- Product number
- 22949
- Product name
- HJC0350
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 22949
- Product name
- HJC0350
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $93
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 22949
- Product name
- HJC0350
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $139
- Updated
- 2024/03/01
More
Less
HJC-0350 Chemical Properties,Usage,Production
Uses
HJC 0350 is a potent and selective inhibitor of EPAC2 and exhibits no inhibition of EPAC1.
Biological Activity
hjc 0350 is a potent and selective antagonist of epac2 with ic50 value of 0.3 μm [1].camp/camp regulated guanine nucleotide exchange factor (epac/camp-gef) is a guanine nucleotide exchange factor for the small gtpases rap1 and rap2 in response to intracellular camp. epac2 is mainly expressed in the central nervous system, pancreas and adrenal gland [1].hjc 0350 is a potent and selective epac2 antagonist. hjc 0350 competed with 8-nbd-camp in binding recombinant fusion protein epac2 with ic50 value of 0.3 μm and exhibited 133-fold more potent than camp, which competed with 8-nbd-camp in binding epac2 with ic50 value of 40 μm. in the presence of 25 μm camp, hjc 0350 (25 μm) inhibited epac2 gef activity but had no effect on epac1-mediated rap1-gdp exchange activity and camp-mediated pka activation, which suggested that hjc 0350 was epac2-specific antagonist. in hek293 cells expressing epac1- or epac2-based fluorescence resonance energy transfer (fret) sensor (epac2-fl or epac1-fl), hjc 0350 (10 μm) completely inhibited the 007-am (a membrane permeable epac selective camp analogue) induced decrease of fret in hek293/epac2-fl cells but had no effect on hek293/epac1-fl cells [1].
storage
Store at +4°C
References
[1]. chen h, tsalkova t, chepurny og, et al. identification and characterization of small molecules as potent and specific epac2 antagonists. j med chem, 2013, 56(3): 952-962.
HJC-0350 Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
HJC-0350 Suppliers
- Tel
- 0411-62910999 13889544652
- meilunui@163.com
- Country
- China
- ProdList
- 4727
- Advantage
- 58
- Tel
- Mobile:13665161512
- Fax
- +86-510-68873513
- Country
- China
- ProdList
- 1785
- Advantage
- 58
- Tel
- 021-50840321, 18601625411
- Fax
- 021-50840321
- thomasleehz@hotmail.com
- Country
- China
- ProdList
- 216
- Advantage
- 50
- Tel
- 021-58930698 15921516558
- Fax
- 86-021-58933679
- zhangyichao84@126.com
- Country
- China
- ProdList
- 914
- Advantage
- 55
- Tel
- 025-58849295 18951903616;
- Fax
- 025-68650336
- info@adooq.cn
- Country
- China
- ProdList
- 2990
- Advantage
- 60
- Tel
- 021-52996696，15000506266 15000506266
- Fax
- +86-21-52996696
- Country
- China
- ProdList
- 4512
- Advantage
- 55
- Tel
- 18657622632
- Fax
- -
- chemsharker@126.com
- Country
- China
- ProdList
- 371
- Advantage
- 55
- Tel
- Fax
- -
- eric_feng1954@126.com
- Country
- China
- ProdList
- 9248
- Advantage
- 55
- Tel
- +86-400-851-9921
- Fax
- +86-10-82826195
- sales@pharmacodia.com
- Country
- China
- ProdList
- 2317
- Advantage
- 55
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9806
- Advantage
- 58
- Tel
- 15076683720
- Fax
- 022-23754520
- klq@cw-bio.com
- Country
- China
- ProdList
- 4600
- Advantage
- 55
- Tel
- 021-2022843681 15618226720
- Fax
- +86-21-51601218
- lucy@atkchemical.com
- Country
- China
- ProdList
- 10285
- Advantage
- 58
- Tel
- 010-50973130 4009686088
- 3193328036@qq.com
- Country
- China
- ProdList
- 29785
- Advantage
- 68
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 0519-83246372 13585352506
- Fax
- 0519-83246372
- Country
- China
- ProdList
- 1844
- Advantage
- 58
- Tel
- 86-(0)29-85992781 17792393971
- info@lynnchem.com
- Country
- China
- ProdList
- 4587
- Advantage
- 58
- Tel
- 0512-56316828
- Fax
- 0512-56316826
- info@amateksci.com
- Country
- China
- ProdList
- 28806
- Advantage
- 58
- Tel
- 17317130613
- Fax
- QQ3358272972
- 3358272972@qq.com
- Country
- China
- ProdList
- 3251
- Advantage
- 58
- Tel
- 18019463053
- Fax
- 021-50966098
- sales@coolpharm.com
- Country
- China
- ProdList
- 13010
- Advantage
- 58
- Tel
- 020-31155029 18902330969
- Fax
- 020-31155029
- sales@tomums.cn
- Country
- China
- ProdList
- 4696
- Advantage
- 58
- Tel
- 15021845385
- 765325601@qq.com
- Country
- China
- ProdList
- 3609
- Advantage
- 58
- Tel
- 021-58447131 13564518121
- sales@dcchemicals.com
- Country
- China
- ProdList
- 9409
- Advantage
- 58
- Tel
- 0519-85788828 13775037613
- sales@chemrenpharm.com
- Country
- China
- ProdList
- 3600
- Advantage
- 58
- Tel
- 63313187 15358055255
- Fax
- QQ：63313187
- 63313187@qq.com
- Country
- China
- ProdList
- 1986
- Advantage
- 58
- Tel
- 021-38015121 15000105423
- wulan@absin.cn
- Country
- China
- ProdList
- 24731
- Advantage
- 58
- Tel
- 88888888888
- hongquchem@qq.com
- Country
- China
- ProdList
- 5132
- Advantage
- 58
- Tel
- 15869524721
- 3525679403@qq.com
- Country
- China
- ProdList
- 3991
- Advantage
- 58
- Tel
- 15527250409
- Fax
- QQ：2692360204
- wenhaotian12@163.com
- Country
- China
- ProdList
- 4495
- Advantage
- 58
- Tel
- 021-58432009 400-005-6266
- Fax
- 021-58436166
- marketing@energy-chemical.com
- Country
- China
- ProdList
- 44918
- Advantage
- 58
- Tel
- 13348960310 13348960310
- 3003867561@qq.com
- Country
- China
- ProdList
- 10002
- Advantage
- 58
- Tel
- 0519-85524369
- 3477467573@qq.com
- Country
- China
- ProdList
- 8617
- Advantage
- 58
- Tel
- 021-50967598 02150967598
- sales@abmole.cn
- Country
- China
- ProdList
- 4494
- Advantage
- 58
- Tel
- 0371-0371-55153829 18003835034
- Fax
- 18003835034（微信）
- 2853979819@qq.com
- Country
- China
- ProdList
- 9718
- Advantage
- 58
- Tel
- 18964309092 18964309092
- 2769493375@qq.com
- Country
- China
- ProdList
- 2634
- Advantage
- 58
- Tel
- 010-60605840 15801484223;
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 29774
- Advantage
- 58
- Tel
- 0513-68819626; 15152877458
- Fax
- 0513-68669626
- feiyubio@163.com
- Country
- China
- ProdList
- 4819
- Advantage
- 58
- Tel
- 18818260767
- Fax
- QQ 3610331285
- 2625930290@qq.com
- Country
- China
- ProdList
- 6973
- Advantage
- 58
- Tel
- 400-1647117 13681763483
- product02@bidepharm.com
- Country
- China
- ProdList
- 62075
- Advantage
- 58
- Tel
- 13549236410
- sales@invivochem.cn
- Country
- China
- ProdList
- 6753
- Advantage
- 58
- Tel
- 4008200310
- marketing@tsbiochem.com
- Country
- China
- ProdList
- 24647
- Advantage
- 58
- Tel
- 025-58851786 17714337195
- sales@tybiochem.com
- Country
- China
- ProdList
- 6813
- Advantage
- 58
- Tel
- 025-85560043 15850508050
- Fax
- 025-85563444
- cindy.huang@synzest.com
- Country
- China
- ProdList
- 12005
- Advantage
- 58
- Tel
- +86-18521732826
- market@aladdin-e.com
- Country
- China
- ProdList
- 48461
- Advantage
- 58
- Tel
- 18122215013
- 780229652@qq.com
- Country
- China
- ProdList
- 1163
- Advantage
- 58
- Tel
- +undefined-21-51877795
- Fax
- +86 21 5161 9052/ 5187 7796
- ivan@atkchemical.com
- Country
- China
- ProdList
- 32957
- Advantage
- 60
- Tel
- 13417589054
- trendseenbio@gmail.com
- Country
- China
- ProdList
- 11681
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@zzsrm.com
- Country
- CHINA
- ProdList
- 6650
- Advantage
- 58
- Tel
- --
- Fax
- --
- 1861586486@qq.com
- Country
- CHINA
- ProdList
- 6648
- Advantage
- 58
- Tel
- --
- Fax
- --
- shizezjp@163.com
- Country
- CHINA
- ProdList
- 6174
- Advantage
- 58
- Tel
- --
- Fax
- --
- 3245176082@qq.com
- Country
- CHINA
- ProdList
- 6134
- Advantage
- 58